Results 101 to 110 of about 9,640,816 (362)

Vascular Smooth Muscle-Specific Progerin Expression Accelerates Atherosclerosis and Death in a Mouse Model of Hutchinson-Gilford Progeria Syndrome [PDF]

, 2018
Background: Progerin, an aberrant protein that accumulates with age, causes the rare genetic disease Hutchinson-Gilford progeria syndrome (HGPS). Patients who have HGPS exhibit ubiquitous progerin expression, accelerated aging and atherosclerosis, and ...
Andrés Manzano, María J., Andrés, Vicente, Bentzon, Jacob F., Gonzalo, Pilar, Hamczyk, Magda Rita, López Otín, Carlos, Nogales, Paula, Villa Bellosta, Ricardo   +7 more
core   +4 more sources

Alleviation of Aging‐Related Hallmarks in a Mouse Model of Progeria via a Nanoparticle‐Based Artificial Transcription Factor

Advanced Functional Materials, EarlyView.
Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim, Junyeop Kim, Euiyeon Lee, Brandon Conklin, Yannan Hou, Sumin Kim, Yerim Hwang, Ki‐Bum Lee, Jongpil Kim   +8 more
wiley   +1 more source

Biological features of thoracic aortic diseases. Where are we now, where are we heading to: established and emerging biomarkers and molecular pathways.

European Journal of Cardio-Thoracic Surgery, 2013
Thoracic aortic aneurysms (TAAs) and aortic dissections (ADs) are among the main causes of mortality and morbidity in Western countries. For this reason, the diagnosis, prevention and prediction of TAAs and ADs have become a very active area of research;
A. Parolari, E. Tremoli, P. Songia, Alberto Pilozzi, R. di Bartolomeo, F. Alamanni, C. Mestres, D. Pacini   +7 more
semanticscholar   +1 more source

Material transport in the left ventricle with aortic valve regurgitation

, 2018
This experimental in vitro work investigates material transport properties in a model left ventricle in the case of aortic regurgitation, a valvular disease characterized by a leaking aortic valve and consequently double-jet filling within the elastic ...
Di Labbio, Giuseppe, Kadem, Lyes, Vétel, Jérôme   +2 more
core   +1 more source

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source

Embedded 3D‐Coaxial Bioprinting of Stenotic Brain Vessels with a Mechanically Enhanced Extracellular Matrix Bioink for Investigating Hemodynamic Force‐Induced Endothelial Responses

Advanced Functional Materials, EarlyView.
In this study, a physically enhanced vascular dECM bioink and used 3D‐coaxial bioprinting are developed to fabricate mature brain blood vessels for cerebral atherosclerosis research. This model demonstrates that vascular geometry‐induced hemodynamic changes trigger vascular inflammation, ensuring its potential for cerebrovascular research.
Wonbin Park, Min‐Ju Choi, Jae‐Seong Lee, Minjun Ahn, Wonil Han, Ge Gao, Dong‐Woo Cho, Byoung Soo Kim   +7 more
wiley   +1 more source

New Insights Into Aortic Diseases

Aorta, 2013
The current state of research and treatment on aortic diseases was discussed in the “3rd International Meeting on Aortic Diseases” (IMAD3) held on October 4–6, 2012, in Liège, Belgium.
H. Kuivaniemi, N. Sakalihasan, F. Lederle, Gregory T. Jones, J. Defraigne, N. Labropoulos, V. Legrand, J. Michel, C. Nienaber, M. Radermecker, J. Elefteriades   +10 more
semanticscholar   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

Supra-aortic vessel reconstruction in total arch replacement for acute type A dissection: Comparison of en bloc and separate graft techniques

Asian Journal of Surgery, 2019
Summary: Objective: To compare the outcomes of the en bloc and branched graft techniques for supra-aortic vessel reconstruction in total arch replacement (TAR) for acute type A aortic dissection (ATAAD).
Yi Lin, Wei-Guo Ma, Jun Zheng, Xiao-Yan Xing, Xu-Dong Pan, Jun-Ming Zhu, Li-Zhong Sun   +6 more
doaj  

Approach to aortic aortic valve diseases in the elderly

Turk Kardiyoloji Dernegi Arsivi-Archives of the Turkish Society of Cardiology, 2017
Aortic valve diseases are the most common among the valvular heart diseases. Significant increases in the frequency of degenerative aortic sclerosis and aortic stenosis (AS) are observed, particularly with aging of the population and diminished rheumatic heart disease.
Bozkurt, Engin, Ayhan, Huseyin
openaire   +4 more sources