Results 91 to 100 of about 551,312 (317)

ZDHHC9‐Mediated Palmitoylation of ACSL4 Drives Ferroptosis in Diabetes Mellitus–Induced Erectile Dysfunction

Advanced Science, EarlyView.
ABSTRACT Diabetes mellitus‐induced erectile dysfunction (DMED) is a highly prevalent complication among diabetic patients; however, its underlying pathogenic mechanisms remain incompletely understood. Metabolic disorder is a hallmark of diabetes, yet its precise contribution to DMED progression is not well defined.
Wanyang Guo, Ming Xiao, Mengjun Huang, Dongzi Peng, Ruijiang Zeng, Ruilin Liu, Yuanqiao Zhao, Zhihan Ouyang, Yulong Hong, Zexian Ding, Zhuo Xing, Hao Su, Jinxiang Wang, Wenjun Mao, Xin Jin   +14 more
wiley   +1 more source

Impact of new technologies and experience on procedural aspects of surgical aortic valve replacement – a process analysis

Swiss Medical Weekly, 2017
BACKGROUND Surgical aortic valve replacement (SAVR) is the treatment of choice in severe symptomatic aortic valve disease. New techniques and prostheses have been recently developed to facilitate the procedure and reduce aortic cross-clamp ...
Bettina Langhammer, Maria Nucera, Lars Englberger, Eva Roost, David Reineke, Florian Schönhoff, Henriette Most, Bernhard Winkler, Fabian Gisler, Thierry Carrel, Christoph Huber   +10 more
doaj   +1 more source

Tropomyosin 1 Promotes Platelet Adhesion and Clot Contraction Separate from Its Roles in Developmental Hematopoiesis

Advanced Science, EarlyView.
ABSTRACT Genome‐wide association studies (GWAS) link the Tropomyosin 1 (Tpm1) locus to quantitative blood trait variation, but related mechanisms are unclear. Tpm1 encodes an actin‐binding protein that regulates actin filament diversity, cell adhesion, signaling, and actomyosin contractility.
Po‐Lun Kung, Victor Tsao, Alina D Peshkova, Oscar A. Marcos‐Contreras, Kim Ha, Brian M Dulmovits, Nkemdilim Okoli, Anvi Sinha, Gennadiy Fonar, Rong Qiu, Rolf D Bates, Janelle Yeboah, Carson Shalaby, Tyler Truex, Soomin Jeong, Edna C Hardeman, Peter W Gunning, Vladimir R Muzykantov, Jacob W Myerson, Christopher S Thom   +19 more
wiley   +1 more source

Successful Pulsed-Field Ablation of Superior Vena Cava Fibrillation Using a Circular Multielectrode Array Catheter

JACC: Case Reports
Introduction: Some reports have described superior vena cava isolation (SVCI) by the pentaspline pulsed-field ablation (PFA) catheter. However, this report presents a case series of superior vena cava (SVC) fibrillation successfully treated using a ...
Masatsugu Nozoe, MD, PhD, Hiroshi Mannoji, MD, PhD, Ryo Miyake, MD, Sayana Kuraoka, MD, Akihito Ishikita, MD, PhD, Nobuhiro Suematsu, MD, PhD, Toru Kubota, MD, PhD   +6 more
doaj   +1 more source

Neural Fields for Highly Accelerated 2D Cine Phase Contrast MRI

Advanced Science, EarlyView.
ABSTRACT 2D cine phase contrast (CPC) MRI provides quantitative information on blood velocity and flow within the human vasculature. However, data acquisition is time‐consuming, motivating the reconstruction of the velocity field from undersampled measurements to reduce scan times. In this work, neural fields are proposed as a continuous spatiotemporal
Pablo Arratia, Martin J. Graves, Mary McLean, Carolin Pirkl, Carola‐Bibiane Schönlieb, Timo Schirmer, Florian Wiesinger, Matthias J. Ehrhardt   +7 more
wiley   +1 more source

The hemostatic power of fat: An effective, inexpensive, and biocompatible method to achieve hemostasis in cardiac surgery

Türk Kardiyoloji Derneği Arşivi, 2018
Postoperative bleeding with its important socioeconomic cost is associated with an increased morbidity and mortality. It causes hemodynamic instability, increases blood loss, and multiplies the number of transfusions required.
María Elena Arnáiz García, Jose María González- Santos, Javier López- Rodríguez, Ana María Arnáiz- García, Javier Arnáiz   +4 more
doaj   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Acute type B aortic dissection in the absence of aortic dilatation

, 2012
BackgroundIncreasing aortic diameter is thought to be an important risk factor for acute type B aortic dissection (ABAD). However, some patients develop ABAD in the absence of aortic dilatation. In this report, we sought to characterize ABAD patients who
J. B. Froehlich, Iternational Registry of Acute Aortic Dissection investigators, Rampoldi, Vincenzo, B. E. Muhs, Jonker, Frederik H.W., Muhs, Bart E., Trimarchi, Santi, Eagle, Kim A., F. L. Moll, K. A. Eagle, G. R. Upchurch, H. J. Patel, V. Rampoldi, Patel, Himanshu J., Froehlich, James B., S. Trimarchi, F. H. W. Jonker, Upchurch, Gilbert R., Moll, Frans L.   +18 more
core   +1 more source

Midterm follow-up of composite graft replacement of the aortic root (30-year experience)—remarkably safe, effective, and durableCentral MessagePerspective

JTCVS Open
Objectives: Contemporary operative choices for aortic root disease include aortic root replacement (ARR) and a variety of valve-sparing and aortic root-repair procedures.
Syeda Manahil Haider Jeoffrey, MD, Mohammad A. Zafar, MBBS, Juan Velasco, MD, Ahad Khattak, MD, Hesham Ellauzi, MB BCh, BAO (hons), Afsheen Nasir, MD, Asanish Kalyanasundaram, MD, Bulat A. Ziganshin, MD, PhD, John A. Elefteriades, MD, PhD (Hon)   +8 more
doaj   +1 more source

Aortic Valve Sparing in Different Aortic Valve and Aortic Root Conditions

Journal of the American College of Cardiology, 2016
The development of aortic valve-sparing operations (reimplantation of the aortic valve and remodeling of the aortic root) expanded the surgical armamentarium for treating patients with aortic root dilation caused by a variety of disorders. Young adults with aortic root aneurysms associated with genetic syndromes are ideal candidates for reimplantation ...
openaire   +2 more sources