Results 111 to 120 of about 2,421,495 (257)

Diseases of the Aorta [PDF]

, 2019
Aortic diseases are very common, however , for many years they might be undiscovered. It is very important to raise awareness of aortic diseases in order to provide a highest quality patient care through education, research and ...
Mazalkova, Maria
core   +1 more source

The Deubiquitinase UCHL1 Drives Susceptibility to Atrial Fibrillation by Stabilizing CaMKII‐δ

Advanced Science, EarlyView.
UCHL1 is highly upregulated in mice and patients with AF. UCHL1 directly binds to and removes K48‐linked polyubiquitin chains from CaMKII‐δ at K251 and enhances CaMKII‐δ stability, which activates RyR2, disrupts Ca2+ handling, and promotes AF. These findings establish UCHL1 as a critical regulator of CaMKII‐δ stability and AF‐related Ca2+ handling ...
Hai‐Lian Bi, Yu‐Hui Gu, Kai‐Wen Ren, Xiao‐Hong Yu, Yun‐Long Xia, Xiao‐Lei Yang, Hui‐Hua Li   +6 more
wiley   +1 more source

Outcomes of Patients with Aortic Diseases Treated by Antiemetic Drug, Who Were Transported by a Physician-staffed Helicopter in Japan

Journal of Emergencies, Trauma and Shock
Introduction: Aortic diseases have been observed to manifest the symptoms such as nausea and vomiting. We conducted a retrospective investigation to ascertain the clinical significance of antiemetic drug use for patients with aortic diseases transported ...
Youichi Yanagawa, Hiroki Nagasawa, Chihiro Maekawa, Noriko Tanaka, Michika Hamada, Soichiro Ota, Hiromichi Ohsaka, Kazuhiko Omori   +7 more
doaj   +1 more source

Salvianolic Acid a Disrupts the HSP90α‐AKT‐PERK Ternary Complex to Alleviate Atherosclerosis by Activating Endoplasmic Reticulum Stress of Senescent Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Salvianolic acid A (SAA) selectively induces senescent vascular smooth muscle cell apoptosis, alleviating atherosclerosis. Mechanistically, SAA targets heat shock protein 90 alpha (HSP90α) to disrupt the protein inase B (AKT)‐PRKR‐Like Endoplasmic Reticulum Kinase (PERK) scaffold, driving ubiquitin‐proteasome‐dependent AKT degradation.
Xiuya Guan, Mengkai Lu, Xinhai Cui, Dawei Zhang, Lei Zhang, Lin Lin, Yuan Li, Yuanlong Hu, Chao Li   +8 more
wiley   +1 more source

Aortic disease and peripheral artery disease

Journal of Geriatric Cardiology
The Annual Report on Cardiovascular Health and Diseases in China (2022) intricate landscape of car-diovascular health in China. In connection with the previous section, this 10th section of the report offers a comprehensive analysis of aortic disease and peripheral artery disease.
openaire   +2 more sources

Exaggerated Autophagy in Stanford Type A Aortic Dissection: A Transcriptome Pilot Analysis of Human Ascending Aortic Tissues

, 2020
Stanford type A aortic dissection (TAAD) is one of the most dangerous diseases of acute aortic syndrome. Molecular pathological studies on TAAD can aid in understanding the disease comprehensively and can provide insights into new diagnostic markers and ...
Yan Liu, Can Xu, Qing Zhou, Xiyu Zhu, Xinlong Tang, Dongjin Wang, Junxia Wang, Jie Du, Yali Wang, Zeyi Zhou   +9 more
core   +1 more source

Ilexoside K Ameliorates Atherosclerosis by Suppressing CD72hi Macrophages and Blocking CXCL12–CXCR4 Axis to Inhibit Endothelial Pyroptosis

Advanced Science, EarlyView.
CD72hi macrophages drive endothelial pyroptosis and accelerate atherosclerosis through CXCL12–CXCR4‐mediated immune–vascular crosstalk. Ilexoside K suppresses this pathogenic communication by modulating CXCR4‐dependent endothelial responses, reducing inflammation and plaque progression. These findings reveal a macrophage–endothelial regulatory axis and
Xingling He, Sijing Li, Jiahui Chen, Liyu Lin, Xinyu Li, Xiaojiao Zhang, Yihui Zhang, Xingling Chen, Jinjian Guo, Zhongqi Yang, Lu Lu, Shihao Ni   +11 more
wiley   +1 more source

Association of triglyceride-glucose index and triglyceride–glucose–body mass index with all-cause mortality in critically ill patients with aortic disease: A retrospective cohort study

JTCVS Open
Objective: Aortic diseases represent a group of life-threatening vascular disorders that impose a substantial socioeconomic burden. This study aimed to investigate the association between insulin resistance indices and all-cause mortality in with aortic ...
Jie Liu, MD, Zhaoxin Qian, MD, PhD, Jing Cao, MD, PhD   +2 more
doaj   +1 more source

Extracellular Vesicle Packaged TDP43 Derived From ECs Exacerbates Cigarette Tar‐Related Atherosclerosis Progression via Enhancing Macrophage Extracellular Traps

Advanced Science, EarlyView.
Cigarette tar triggers EC‐derived EVs carrying TDP43, which binds VDAC1 to boost MAMs, mitochondrial Ca2+ overload, and METs formation in macrophages, accelerating smoking‐related AS progression, while retinoic acid binds TDP43 to block this pathogenic cascade.
Xinxin Zhu, Yuwu Chen, Wei Meng, Biyi Xu, Junke Mou, Xiaolin Liu, Mengyang Wang, Qishuo Gu, Qianhui Sun, Man Li, Chen Zhao, Ming Zeng, Ying Lv, Boling Yi, Sheng Qu, Xiaoxuan Bai, Ji Li, Xing Luo, Sining Hu, Bo Yu, Haibo Jia   +20 more
wiley   +1 more source

Valvular and aortic diseases in osteogenesis imperfecta

, 2013
Osteogenesis imperfecta (OI) is an inheritable connective tissue disorder caused by defective collagen synthesis with the principal manifestations of bone fragility. OI has been associated with left sided valvular regurgitation and aortic dilation. Valve
Clarke, Sophie, Parsonage, Will, Parsonage, William, Fayers, Trevor, Lamanna, Arvin   +4 more
core   +1 more source