Results 121 to 130 of about 2,421,495 (257)

A Spatiotemporal Single‐Cell Atlas Uncovers Dysregulated ECM Dynamics and Septal Remodeling Arrest in Human Ventricular Septal Defects

Advanced Science, EarlyView.
Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang, Lun Zhu, Ze Sun, Ruolin Jia, Ziming Wang, Jiayao Zhao, Bohao Liu, Haiqing Xiong, Xiaowei Yu, Yanzhu Yue   +9 more
wiley   +1 more source

Case report: Diagnosis of a double aortic arch in the primary care setting

Journal of Family Medicine and Primary Care
A double aortic arch is a rare congenital heart anomaly not typically diagnosed in adults. It can present with nonspecific symptoms including dysphagia, a cough, and hoarseness which can lead to a delay in diagnosis or misdiagnosis.
Mary Chick
doaj   +1 more source

NCOA4 Accelerates Abdominal Aortic Aneurysm Formation by Regulating Macrophage Activation and Ferroptosis via STAT1–CH25H Axis

Advanced Science, EarlyView.
Under pathological stimulation, NCOA4 in macrophages interacts with STAT1 to promote CH25H transcription. The subsequent increase in 25‐HC production activates macrophages, triggers inflammatory responses and ferroptosis, and accelerates the progression of AAA.
Zhinan Wu, Yuxuan Qian, Wenyi Xu, Fei Liao, Xueliang Liu, Xiao Kuang, Guqing Luo, Xinjie He, Lixian Jiang, Song Ding   +9 more
wiley   +1 more source

Age-related diseases; degenerative aortic valve disease and osteoarthritis

, 2010
Objective: To examine the relationship between degenerative aortic valve disease and osteoarthritis Background: Degenerative aortic valve disease (DAVD) and osteoarthritis (OA) are age-related degenerative diseases whose pathogenesis involves mechanical ...
Ozden, G., DURMUŞ, İSMET, CANSU, AYŞEGÜL, Tosun, M., Kiris, A., KARKUCAK, MURAT, Capkin, E.   +6 more
core  

Using Decision Tree to Analyze Relation between Aortic Aneurysm and Chronic Diseases in Clinical Application

, 2013
Aortic aneurysm is caused by sclerosis of aortic wall. However, bad habits and chronic disease would be caused sclerosis of aortic wall. Therefore, bad habits and chronic diseases would possible affect aortic aneurysm, even after surgery.
Chou, Kuang-Yi; Shih, Chun-Che; Keh, Huan-Chao; Yu, Po-Yuan; Cheng, Yuan-Cheng; Huang, Nan-Ching, Yu, Po-Yuan, Nan-Ching Huang, Yuan-Cheng Cheng, Huan-Chao Keh, Po-Yuan Yu, Kuang-Yi Chou, Chun-Che Shih   +7 more
core   +1 more source

Lactate Signal: Modulator of Cellular Energy Production and Anabolism

Advanced Science, EarlyView.
Compartmentalized lactate signaling provides a spatial framework for understanding how lactate‐rich states are generated, transported, sensed, and translated into biological outputs. This Review integrates extracellular, cytosolic, mitochondrial‐associated, and nuclear lactate mechanisms to explain how lactate shapes metabolic adaptation, immune ...
Han Wang, Si‐Yuan Yang, Wei Xu
wiley   +1 more source

Using Decision Tree to Analyze Relation between Aortic Aneurysm and Chronic Diseases in Clinical Application

, 2016
Aortic aneurysm is caused by sclerosis of aortic wall. However, bad habits and chronic disease would be caused sclerosis of aortic wall. Therefore, bad habits and chronic diseases would possible affect aortic aneurysm, even after surgery.
Chou, Kuang-Yi;Shih, Chun-Che;Keh, Huan-Chao;Yu, Po-Yuan;Cheng, Yuan-Cheng;Huang, Nan-Ching
core   +1 more source

Checkpoint‐Directed Glycoengineering Reprograms the Vascular Lumen for Siglec‐Mediated Immune Regulation

Advanced Science, EarlyView.
Checkpoint‐directed glycoengineering installs sialylated ligands on the donor vascular lumen during ex vivo preservation, creating a localized Siglec‐7/9‐engaging interface. The engineered glycocalyx suppresses immune‐cell activation, complement deposition, and microvascular injury in arterial and kidney allografts while preserving endothelial ...
Md Mohosin Rana, Javairia F. Rahim, Aaron P. Bernstein, Peyman Malek Mohammadi Nouri, Lyann Sim, Winnie Enns, Jenice M. Dumlao, Haiming D. Luo, Irina Chafeeva, Hong‐Ming Chen, Aizhou Wang, Jiao‐Jing Wang, Edward N. Schmidt, Zheng Jenny Zhang, Marcelo Cypel, Christopher Nguan, Matthew S. Macauley, Stephen G. Withers, Jonathan C. Choy, Jayachandran N. Kizhakkedathu   +19 more
wiley   +1 more source

Evaluation of Aortic Diseases Using Four-Dimensional Flow Magnetic Resonance Imaging

Vascular Specialist International
The complex hemodynamic environment within the aortic lumen plays a crucial role in the progression of aortic diseases such as aneurysms and dissections.
Hyun Jung Koo, Hojin Ha, Gyu-Han Lee, Jong En Lee, Sang-hyub Park, Kyoung-jin Park, Joon-Won Kang, Dong Hyun Yang   +7 more
doaj   +1 more source

Effects of aortic valve diseases on pressure profiles in selected locations of the human arterial system

, 2017
Aortic valve diseases such as aortic stenosis and aortic regurgitation, are the most frequent valvular heart diseases. The lesions in the valves affect circulation in the whole arterial system. We study the effects with the use of a 1-D model in which an
Piotr Zieliński, Marcin Majka, Angelo Taibi, Giacomo Gadda   +3 more
core   +1 more source