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Progress in Cardiovascular Diseases, 2020 There is a growing need to develop a common language when referring to a frequent and heterogeneous condition such as the congenital bicuspid aortic valve and its aortopathy.
Jeroen Bax
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Imaging of Genetic Thoracic Aortopathy
RadioGraphics, 2022Aortopathy is a term most commonly used to describe a group of genetic diseases that predispose patients to an elevated risk of aortic events including aneurysm and acute aortic syndrome. Types of genetic aortopathy are classified as either heritable or congenital, with heritable thoracic aortic disease (HTAD) further subclassified into syndromic HTAD ...
Kacie L. Steinbrecher +7 more
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Genetic Biomarkers in Aortopathy
Biomarkers in Medicine, 2013The field of aortopathy, in common with other genomic disorders, is undergoing a revolution. This is largely driven by the implementation of newer forms of genetic sequencing (massively parallel or next-generation sequencing). Advantages conferred by this technology include reduced costs, reduced sequencing time and the ability to simultaneously test ...
Gillian, Rea, Fiona J, Stewart
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Seminars in Perinatology, 2014
Up to half of all aortic dissections and ruptures in women younger than 40 years are associated with pregnancy. In pregnancy, women with aortic disease such as arteritis and aortitis are at significant risk of aneurysmal formation and dissection with potential for catastrophic outcomes.
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Up to half of all aortic dissections and ruptures in women younger than 40 years are associated with pregnancy. In pregnancy, women with aortic disease such as arteritis and aortitis are at significant risk of aneurysmal formation and dissection with potential for catastrophic outcomes.
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Cardiovascular Outcomes in Aortopathy
Journal of the American College of Cardiology, 2022The GenTAC (Genetically Triggered Thoracic Aortic Aneurysm and Cardiovascular Conditions) Registry enrolled patients with genetic aortopathies between 2007 and 2016.The purpose of this study was to compare age distribution and probability of elective surgery for proximal aortic aneurysm, any dissection surgery, and cardiovascular mortality among ...
Holmes, Kathryn W +19 more
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Inherited aortopathy: an overview
British Journal of Cardiac Nursing, 2023This article is the fourth instalment of a wider series looking at cardiac genetic concepts. Inherited aortopathies are a group of syndromic and non-syndromic genetic conditions that affect the aorta. Aortopathies can lead to sudden cardiac death through aortic aneurysm rupture, especially in individuals whose aortopathy is undiagnosed.
Fortunate Mamombe +7 more
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Genetic testing for aortopathies
Current Opinion in Cardiology, 2019Although the majority of thoracic aortic aneurysms and dissections (TAD) in the overall population are mainly related to arterial hypertension and atherosclerosis, Heritable Thoracic Aortic Disease (HTAD) are increasingly recognized, especially in younger individuals.
Julie, De Backer +2 more
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2017
Transcatheter stent deployment within the aorta is generally used for two purposes: (1) relief of aortic obstruction as seen in aortic coarctation and (2) the use of covered stents to exclude an aneurysm or pseudoaneurysm of the aorta. For the purpose of relieving obstruction, balloon angioplasty alone is associated with reasonable short-term ...
Joanna Ghobrial, Jamil Aboulhosn
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Transcatheter stent deployment within the aorta is generally used for two purposes: (1) relief of aortic obstruction as seen in aortic coarctation and (2) the use of covered stents to exclude an aneurysm or pseudoaneurysm of the aorta. For the purpose of relieving obstruction, balloon angioplasty alone is associated with reasonable short-term ...
Joanna Ghobrial, Jamil Aboulhosn
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Aortopathy in Congenital Heart Disease
Cardiology Clinics, 2020Aortic dilatation is common in patients with congenital heart disease and is seen in patients with bicuspid aortic valve and those with conotruncal congenital heart defects. It is important to identify patients with bicuspid aortic valve at high risk for aortic dissection.
Timothy B, Cotts +3 more
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Aortopathy in Marfan syndrome: an update
Cardiovascular Pathology, 2014Marfan syndrome (MFS) is an inherited autosomal dominant multisystem disease caused by mutations in the FBN1 gene encoding fibrillin-1, an extracellular matrix glycoprotein widely distributed in mesenchymal-derived tissues that provide a scaffold for elastin deposition.
Romaniello, F +7 more
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