Results 151 to 160 of about 3,137 (211)

The Amazonian “Bacuri” Seeds Butter (Platonia insignis Mart.) Improves Ex Vivo Aortic Vascular Dysfunction and In Vivo Oxidative Stress in L‐NAME‐Treated Rats

open access: yesPhytochemicals in Food and Medicine, Volume 1, Issue 4, December 2026.
Industrialised bacuri seed butter (Platonia insignis Mart.) exhibited antioxidant and vasorelaxant effects, improving vascular reactivity and oxidative stress biomarkers in hypertensive rats. These findings highlight MIB as a promising natural product for mitigating hypertension‐associated vascular dysfunction and oxidative stress.
Maisa Gomes da Silva   +16 more
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

open access: yesAnnals of Clinical and Translational Neurology, Volume 13, Issue 11, Page 2375-2381, November 2026.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem   +9 more
wiley   +1 more source

Clinical Features, Treatments, and Outcomes of an International Cohort of 96 Children with Takayasu Arteritis

open access: yesACR Open Rheumatology, Volume 8, Issue 11, November 2026.
Objective To characterize the clinical features, treatment, and outcomes of a large, international cohort of childhood‐onset Takayasu arteritis (cTAK). Methods Patients with a diagnosis of cTAK were identified in A Registry of Childhood Vasculitis and divided into subcohorts by era‐of diagnosis: pre‐biologic (PB; 1986–2006), early biologic (EB; 2007 ...
James Bistolarides   +29 more
wiley   +1 more source

Phase Separation of TRIM21 Modulates PTPN14 Stability to Drive Flow‐Dependent Endothelial Activation and Atherogenesis

open access: yesAdvanced Science, Volume 13, Issue 62, 9 November 2026.
Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He   +10 more
wiley   +1 more source

Leiomyosarcoma of the thoracic aorta

The Japanese Journal of Thoracic and Cardiovascular Surgery, 1999
This case involves a patient with aortic leiomyosarcoma. A patient clinically suspected of type IIIa dissecting aortic aneurysm underwent surgery. The descending thoracic aorta was found to be filled with a soft, yellow tumor and was replaced with a woven Dacron graft.
T, Yasuda   +3 more
openaire   +4 more sources

Surgery of the Thoracic Aorta

New England Journal of Medicine, 1997
The modern surgical treatment of disorders of the thoracic aorta began in the early 1950s when Gross, Swan, Lam, and DeBakey and their associates1–4 reported successful treatment of coarctation and aneurysms of the descending thoracic aorta using segmental resection and replacement with several types of grafts. In 1956, Cooley and DeBakey5 reported the
N T, Kouchoukos, D, Dougenis
openaire   +4 more sources

MRI of the Thoracic Aorta

Magnetic Resonance Imaging Clinics of North America, 2007
Diseases of the thoracic aorta cause significant morbidity and mortality and can result in potentially catastrophic consequences. Conventional digital subtraction angiography (DSA) has been the gold standard for imaging for many years; however, this is associated with adverse effects and provides only limited information about vessel morphology. DSA is
Christopher J, François, James C, Carr
openaire   +3 more sources

Thoracic aorta – dilated or not?

Scandinavian Cardiovascular Journal, 2006
Knowledge of normal aortic diameters is important in the assessment of aortic disease. The aim of this study was to determine normal thoracic aortic diameters.77 patients undergoing computed tomography of the thorax were studied. The diameter of the thoracic aorta was measured at three levels in the ascending aorta and at three levels in the descending
Matias, Hannuksela   +2 more
openaire   +2 more sources

Thoracic Aorta

2013
The thoracic aorta can be affected by both acute and chronic pathological conditions characterized by high mortality, whose early diagnosis plays a crucial role in their prognosis and therapy.
Galea N.   +4 more
openaire   +2 more sources

Coarctation of the Thoracic Aorta

The Annals of Thoracic Surgery, 1971
Abstract Operative resection is clearly the treatment of choice for coarctation of the thoracic aorta. The optimal time for elective repair appears to start at age 4 years. When coarctation must be dealt with in the first few months of life because of persisting congestive heart failure, there will be a significant mortality which is correlated with ...
G G, Lindesmith   +4 more
openaire   +2 more sources

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