Results 61 to 70 of about 2,098 (173)

Successful Treatment with Intravenous Cyclophosphamide for Refractory Adult-Onset Still’s Disease

Case Reports in Rheumatology, 2015
We report a 64-year-old female case of intractable adult-onset Still’s disease (AOSD). Initial high-dose steroid therapy combined with cyclosporin A was ineffective against macrophage-activation syndrome (MAS), which was accompanied by the systemic type ...
Yoshika Tsuji, Nozomi Iwanaga, Anna Adachi, Kinuyo Tsunozaki, Yasumori Izumi, Yuji Moriwaki, Kazuhiro Kurohama, Masahiro Ito, Atsushi Kawakami, Kiyoshi Migita   +9 more
doaj   +1 more source

Cytomegalovirus Infection May Trigger Adult-Onset Still's Disease Onset or Relapses

Frontiers in Immunology, 2019
Previous studies have revealed that several micro-organisms, especially DNA viruses, have been associated with adult-onset Still's disease (AOSD). However, there are no studies on the relationship between the presence of viral infections in AOSD patients
Jinchao Jia, Hui Shi, Mengguo Liu, Tingting Liu, Jieyu Gu, Liyan Wan, Jialin Teng, Honglei Liu, Xiaobing Cheng, Junna Ye, Yutong Su, Yue Sun, Wen Gong, Chengde Yang, Qiongyi Hu   +14 more
doaj   +1 more source

Serum Cytokine Profiling Differentiates Underlying Diseases in Cytokine Storm Syndrome

Arthritis &Rheumatology, Volume 78, Issue 2, Page 463-474, February 2026.
Serum cytokine profiling was performed using Luminex (48 cytokines) and ELISA (5 cytokines). Assessment of key cytokines (IFN‐α, IL‐18, IL‐6, CXCL9) delineated five dominant inflammatory patterns: I, IFN‐α–dominant CSS; II, IL‐18–dominant CSS; III, IL‐6–dominant CSS; IV, IFN‐γ–dominant CSS; and V, IL‐6 & IFN‐γ intermediate CSS.
Shuya Kaneko, Maho Hatano, Asami Shimbo, Futaba Miyaoka, Hitoshi Irabu, Yuko Akutsu, Yuko Hayashi, Mao Mizuta, Yasuo Nakagishi, Keiji Akamine, Naomi Iwata, Kenji Furuno, Takayuki Tanaka, Kazuyuki Ueno, Shuhei Fujita, Koji Yokoyama, Toshinori Minato, Kazushi Izawa, Takahiro Yasumi, Tadashi Matsubayashi, Tadashi Hosoya, Hiroki Nishikawa, Junya Fujimura, Ryoko Asano, Yuko Sugita, Kenichi Watanabe, Anna Kobayashi, Takuya Endo, Katsuhide Eguchi, Ryuta Nishikomori, Ryuhei Yasuoka, Takaki Asano, Miyako Kanno, Kazuya Hamada, Yuji Fujita, Daisuke Hayashi, Shojiro Watanabe, Takeshi Shiba, Shinsuke Yasuda, Masaaki Mori, Hirokazu Kanegane, Masatoshi Takagi, Masaki Shimizu   +42 more
wiley   +1 more source

AOSD Ontology 1.0

, 2005
This report presents a Common Foundation for Aspect-Oriented Software Development. A Common Foundation is required to enable effective communication and to enable integration of activities within the Network of Excellence. This Common Foundation is realized by developing an ontology, i.e.
van den Berg, Klaas Gerrit, Conejero, José María, Chitchyan, R   +2 more
openaire   +1 more source

A Randomized, Double‐Blind, Placebo‐Controlled, Multiple Ascending Dose Phase 1 Study of Firsekibart in Chinese Healthy Participants

Clinical Pharmacology in Drug Development, Volume 15, Issue 2, February 2026.
Abstract Firsekibart is an anti‐IL‐1β monoclonal antibody for treating acute gout flares in adults. This randomized, double‐blind, placebo‐controlled study assessed the safety, pharmacokinetics, pharmacodynamics, and immunogenicity of multiple ascending doses of firsekibart in healthy Chinese adults.
Xiaolan Yong, Xiaolin Du, Xiao Li, Yushi Chen, Xiaoyan Zhu, Tianhong Luo, Qian Xu   +6 more
wiley   +1 more source

Disentangling Crosscutting in AOSD: Formalization based on a Crosscutting Pattern.

, 2006
Crosscutting is usually described in terms of scattering and tangling. However, the distinction between these concepts is vague, which could lead to ambiguous statements. Sometimes, precise definitions are required, e.g. for the formal identification of crosscutting concerns.
Conejero, José María, van den Berg, Klaas Gerrit, Hernández, Juan   +2 more
openaire   +2 more sources

High Neutrophil Alkaline Phosphatase Activity in Adult-Onset Still’s Disease

Rheumatology and Therapy
Introduction Adult-onset Still’s disease (AOSD) is an autoinflammatory disorder characterized by reactive neutrophilia and dysregulated cytokine release.
Nana Ding, Haiye Ren, Jialin Teng, Xiaobing Cheng, Junna Ye, Yutong Su, Hui Shi, Qiongyi Hu, Yue Sun, Jianfen Meng, Huihui Chi, Zhuochao Zhou, Jinchao Jia, Chengde Yang, Hong-Lei Liu   +14 more
doaj   +1 more source

Application of the international league against rheumatism classification criteria for systemic juvenile idiopathic arthritis as a prognostic factor in patients with adults-onset Still’s disease

Pediatric Rheumatology Online Journal, 2018
Background Adult-onset Still’s disease (AOSD) is an adult form of systemic juvenile idiopathic arthritis (JIA) that differs from the latter in its classification.
Ji Won Yang, Eunyoung Lee, Ji-Yeon Seo, Ju-Yang Jung, Chang-Hee Suh, Hyoun-Ah Kim   +5 more
doaj   +1 more source

Characteristic patterns of HLA presentation and T cell differentiation in adult-onset Still’s disease

International Journal of Immunopathology and Pharmacology, 2018
We examined the expression of human leukocyte antigen (HLA) and composition of differentiated T cells in the peripheral blood to understand the characteristics of the immune changes in patients with adult-onset Still’s disease (AOSD). This study enrolled
Ju-Yang Jung, Bunsoon Choi, Hasan MD Sayeed, Chang-Hee Suh, Ye Won Kim, Hyoun-Ah Kim, Seonghyang Sohn   +6 more
doaj   +1 more source

A retrospective analysis of 26 cases of adult-onset Still's disease

Pifu-xingbing zhenliaoxue zazhi, 2019
Objective: To analyze the clinical characteristics, laboratory indexes, treatments and outcome of the adult-onset Still's disease(AOSD). Methods: Retrospective analysis of clinical data was made in 26 cases of AOSD from Jan. 2010 up to present.
Yu LIU, Jin CHEN
doaj   +1 more source