Results 71 to 80 of about 158,301 (286)

Relationship of Substance Use Disorder to Aggression in Male Subjects with Antisocial Personality Disorder [PDF]

Düşünen Adam Psikiyatri ve Nörolojik Bilimler Dergisi, 2007
Objective: Aggression is a particular problem commonly observed in personality disorders, especially in antisocial personality disorder (APD). It is well known that APD is closely related to substance use disorder (SUD).
Ayhan Algül, Ümit Başar Semiz, M. Alpay Ateş, Cengiz Başoğlu, Ali Doruk, Servet Ebrinç, Erdal Pan, Mesut Çetin   +7 more
doaj  

Pronounced effects of HERG-blockers E-4031 and erythromycin on APD, spatial APD dispersion and triangulation in transgenic long-QT type 1 rabbits. [PDF]

PLoS ONE, 2014
Prolongation of action potential duration (APD), increased spatial APD dispersion, and triangulation are major factors promoting drug-induced ventricular arrhythmia. Preclinical identification of HERG/IKr-blocking drugs and their pro-arrhythmic potential,
David Ziupa, Julia Beck, Gerlind Franke, Stefanie Perez Feliz, Maximilian Hartmann, Gideon Koren, Manfred Zehender, Christoph Bode, Michael Brunner, Katja E Odening   +9 more
doaj   +1 more source

Characterization of the Hamamatsu S8664 Avalanche Photodiode for X-Ray and VUV-light detection

, 2011
We present the first operation of the Avalanche Photodiode (APD) from Hamamatsu to xenon scintillation light and to direct X-rays of 22.1 keV and 5.9 keV. A large non-linear response was observed for the direct X-ray detection.
Aprile, Biagi, Bolotnikov, C. Martín, C.M.B. Monteiro, Chandrasekharan, Chandrasekharan, Coelho, E.D.C. Freitas, F. Sánchez, F.D. Amaro, Fernandes, Fernandes, G.V. Jover-Manas, Ikagawa, Ikagawa, J. Rico, Knoll, Lebedenko, Lopes, Ludhova, Lux, Monteiro, Monteiro, Moszynski, Moszynski, Neilson, Nygren, O. Ballester, Shagin, Sinclair, T. Lux   +31 more
core   +1 more source

Interactions of Antibody Drug Conjugate Anti‐Tubulin and Topoisomerase I Inhibitor Payloads with Radiotherapy to Potentiate Immunotherapy

Advanced Science, EarlyView.
Antibody drug conjugates deliver their cytotoxic anti‐tubulin or topoisomerase I inhibitor payloads to tumors through cancer cell receptor targeting. The released drug payloads induce cellular changes that interact with radiotherapy resulting in radiosensitization that improves cancer cell kill and stimulates anti‐tumor immune responses.
Jacqueline Lesperance, Bryan S. Yung, Michael M. Allevato, Marcus M Cheng, Maria F. Camargo, Robert Saddawi‐Konefka, Kanika Dhawan, Ashwyn K. Sharma, Mahsa Mortaja, Sophie Bice, Daniel J. Scanderbeg, Diego Alvarado, Jyoti Mayadev, Ramez N. Eskander, Stephen R. Adams, Pippa F. Cosper, J. Silvio Gutkind, Sunil J. Advani   +17 more
wiley   +1 more source

Calcium‐ and voltage‐driven atrial alternans: Insight from [Ca]i and Vm asynchrony

Physiological Reports, 2023
Cardiac alternans is defined as beat‐to‐beat alternations in contraction strength, action potential duration (APD), and Ca transient (CaT) amplitude. Cardiac excitation–contraction coupling relies on the activity of two bidirectionally coupled excitable ...
G. Kanaporis, E. Martinez‐Hernandez, L. A. Blatter   +2 more
doaj   +1 more source

A prototype ASIC for APD array readout of scintillating plastic fibers [PDF]

, 2002
We report on the development of custom front-end electronics for use with avalanche photodiode (APD) arrays as part of a NASA technology study for the readout of scintillating plastic fibers. APD arrays featuring 64 1 mm square pixels are used.
Cutlip, Hansford H, Frank, S Shane, Jagadish, U, Ledoux, J, Macri, John R, McConnell, Mark L, Widholm, Mark, Wintenerg, A L   +7 more
core   +1 more source

Experimental Determination of the Gain Distribution of an Avalanche Photodiode at Low Gains

, 2008
A measurement system for determining the gain distributions of avalanche photodiodes (APDs) in a low gain range is presented. The system is based on an ultralow-noise charge--sensitive amplifier and detects the output carriers from an APD.
Akiba, Makoto, Sasaki, Masahide, Tsujino, Kenji   +2 more
core   +1 more source

Regulating Tumor Metabolic Reprogramming with Biomimetic Co‐Delivery of Simvastatin and Kynureninase for Immunotherapy

Advanced Science, EarlyView.
After the intravenous injection of biomimetic and pH/ROS‐responsive PTSK@CRM, the nanoparticles can be accumulated in tumors and release Sim and KYNase to inhibit the tumor growth, regulate the metabolism of cholesterol and Kyn, and reverse the immunosuppressive tumor microenvironment.
Jiaxin Yin, Shengcai Yang, Zengguang Liu, Songchen Zhao, Siyu Sun, Ziling Liu, Quanshun Li   +6 more
wiley   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

A European perspective on auditory processing disorder-current knowledge and future research focus [PDF]

, 2017
Current notions of \u201chearing impairment,\u201d as reflected in clinical audiological practice, do not acknowledge the needs of individuals who have normal hearing pure tone sensitivity but who experience auditory processing difficulties in everyday ...
Bamiou, Doris-Eva, Barajas, Jose, Brechmann, Andr\ue3\ua9, Callimachou, Marina, Deggouj, Na\ue3\uafma, Demanez, Laurent, Grech, Helen, Hedjever, Mladen, Iliadou, Vasiliki, Kiese-Himmel, Christiane, Konukseven, Ozlem, Kuske, Sandra, Martins, Jorge Humberto, Mattsson, Tone Stokkereit, Nickisch, Andreas, Pedersen, Ellen Raben, Ptok, Martin, Santarelli, Rosamaria, Sirimanna, Tony, Sliwinska-Kowalska, Mariola, Thai-Van, Hung, Veraguth, Dorothy, Veuillet, Evelyne   +22 more
core   +7 more sources