Results 61 to 70 of about 49,952 (301)

Sequence‐Dependent Repolarization Is Modulated by Endogenous Action Potential Duration Gradients Rather Than Electrical Coupling in Ventricular Myocardium

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Previous studies suggest the relationship between activation time (AT) and action potential duration (APD) in the heart is dependent on electrotonic coupling, but this has not been directly tested.
Grace A. Blair, Madeline Depman, William P. Adams, Rowan O. Maisonneuve, Gregory S. Hoeker, Seth H. Weinberg, Steve Poelzing   +6 more
doaj   +1 more source

KEPATUHAN PENGGUNAAN ALAT PELINDUNG DIRI (APD) DI LABORATORIUM PADA MAHASISWA PRODI DIPLOMA ANALIS KESEHATAN UNIVERSITAS MH THAMRIN

Jurnal Ilmiah Kesehatan, 2019
Setiap pekerjaan memiliki risiko atau berpotensi mengalami kecelakaan kerja. Beberapa penyebab kecelakaan di laboratorium dapat bersumber dari sikap dan tingkah laku para pekerja, keadaan ang tida aman dan kurangnya pengawasan. Penelitian ini bertujuan
Catu Umirestu Nurdiani, Tri Krianto
doaj   +1 more source

ROS Self‐Supply Nanoplatform Based on Fenton Catalyst for Chemodynamic and Immunotherapy: Reprogramming Cold Tumor Into Hot Tumor in Cancer Treatment

Advanced Science, EarlyView.
A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee, Jack Chun Hin Chen, Wai Wing Cheng, Kwan Yee Lau, Hiu Yee Kwan, Ngar‐Yun Ellen Poon, Hung‐Wing Li   +6 more
wiley   +1 more source

A Glucose Metabolism‐Modulatory Nanobiohybrid Vaccine Platform Promotes Anti‐Tumor Immunity by Orchestrating Autophagy‐Dependent Cross‐Presentation and H2S‐Enhanced NLRP3 Inflammasome Signaling

Advanced Science, EarlyView.
A nanobiohybrid vaccine was designed by constructing a hydrogen‐bonded organic framework coencapsulated with glucose oxidase (GOx) and tumor antigens. This nanobiohybrid vaccine executed a GOx‐catalyzed enzyme reaction that disrupted glucose metabolism and induced redox imbalance in dendritic cells, leading to autophagy‐dependent antigen cross ...
Weidong Wang, Yimin Gong, Jianing Li, Tianze Wu, Mingli Deng, Yannan Yang   +5 more
wiley   +1 more source

Subgroups among APD children

, 2023
Auditory Processing Disorder (APD) is suspected to consist of several subgroups. In this analysis we use principal component analysis to investigate this in a Danish dataset containing both APD and control children. The analysis shows two separate groups
Ørebro, Trine Møller, Winther, Celina Gammelgaard, Brandt, Christian; id_orcid   +2 more
core   +1 more source

APD.

, 2015
A. Representative action potential traces and APD maps at pacing cycle lengths of 1000 ms and 500 ms. B. Mean APD80 at pacing cycle lengths of 1000 ms and 500 ms.
Hui-Ling Lee (174038), Po-Cheng Chang (438891), Shien-Fong Lin (438894), San-Jou Yeh (319239), Chung-Chuan Chou (600857), Hung-Ta Wo (600855), Ming-Shien Wen (319221), Yen Chu (290626)   +7 more
core   +1 more source

Rewiring Pyroptosis to Potentiate Cancer Immunotherapy via a Gasdermin D Agonist Bypassing Caspase‐3

Advanced Science, EarlyView.
This work introduces a small‐molecule agonist, DIBDO, that bypasses Casp‐3 to directly trigger GSDMD‐mediated pyroptosis in tumors. Activated by glutathione, DIBDO generates singlet oxygen and molecular iodine, blocking Casp‐3 pathways and inducing immunogenic cell death.
Dan Zhao, Lingling Zhang, Yue Wen, Lianghui Cheng, Sidan Tian, Fanling Meng, Liang Luo   +6 more
wiley   +1 more source

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, EarlyView.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source

Cancer‐Associated BCL‐2 Mutants Reveal Mechanisms Towards Venetoclax Resistance

Advanced Science, EarlyView.
Venetoclax (VEN) resistance in chronic lymphocytic leukemia arises from diverse BCL2 mutations. We map mechanisms contributing to VEN resistance across common BCL‐2 variants. G101V and D103Y reduce drug binding and increase sequestration of pro‐apoptotic proteins. V156D blocks VEN allosterically.
Jonas Aufdermauer, Ian de Ridder, Mahjoobeh Ehsani, Marasim Khan, Justin Kale, Lukas P. Frenzel, David Andrews, Spyridoula Karamanou, Ana J. Garcia‐Saez, Geert Bultynck   +9 more
wiley   +1 more source

Employee Entrepreneurial Skills and Performance of APD Construction Nigeria Limited Abuja

The way for good performance is a strong culture. It is the collective programming of the mind which distinguishes the members of an organization from another.There is no empirical research conducted on the effect of organizational culture on ...
Ikupolati, A.O., Olaleye, Y.O., Adelodun, S.S., Faruna, D.O   +3 more
core   +3 more sources