Results 101 to 110 of about 551,312 (317)

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

The Development and Pilot Clinical Study of CD147 Targeted Antagonistic Peptide Probe for Tumor Imaging

Advanced Science, EarlyView.
This study establishes [68Ga]Ga‐DOTA‐AP9 as a first‐in‐human CD147‐targeted PET tracer with favorable safety and specific tumor uptake. Tracer accumulation correlates with CD147 expression in patients, enabling noninvasive quantification of CD147‐positive malignancies.
Xiaokun Ma, Rui Guo, Dongfeng Niu, Yufei Song, Zhenyao Zhang, Xiangxi Meng, Lili Mao, Haifeng Huang, Hua Zhu, Zhi Yang, Teli Liu   +10 more
wiley   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Outcome of acute type A aortic dissection: single-center experience from 1998 to 2007 [PDF]

, 2009
Introduction. Acute aortic dissection (AAD) is a serious disease of the aorta with high mortality and morbidity, which requires emergency surgical treatment in order to close the site of the dissection and direct blood flow into the true lumen.
Zizza A., Zaccaria S., GUIDO, Marcello, Pano M., Villani M., the Aortic Dissection Study Group   +5 more
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Paravalvular leak after transcatheter aortic valve implantation

Anatolian Journal of Cardiology, 2020
Orhan Gökalp, Hasan Iner, Yüksel Beşir, Nihan Karakaş Yeşilkaya, Levent Yılık   +4 more
doaj   +1 more source

The Role of 4D Flow MRI-derived Wall Shear Stress in Aortic Disease: A Comprehensive Review

Reviews in Cardiovascular Medicine
Aortic diseases, such as aortic dissection and aortic rupture, often lead to catastrophic complications, significantly increasing morbidity and mortality.
Ying Liu, Xiaolin Mu, Yixin Wang, Zhe Xu, Yang Song   +4 more
doaj   +1 more source

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

The role of neo-sinus reconstruction in aortic valve-sparing surgery [PDF]

, 2017
Aims The aim of this study was to evaluate the clinical and echocardiographic results and the predictors of outcomes in patients undergoing valve‐sparing operation (VSO) at two aortic centers.
Leonard Girardi, Mario Gaudino, Luca Weltert, Umberto Benedetto, Gambardella, Ivancarmine, Ruggero De Paulis, (The Cornell International Consortium for Aortic Surgery (CICAS)), Leonard N. Girardi, Di Franco, Antonio, Benedetto, Umberto, Christopher Lau, ?, ?, (Di Franco), Antonio, (De Paulis), Ruggero, null null, Antonino Di Franco, Weltert, Luca, Girardi, Leonard, Ivancarmine Gambardella, Lau, Christopher, De Paulis, Ruggero, Gaudino, Mario   +21 more
core   +1 more source

DTX3L Inhibits the EMT, Metastasis, and Stem‐Like Features of Gastric Cancer Through Promoting GSK‐3β Dependent SNAI1 Decay

Advanced Science, EarlyView.
This research identifies DTX3L as a critical tumor suppressor that inhibits epithelial‐mesenchymal transition (EMT), invasion and metastasis in gastric cancer. By functioning as an E3 ubiquitin ligase, DTX3L targets the master EMT regulator SNAI1 for GSK‐3β‐dependent proteasomal degradation.
Yang Chen, Zhen Li, Jiajia Shen, Jingyu Lin, Xiaoli Zhao, Rui Zhang, Ying Han, Zhen Wang   +7 more
wiley   +1 more source

Clinical research regional vascular changes and aortic dilatation in pediatric patients with bicuspid aortic valve

, 2022
: Background: Bicuspid aortic valve (BAV) is the most common congenital heart disease, often associated with valve dysfunction, coarctation of the aorta, and ascending aorta dilatation.
Franco-Cereceda, Anders, Andelfinger, Gregor, Rumman, Rawan K., Slorach, Cameron, Mertens, Luc, Mital, Seema, Grattan, Michael, Lopez, Carmen, Fan, Steve, Mohamed, Salah A., Dietz, Harry, Hui, Wei, Loeys, Bart, Larios, Guillermo   +13 more
core