Results 121 to 130 of about 246,547 (300)

Apathy in Older Adults With and Without Dementia: An Integrative Review of Barriers and Facilitators to Care

SAGE Open
Despite the detrimental impact of apathy on the cognition, functional abilities, and quality of life of older people, it is often under-rated and under-managed.
Aderonke Agboji, Shannon Freeman, Davina Banner, Annie Duchesne, Joshua Armstrong, Melinda Martin-Khan   +5 more
doaj   +1 more source

Memantine treatment in individuals with GRIN gain‐of‐function variants is associated with improvements in behavior, development, and seizure frequency

Epilepsia, EarlyView.
Abstract Objective GRIN‐related disorders due to pathogenic variants in GRIN1, GRIN2A, GRIN2B, or GRIN2D genes are associated with altered N‐methyl‐D‐aspartate receptor (NMDAR) function. Functional changes include gain (GoF) and loss of receptor function (LoF). Clinical reports describing the use of the NMDAR blocker memantine in GRIN‐related disorders
Maike Karnstedt, Riley E. Perszyk, Scott J. Myers, Ellington McDaniels, Marta Somorai, Ingo Borggraefe, Danielle C. M. Veenma, An‐Sofie Schoonjans, Pasquale Striano, Tadeu A. Fantaneanu, Steffen Syrbe, Kristen Park, Wenjuan Chen, Hongjie Yuan, Stephen F. Traynelis, Timothy A. Benke, Johannes R. Lemke, Ilona Krey   +17 more
wiley   +1 more source

Apathy and affective symptoms associated with elevated plasma neurofilament light but not p‐tau181 in Alzheimer's disease

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION Apathy and affective neuropsychiatric symptoms (NPS) are prevalent in Alzheimer's disease (AD), yet their neurobiological cause is still unclear.
Matthew J. Y. Kang, Dhamidhu Eratne, Samantha M. Loi, Christa Dang, Alexander F. Santillo, Henrik Zetterberg, Kaj Blennow, Philip B. Mitchell, Malcolm Hopwood, Charles B. Malpas, Dennis Velakoulis   +10 more
doaj   +1 more source

Dimensions of Apathy in Parkinson's Disease: Exploratory Factor Analysis of the Apathy Scale

Journal of Parkinson’s Disease, 2012
Apathy, an intrinsic disorder of motivation, can manifest in cognitive, affective, and behavioral domains. Recent attempts to formalize diagnostic criteria for apathy have advocated this triadic structure.
Daniel B. Kay, Lindsey Kirsch-Darrow, Laura B. Zahodne, Michael S. Okun, Dawn Bowers   +4 more
doaj   +1 more source

Fenfluramine in SCN1A‐related GEFS+: A multicenter observational study on efficacy, EEG improvement, and tolerability

Epilepsia Open, EarlyView.
Abstract The SCN1A gene is implicated in a broad spectrum of epilepsy phenotypes, ranging from self‐limited genetic epilepsy with febrile seizures plus (GEFS+) to severe developmental and epileptic encephalopathies such as Dravet syndrome (DS). While fenfluramine (FFA) has demonstrated strong efficacy in DS, its role in SCN1A‐related epilepsies beyond ...
Giovanni B. Dell'Isola, Alice Muda, Lucio Giordano, Renzo Guerrini, Alessandra Boncristiano, Nicola Pietrafusa, Maria Polselli, Francesca Bisulli, Francesca Ragona, Antonella Riva, Pasquale Striano, Domenica Immacolata Battaglia, Federico Vigevano   +12 more
wiley   +1 more source

Therapists' Attitudes and Exclusion Criteria for Prolonged Exposure and EMDR in Patients With Eating Disorders and PTSD

European Eating Disorders Review, EarlyView.
ABSTRACT Objective A significant proportion of patients with eating disorders (EDs) also meet criteria for posttraumatic stress disorder (PTSD). Guidelines recommend exposure‐based treatments for PTSD, including prolonged exposure (PE) and eye movement desensitisation and reprocessing (EMDR).
J. van der Starre, M. de Jong, R. A. de Kleine, C. V. Voogt, M. Schoorl, H. W. Hoek   +5 more
wiley   +1 more source

Anthropologist, heal thyself: Toward an anthropology of healing through relational interbeing

Feminist Anthropology, EarlyView.
Abstract I call for an anthropology that confronts its own woundedness. Anthropologists often bear witness to suffering but rarely examine how our own grief, trauma, and institutional distress shape the affective tone of our work. Drawing on fieldwork with Runa (Quechua) women affected by forced sterilization in Peru and guided by my collaborator and ...
Lucía Isabel Stavig
wiley   +1 more source

Modafinil in Post-Traumatic Brain Injury Apathy: A Sleeping Giant?

BJPsych Open
Aims Apathy is a complex clinical, neurobehavioural and neurobiological construct that occurs across a range of neuropsychiatric disorders. Apathy is defined as persistent, diminished motivation with impairments in goal-directed behaviour, thought ...
Kok Keong Leong, Seth Mensah
doaj   +1 more source

The Depth‐Specific Effects of Acupuncture for Post‐Stroke Gastroparesis: Protocol for a Randomized Controlled Trial of Deep Versus Superficial Needling

Gut Medicine, EarlyView.
ABSTRACT Background Post‐stroke gastroparesis (GP) is a debilitating complication that severely impairs quality of life. Although abdominal acupuncture is widely used, robust evidence regarding its efficacy, particularly concerning the critical parameter of the needling depth, is still lacking.
Xiangcheng Wei, Can Wang, Yuan Qin, Lanping Li, Shiqing Zhao, Yee Hwee Cheong, Yang Guo, Lingyong Xiao, Xiaoyu Dai   +8 more
wiley   +1 more source

Current Apathy for Coming Anarchy: Building the Special Court for Sierra Leone [PDF]

, 2001
Part I of this Article examines the chronology of the decade-long conflict in Sierra Leone. It provides an illuminating backdrop against which the Special Court may be assessed and highlights particular features that the institutional design of the ...
Fritz, Nicole, Smith, Alison
core   +2 more sources