Results 111 to 120 of about 607,556 (305)

The ETTAA study protocol: a UK-wide observational study of 'Effective Treatments for Thoracic Aortic Aneurysm'. [PDF]

, 2015
Introduction Chronic thoracic aortic aneurysm (CTAA) affecting the arch or descending aorta is an indolent but life-threatening condition with a rising prevalence as the UK population ages.
Catarino, P., ETTAA Collaborators, Gray, J, Vallabhaneni, S, Vale, L., Vallabhaneni, Srinivasa, Cook, A., Moorjani, N, Moorjani, Narain, Vale, Luke, Sharples, L., Gray, Joanne, Cook, Andrew, Elefteriades, JA, Sastry, P., Sharples, Linda, Vallabhaneni, S. R., Sastry, P, Moorjani, N., Hughes, V., Elefteriades, John, Cook, A, Catarino, Pedro, Hughes, V, Elefteriades, J., Hayes, P, on behalf of the ETTAA collaborators, Thompson, M., Hayes, P., Gray, J., Vale, L, Large, Stephen, Catarino, P, Thompson, Matt, Sharples, L, Hughes, Victoria, Elefteriades, John A, Hayes, Paul, Thompson, M, Sastry, Priya, Large, Stephen R, Large, SR, Large, S. R.   +42 more
core   +1 more source

Endoluminal rescue of false lumen graft deployment in TEVAR for type B aortic dissection: a case report and literature review

Frontiers in Cardiovascular Medicine
BackgroundThoracic endovascular aortic repair (TEVAR) has increasingly become the preferred surgical intervention for Stanford type B aortic dissection (TBAD).
Hong Jiang Zhu, Feng Yan, Peng Peng Zhao
doaj   +1 more source

AI Designed Conformation Locking Peptides Target STING to Restore Diabetic Wound Healing

Advanced Science, EarlyView.
A generative AI pipeline identifies SCP‐1, a conformation‐locking peptide that stabilizes inactive STING. Incorporated into a dual‐responsive hydrogel for localized, MMP‐9‐triggered release, SCP‐1 suppresses inflammation, promotes reparative macrophage polarization, and accelerates diabetic wound healing.
Xinyu Li, Haojie Fu, Zhe Wang, Xuanzhou Chen, Ruhong Zhang, Xudong Wang, Louis D. Zhang, Xiang Li, Datao Li   +8 more
wiley   +1 more source

High-intensity interval exercise training before abdominal aortic aneurysm repair (HIT-AAA): protocol for a randomised controlled feasibility trial [PDF]

, 2014
Introduction: In patients with large abdominal aortic aneurysm (AAA), open surgical or endovascular aneurysm repair procedures are often used to minimise the risk of aneurysm-related rupture and death; however, aneurysm repair itself carries a high risk.
Kerr, K., Kerr, Karen, Weston, Matthew; id_orcid, Tew, G.A., Tew, Garry A, Tew, Garry, Danjoux, Gerard, Batterham, A.M., Batterham, Alan M, Alan M Batterham, Gray, Joanne, Martin, D., Danjoux, Gerard R., Nawaz, Shah, Matthew Weston, Yates, David, Weston, M., Elke Kothmann, Tew, G. A. (Garry), Gerard Danjoux, Gray, J., Weston, Matthew, Yates, D., Garry A Tew, Kothmann, Elke, Martin, Denis, Denis Martin, Martin, Denis; id_orcid, Nawaz, S., Batterham, Alan, Shah Nawaz, Kothmann, E., Joanne Gray, Danjoux, G., David Yates, Karen Kerr   +35 more
core   +1 more source

A Markov decision analysis model to aid the vascular surgeon in the management of a patient with an asymptomatic infra-renal abdominal aortic aneurysm [PDF]

, 2010
Introduction Despite increasing evidence regarding the safety and efficacy of endovascular (EVAR) and open abdominal aortic aneurysm repair, it is often unclear which technique is most appropriate for an individual patient.
Drury, Duncan
core   +2 more sources

USP5 Stabilizes TGFBR1 to Drive Vascular Smooth Muscle Cell Senescence and Atherosclerosis

Advanced Science, EarlyView.
This study reveals that USP5 drives vascular smooth muscle cell senescence and atherosclerosis by stabilizing TGFBR1, suppressing IDH2, and promoting glycolytic reprogramming, identifying the USP5‐TGFBR1‐IDH2 axis as a potential therapeutic target. ABSTRACT Vascular smooth muscle cell (VSMC) senescence contributes importantly to atherosclerotic plaque ...
Xinhai Cui, Yuanlong Hu, Lin Lin, Lei Zhang, Chao Li, Yunlun Li   +5 more
wiley   +1 more source

Stress Hyperglycemia Drives CD4+ T Cell PANoptosis and Postoperative Organ Injury via Monocyte‐Derived Succinate

Advanced Science, EarlyView.
High glucose is linked to reduced succinate dehydrogenase activity in CD14+ monocytes, accompanied by succinate accumulation and extracellular release. Extracellular succinate exacerbates mitochondrial ROS production and mtDNA release in CD4+ T cells. Cytosolic mtDNA then activates Z‐DNA binding protein 1 (ZBP1) and engages ZBP1‐associated inflammatory
Shuai Zhao, Xuemei Miao, Wei Luo, Tao Liu, Yang Wang, Jiaying Li, Di Fu, Weiyun Shen, Yan Luo, Kang Chen, Ruping Dai, Hui Li   +11 more
wiley   +1 more source

Outcome of acute type A aortic dissection: single-center experience from 1998 to 2007 [PDF]

, 2009
Introduction. Acute aortic dissection (AAD) is a serious disease of the aorta with high mortality and morbidity, which requires emergency surgical treatment in order to close the site of the dissection and direct blood flow into the true lumen.
Zizza A., Zaccaria S., GUIDO, Marcello, Pano M., Villani M., the Aortic Dissection Study Group   +5 more
core  

P503: Historical prospective study of the link between JAK2-V617F and thoracic aortic aneurysm

Genetics in Medicine Open, 2023
Deqiong Ma, Andreea Popa, Daniel Dykas, Bulat Ziganshin, Mohammad Zafar, John Elefteriades, Hui Zhang, Allen Bale   +7 more
doaj   +1 more source

Copper‐Doped Prussian Blue Nanozymes With Hyaluronic Acid‐Mediated Targeting Alleviate Oxidative Stress and Regulate Cholesterol Handling for Atherosclerosis Therapy

Advanced Science, EarlyView.
CuPB@HA is a CD44‐associated, plaque‐targeted nanozyme that alleviates oxidative stress, inflammation, and lipid accumulation in macrophages. By reducing CD36‐dependent lipid uptake and promoting ABCA1/ABCG1‐mediated cholesterol handling, it improves macrophage function, preferentially accumulates in atherosclerotic lesions, reduces plaque burden, and ...
Jianliang Ou, Ruihua Ji, Qinglu Zang, Mingkang Wang, Lingling Zhou, Yingliang Wei, Di Yang, Yue Wu, Hongxu Zhu, Jianrong Wu, Xiaojun Cai, Wenxian Du, Junjie Cheng, An Zeng, Yuehua Li   +14 more
wiley   +1 more source