Role of p38 MAPK in Atherosclerosis and Aortic Valve Sclerosis [PDF]
International Journal of Molecular Sciences, 2018 Atherosclerosis and aortic valve sclerosis are cardiovascular diseases with an increasing prevalence in western societies. Statins are widely applied in atherosclerosis therapy, whereas no pharmacological interventions are available for the treatment of aortic valve sclerosis.
Reustle, Anna, Torzewski, Michael
europepmc +5 more sources
Aortic Valve Sclerosis and Degenerative Valve Disease in a Nigerian Population: An Echocardiographic Study [PDF]
Global HeartBackground: The burden of degenerative valve disease is increasing globally because of population aging. However, data on this condition is scarce in Nigeria and across Africa.
Olugbenga O. Abiodun +2 more
doaj +2 more sources
Pro-Calcifying Role of Enzymatically Modified LDL (eLDL) in Aortic Valve Sclerosis via Induction of IL-6 and IL-33 [PDF]
Biomolecules, 2023 One of the contributors to atherogenesis is enzymatically modified LDL (eLDL). eLDL was detected in all stages of aortic valve sclerosis and was demonstrated to trigger the activation of p38 mitogen-activated protein kinase (p38 MAPK), which has been ...
Annemarie Witz +5 more
doaj +2 more sources
Osteopontin-expressing valvular interstitial cell subpopulation as a driver of extracellular matrix remodeling in aortic valve disease [PDF]
Frontiers in Cardiovascular MedicineIntroductionAortic valve disease (AVD) is a cardiovascular disorder highly prevalent in the elderly population. Aortic valve leaflets suffer hardening due to extracellular matrix (ECM) remodeling and subsequent calcification, leading to impaired blood ...
Răzvan D. Macarie +5 more
doaj +2 more sources
Pulmonary artery aneurysm and tuberous sclerosis: case report [PDF]
Einstein (São Paulo)Tuberous sclerosis is a rare and serious genetic disease, classically characterized by epilepsy, mental deficiency, and sebaceous adenomas; however, it may also be associated with the development of multiple tumors in various organs.
Heli Vieira Brandão +2 more
doaj +3 more sources
Clinical Relevance of Plasma Endogenous Tissue-Plasminogen Activator and Aortic Valve Sclerosis: Performance as a Diagnostic Biomarker [PDF]
Frontiers in Cardiovascular Medicine, 2020 Background: Aortic valve sclerosis (AVSc), a common precursor to calcific aortic valve disease, may progress into advanced aortic stenosis with hemodynamic instability. However, plasma biomarkers of such a subclinical condition remain lacking.
Zhongli Chen +9 more
doaj +2 more sources
Association Between Aortic Valve Sclerosis and Clonal Hematopoiesis of Indeterminate Potential [PDF]
Annals of Laboratory MedicineThe mechanism and medical treatment target for degenerative aortic valve disease, including aortic stenosis, is not well studied. In this study, we investigated the effect of clonal hematopoiesis of indeterminate potential (CHIP) on the development of aortic valve sclerosis (AVS), a calcified aortic valve without significant stenosis.Participants with ...
Minkwan Kim +8 more
openaire +3 more sources
Risk for acquired coronary artery disease in genetic vs. congenital thoracic aortopathy
Frontiers in Cardiovascular Medicine, 2023 ObjectivePatients with Marfan syndrome (MFS) and patients with a bicuspid aortic valve (BAV) have a significantly increased risk to develop thoracic aortopathy.
Onur B. Dolmaci +13 more
doaj +1 more source
Relationship Between Platelet Indices and Aortic Valve Sclerosis [PDF]
Clinical and Applied Thrombosis/Hemostasis, 2009 Objective: Aortic valve sclerosis (AVS) is a progressive disease that is characterized by aortic valve thickening without causing significant narrowing and in which pathology resembles atherosclerotic coronary heart disease. We aimed to evaluate the relationship between AVS and platelet indices including mean platelet volume (MPV), platelet ...
Murat, Sucu +4 more
openaire +2 more sources
Frontiers in Cardiovascular Medicine, 2023 BackgroundCurrent mouse models still have limitations in studying aortic valve stenosis (AVS). A suitable animal model bearing a close resemblance to the pathophysiological processes of humans needs to be developed.
Dezhong Wen +7 more
doaj +1 more source