Results 121 to 130 of about 23,711 (313)

Apelin enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells partly through Wnt/β-catenin signaling pathway

Stem Cell Research & Therapy, 2019
Background Management of fracture healing with a large bone defect remains a tricky subject in orthopedic trauma. Enhancing osteogenesis of human bone marrow-derived mesenchymal stem cells (hBMSCs) is one of the useful therapeutic strategies for fracture
Kai Hang, Chenyi Ye, Jianxiang Xu, Erman Chen, Cong Wang, Wei Zhang, Lic Ni, Zhih Kuang, Li Ying, Deting Xue, Zhijun Pan   +10 more
doaj   +1 more source

Aryl Hydrocarbon Receptor in Health and Disease

MedComm, Volume 6, Issue 11, November 2025.
Based on the structure and ligands of AhR, this review introduces the AhR‐related signaling pathways and their roles in health and diseases. Agonists and antagonists of AhR as well as new strategies for treatment using the microbial–AhR axis are summarized. A prospect was made for the future use of AhR as a therapeutic target.
Haonan Li, Yufeng Fan, Jizheng Liu, Shumin Dong, Bin Wen, Yunfei Zhang, Xiaocui Wang, Xuemei Duan, Ying Hu, Ze Yan, Huifeng Shang, Yukai Jing   +11 more
wiley   +1 more source

Altered glucose homeostasis is associated with increased serum apelin levels in type 2 diabetes mellitus.

PLoS ONE, 2012
BackgroundApelin is an adipokine that plays a role in the regulation of glucose homeostasis and in obesity. The relationship between apelin serum concentration and dysmetabolic conditions such as type 2 diabetes (T2D) is still controversial.
Maria Gisella Cavallo, Federica Sentinelli, Ilaria Barchetta, Carmine Costantino, Michela Incani, Laura Perra, Danila Capoccia, Stefano Romeo, Efisio Cossu, Frida Leonetti, Luciano Agati, Marco G Baroni   +11 more
doaj   +1 more source

The Protective Effects and Mechanisms of Apelin/APJ System on Ischemic Stroke: A Promising Therapeutic Target

Frontiers in Neurology, 2020
The orphan receptor APJ and its endogenous ligand apelin, which are expressed in the brain, are the major components of the apelin/APJ system. Growing evidence shows that the apelin/APJ system plays a vital role in the pathophysiology of cerebral ...
Yanjun Tian, Ruijiao Chen, Yunlu Jiang, Yunlu Jiang, Bo Bai, Tongju Yang, Haiqing Liu   +6 more
doaj   +1 more source

Hypoglycemia Induces Diabetic Macrovascular Endothelial Dysfunction via Endothelial Cell PANoptosis, Macrophage Polarization, and VSMC Fibrosis

Advanced Science, Volume 12, Issue 37, October 6, 2025.
This study investigates hypoglycemia‐induced diabetic macrovascular endothelial dysfunction. It reveals that hypoglycemia triggers ZBP1‐dependent PANoptosis of endothelial cells, proinflammatory polarization of macrophages, and fibrosis of vascular smooth muscle cells (VSMCs) in diabetic mice.
Deyu Zuo, Yuce Peng, Guozhi Zhao, Zhesheng Cheng, Minghao Luo, Dingyi Lv, Shuting Chang, Na Li, Yanyao Huang, Xunjia Li, An He   +10 more
wiley   +1 more source

MicroRNA-483 amelioration of experimental pulmonary hypertension. [PDF]

, 2020
Endothelial dysfunction is critically involved in the pathogenesis of pulmonary arterial hypertension (PAH) and that exogenously administered microRNA may be of therapeutic benefit.
Bai, Liang, Chen, Shanshan, Chou, Chih-Hung, Cui, Xiaopei, Fan, Fenling, Gongol, Brendan, Gu, Mingxia, He, Ming, He, Yangyang, Huang, Hsien-Da, Jing, Zhi-Cheng, Lei, Yuyang, Li, Zhao, Malhotra, Atul, Miao, Yifei, Rabinovitch, Marlene, Shen, Yuan, Shyy, John Y-J, Wang, Xiaojian, Yan, Xiaosong, Zhang, Jiao, Zhang, Jin, Zhang, Yixin   +22 more
core   +1 more source

Effects of Apelin on the fibrosis of retinal tissues and Müller cells in diabetes retinopathy through the JAK2/STAT3 signalling pathway

Autoimmunity, 2023
Retinal fibrosis was a key characteristic of diabetes retinopathy (DR). Apelin was found to be a candidate for tissue fibrosis. Nevertheless, the role of Apelin in the Müller cells in DR remains unclear.
Yang Li, Qinrui Hu, Bin Wang
doaj   +1 more source

Mitochondrial Microproteins: Emerging Regulators in Neurodevelopment and Neurodegeneration

BioEssays, Volume 47, Issue 10, October 2025.
Mitochondrial microproteins have emerged as critical regulators of mitochondrial function. Neurons are highly dependent on mitochondria to sustain their function. Mitochondrial microproteins can be deregulated and can contribute to the pathogenesis of neurodegenerative disorders. Mitochondrial microproteins are involved in neuronal development. However,
Nada Borghol, Sozerko Yandiev, Julien Courchet   +2 more
wiley   +1 more source

304Nuclear targeting apelin induces phenotypic transition of vascular smooth muscle cells [PDF]

, 2017
Background: Apelin, and its receptor APJ, are a peptidic system playing a crucial role in vascular diseases. However, the role of apelin in atherogenesis and smooth muscle cell (SMC) proliferation remains unclear.
Audigier, Y., Baertschi, AJ, Bochaton-Piallat, ML, Brun, C., Chaabane, C., Konig, S., Roatti, A.   +6 more
core  

Individual and Comorbid Influences of Chronic Stress and a Western Diet on Allostatic Loads and Cardiac Resilience, Adaptation and Proteome Profiles in Male Mice

Comprehensive Physiology, Volume 15, Issue 5, October 2025.
These findings support positive interactions between common risk factors in comorbid development of cardiovascular and affective disorders. Mitochondrial and innate defense paths may contribute to the influences of diet, stress, and preconditioning.
Makayla Nicholas, Tessa Helman, Brock Lyon, Saba Naghipour, Trissha Ybanez, Joshua T. Ingles, Chulkyu Kim, Nicolas J. C. Stapelberg, Jason N. Peart, John P. Headrick, Eugene F. du Toit   +10 more
wiley   +1 more source