Results 41 to 50 of about 745,128 (377)

Fibulin-4 is essential for maintaining arterial wall integrity in conduit but not muscular arteries [PDF]

, 2017
Homozygous or compound heterozygous mutations in fibulin-4 (FBLN4) lead to autosomal recessive cutis laxa type 1B (ARCL1B), a multisystem disorder characterized by significant cardiovascular abnormalities, including abnormal elastin assembly, arterial ...
Broekelmann, Thomas J, Chu, Mon-Li, Halabi, Carmen M, Lee, Vivian S, Lin, Michelle, Mecham, Robert P   +5 more
core   +3 more sources

Chronic L-Name-Treatment Produces Hypertension by Different Mechanisms in Peripheral Tissues and Brain: Role of Central eNOS

Pathophysiology, 2020
The goal of our study was to analyze the time course of the effect of NG-nitro-L-arginine methyl ester (L-NAME) on nitric oxide synthase (NOS) isoforms and nuclear factor–κB (NF-κB) protein expression, total NOS activity, and blood pressure (BP) in rats.
Olga Pechanova, Stanislava Vrankova, Martina Cebova   +2 more
doaj   +1 more source

Alginate hydrogel polymers enable efficient delivery of a vascular-targeted AAV vector into aortic tissue

Molecular Therapy: Methods & Clinical Development, 2021
Gene therapeutic approaches to aortic diseases require efficient vectors and delivery systems for transduction of endothelial cells (ECs) and smooth muscle cells (SMCs).
Anca Remes, Dima Ibrahim Basha, Thomas Puehler, Christopher Borowski, Susanne Hille, Laura Kummer, Andreas H. Wagner, Markus Hecker, Jasmin Soethoff, Georg Lutter, Derk Frank, Rawa Arif, Norbert Frey, Marcin Zaradzki, Oliver J. Müller   +14 more
doaj   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Wave propagation and reflection in the aorta and implications of the aortic Windkessel

Exploration of Medicine, 2021
Some have said that it is inappropriate and perhaps impossible to consider wave and Windkessel phenomena simultaneously. For 50 years, arterial hemodynamics has been dominated by the frequency-domain “impedance analysis” in which it was assumed that all ...
John V. Tyberg
doaj   +1 more source

Coarctation of the aorta

Radiopaedia.org, 2015
this “simple” condition still raises many questions. johan Meckel published 1768 “narrowing of the aortic conduit”. 1944 was the first successful surgical repair performed by clarence Crafoord and Robert Gross independently .
Tee Jin, Hani Salam
semanticscholar   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Upper Extremity Ischemia Complicating Ulcerative Plaque in Descending Aorta [PDF]

Journal of Cardio-Thoracic Medicine, 2017
A 54-year-old female patient was presented with upper extremity ischemia. Further investigation revealed ulcerated atherosclerosis plaque in aorta with intramural hematoma and clot formation.
Aliasghar Moeinipour, Mohamad Abbassi Teshnisi, Mohammad Sobhan Sheikh Andalibi, Ahmadreza Zarifian, Yasamin Moeinipour, Babak Manafi, Hamid Hoseinikh   +6 more
doaj   +1 more source

Abdominal Aortic Endothelial Dysfunction Occurs in Female Mice With Dextran Sodium Sulfate-Induced Chronic Colitis Independently of Reactive Oxygen Species Formation

Frontiers in Cardiovascular Medicine, 2022
Background and ObjectiveInflammatory bowel disease (IBD) produces significant local and systemic inflammation with increased reactive oxygen species (ROS) formation.
Hao Wu, Hao Wu, Tingzi Hu, Linfang Zhang, Xiujuan Xia, Xuanyou Liu, Qiang Zhu, Meifang Wang, Zhe Sun, Hong Hao, Yuqi Cui, Alan R. Parrish, De-Pei Li, Michael A. Hill, Canxia Xu, Zhenguo Liu   +15 more
doaj   +1 more source

Fetal heterotaxy with tricuspid atresia, pulmonary atresia, and isomerism of the right atrial appendages at 22 weeks. [PDF]

, 2013
We report the accurate prenatal diagnosis at 22 weeks gestation of right atrial isomerism in association with tricuspid atresia. Several distinctive sonographic features of isomerism of the right atrial appendages were present in this fetus: complex ...
Richardson, Randy R, Silverman, Norman H, Solomon, Julia E, Stock, John H   +3 more
core   +2 more sources