Results 161 to 170 of about 69,987 (253)

7 T MRI Connectivity‐Guided Reprogramming Improves Deep Brain Stimulation Motor Outcome in Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established treatment for Parkinson's disease (PD). Using 7‐Tesla (7 T) MRI connectivity analysis to visualize the patient‐specific STN motor subdivision, we hypothesize that reprogramming patients who are stimulated outside of this subdivision can improve their ...
Yarit Wiggerts, Annabel van der Weide, Rick Schuurman, Pepijn van den Munckhof, Rob MA de Bie, Martijn Beudel, Maarten Bot   +6 more
wiley   +1 more source

Lower social participation and physical activity in patients with craniopharyngioma or CNS germ cell tumor: Their association with apathy. [PDF]

PCN Rep
Komaki M, Arakawa Y, Ueda K, Umeda K, Ueno T, Tanji M, Mineharu Y, Funaki T, Kikuchi T, Murai T, Tabata A.   +10 more
europepmc   +1 more source

Longitudinal Changes in Subjective Well‐Being and Loneliness in Parkinson's Disease and Focal/Segmental Craniocervical Dystonia

Movement Disorders Clinical Practice, EarlyView.
Abstract Background The longitudinal changes of subjective well‐being (SWB) in Parkinson's disease (PD) and focal/segmental craniocervical dystonia (FSCD) are poorly understood. Methods Fifty‐three people with PD and 41 with FSCD completed questionnaires assessing various aspects of SWB (subjective happiness, hope, meaning in life, life satisfaction ...
Suzette Shahmoon, Dejan Georgiev, Paul Jarman, Kailash Bhatia, Patricia Limousin, Marjan Jahanshahi   +5 more
wiley   +1 more source

Multimodal Neuroimaging Mechanisms of Apathy in Alzheimer's Disease: A Narrative Review of Structural, Functional, and Molecular Evidence. [PDF]

Int J Gen Med
You X, Guo Z.
europepmc   +1 more source

From Uncertainty to Pathogenicity: Resolving a CSF1R Variant of Uncertain Significance Using Long‐Read Transcriptomics

Movement Disorders, EarlyView.
Abstract Background CSF1R‐related disorder (CSF1R‐RD) is a severe autosomal dominant leukoencephalopathy characterized by progressive cognitive, neuropsychiatric, and motor decline. Although genetic testing is widely available, numerous likely pathogenic variants in CSF1R frequently remain classified as variants of uncertain significance (VUS ...
Charles Wade, Kylie Montgomery, Gabriela E. Jones, Peter Sellars, Akram A. Hosseini, Simon Paine, Henry Houlden, Mina Ryten, David S. Lynch   +8 more
wiley   +1 more source

Non-Pharmacological Interventions for Managing Apathy in Older Adults with Neurocognitive Disorders: A Systematic Review of Randomized Controlled Trials. [PDF]

Brain Sci
Siarkos K, Politis AM, Politis AA, Smyrnis N, Papageorgiou C, Prentakis A, Gournellis R, Katirtzoglou E, Theleritis C.   +8 more
europepmc   +1 more source

Hyperhomocysteinemia and Vitamin B Deficiency as Potential Aggravating Factors in Huntington's Disease: A Prospective Monocentric Study

Movement Disorders, EarlyView.
Abstract Background Although not confirmed, some studies have suggested that elevated homocysteine levels are common in patients with Huntington's disease (HD). Its clinical relevance remains unclear. Objectives We aimed to assess vitamin B and homocysteine levels in HD patients and explore the relationships among hyperhomocysteinemia, vitamin B ...
Salomé Puisieux, Elise Pourié, Céline Bonnet, Lucie Hopes, Solène Frismand, Myriam Bronner, Virginie Roth, Marion Wandzel, Natacha Sloboda, Laetitia Lambert, Abderrahim Oussalah, Amélia Julien, Irina Rotaru, Rosa‐Maria Guéant‐Rodriguez, Jean Louis Guéant, Carine Bossenmeyer‐Pourié, Mathilde Renaud   +16 more
wiley   +1 more source

Neuropsychological Sub-Phenotypes in Amyotrophic Lateral Sclerosis. [PDF]

Eur J Neurol
Poletti B, Aiello EN, Consonni M, Iazzolino B, Torre S, Faltracco V, Telesca A, Palumbo F, Curti B, De Luca G, Moreschi A, Frisco F, Bella ED, Bersano E, Riva N, Verde F, Messina S, Doretti A, Maranzano A, Morelli C, Cappa SF, Calvo A, Strong MJ, Silani V, Lauria G, Chiò A, Ticozzi N.   +26 more
europepmc   +1 more source

Real‐World Evaluation of Bilateral Magnetic Resonance–Guided Focused Ultrasound Thalamotomy in Essential Tremor

Movement Disorders, EarlyView.
Abstract Background Magnetic resonance–guided focused ultrasound (MRgFUS) thalamotomy is effective in treating essential tremor (ET) with an adequate safety profile. Objective The aim of the study was to evaluate the real‐world safety and efficacy of staged bilateral MRgFUS thalamotomy in ET and its impact on patient's quality of life (QoL) and patient‐
Dolores Vilas, Antonio Gonzalez, Manel Tardáguila, Lourdes Ispierto, Mireia Gea, José Antonio Pérez, Raquel García, Ramiro Álvarez, Jorge Muñoz   +8 more
wiley   +1 more source

Apathy in Lewy Body Disorders: A Position Paper

Movement Disorders, EarlyView.
Abstract Apathy is one of the most prevalent and disabling non‐motor symptoms in Parkinson's disease (PD) and dementia with Lewy bodies (DLB), collectively referred to as Lewy body disorders (LBDs). It is associated with reduced quality of life, accelerated cognitive decline, increased caregiver burden, and poorer functional outcomes, yet remains ...
Jaime Kulisevsky, Lidia Bojtos, Milica G. Kramberger, Elisa Mantovani, Iulia Murasan, Jose‐Alberto Palma, Karolina Poplawska‐Domaszewicz, Anna Sauerbier, Kallol Ray Chaudhuri, Per Odin, Daniel Weintraub, Anette Schrag, Cristian Falup‐Pecorariu   +12 more
wiley   +1 more source