Repolarization adaptation to rapid change in heart rate in human models – a review
The Journal of Physiology, EarlyView.Abstract figure legend This review focuses on non‐invasive assessment of repolarization duration and dispersion (heterogeneity) adaptation to change in heart rate (HR). HR was increased incrementally by left atrial pacing during an electrophysiology (EP) study and by a bolus injection of atropine and in a step up/down fashion by repeated right atrial ...
Lennart Bergfeldt +5 more
wiley +1 more source
A Three-Terminal Si-Ge Avalanche Photodiode with a Breakdown Voltage of 6.8 V and a Gain Bandwidth Product of 1377 GHz. [PDF]
Micromachines (Basel)Cheng C, Xue J, Yu X, Mu J, Wang B.
europepmc +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Small‐conductance calcium‐activated potassium (SK) channels are important for atrial repolarization and can be targeted for atrial‐specific antiarrhythmic treatments. We developed a computational model with a calcium sensor to study the effects of increased pacing rate (5 Hz), which enhances SK‐channel gating and forward ...
Stefan Meier +3 more
wiley +1 more source
Comparative effectiveness and safety of systemic therapies for treatment-naïve, PD-L1 expression <1% advanced NSCLC: a systematic review and network meta-analysis. [PDF]
Transl Lung Cancer ResZhou M +10 more
europepmc +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Schematic overview of the study's methodology and key findings. In a preclinical swine model, doxorubicin administration induced cardiotoxicity, characterized by diffuse fibrotic remodelling and altered electrical function, as assessed by magnetic resonance (MR) imaging and electrophysiological mapping.
Javier Villar‐Valero +7 more
wiley +1 more source
Economic evaluation of dialysis treatment in end-stage renal disease patients with fluid and sodium overload: Evidence from a randomized controlled trial in Thailand. [PDF]
PLoS OneYoungkong S +5 more
europepmc +1 more source
Deciphering pro‐arrhythmogenic mechanisms of EPAC in human atrial cardiomyocytes
The Journal of Physiology, EarlyView.Abstract figure legend This study aimed to investigate the effect of exchange proteins directly activated by cAMP (EPAC) on the regulation of human atrial cardiomyocyte electrophysiology and their potential involvement in the onset of atrial fibrillation (AF).
Arthur Boileve +11 more
wiley +1 more source
Performance of Children with and without Auditory Processing Disorders in Adaptive Temporal Gap Detection Measures. [PDF]
Int Arch OtorhinolaryngolJain C, Tanniru K, Kalarikkal G.
europepmc +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Modelling β‐adrenergic stimulation in sympathetically remodelled ventricular substrates. Myocardial infarction could result in sympathetic remodelling in ventricular tissues, which affects arrhythmia dynamics. However sympathetic remodelling is challenging to control experimentally; therefore we created an ionic model that ...
Kelly Zhang +3 more
wiley +1 more source