Results 131 to 140 of about 23,711 (313)

Apelin increases cardiac contractility via protein kinase Cε- and extracellular signal-regulated kinase-dependent mechanisms.

PLoS ONE, 2014
BackgroundApelin, the endogenous ligand for the G protein-coupled apelin receptor, is an important regulator of the cardiovascular homoeostasis.
Ábel Perjés, Réka Skoumal, Olli Tenhunen, Attila Kónyi, Mihály Simon, Iván G Horváth, Risto Kerkelä, Heikki Ruskoaho, István Szokodi   +8 more
doaj   +1 more source

High‐Calorie Diet During Pregnancy Leads to Muscular Fibrosis and Neuromuscular Damage in Offspring Mice

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 5, October 2025.
ABSTRACT Background Sarcopenia, recognized as an age‐related loss of muscle mass and function, is a critical risk for geriatric health. We previously demonstrated that maternal high‐fat diet (HFD) suppresses mitochondrial biogenesis during fetal skeletal muscle development, but the longitudinal effect of maternal HFD challenge on offspring muscle ...
Jun Seok Son, Song Ah Chae, Yoon Ha Chun, Hongyang Wang, Zhihua Jiang, Min Du   +5 more
wiley   +1 more source

Az angiogén faktorok szerepe praeeclampsiában [PDF]

, 2014
Preeclampsia is one of the most common and most serious complications of pregnancy and the management of this condition still challenges obstetricians. Despite intensive research the etiology of preeclampsia still remains unclear. At the beginning of the
Alasztics, Bálint, Gullai, Nóra, Molvarec, Attila, Rigó, János   +3 more
core   +1 more source

The Role of Apelin in the Functioning of the Reproductive System

Acta Biomedica Scientifica, 2019
Adipokine apelin through the apelin receptors activates a wide range of signaling cascades in the target cells and controls their growth, differentiation, apoptosis, and energy metabolism.
A. O. Shpakov, K. V. Derkach
doaj   +1 more source

Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer’s Disease Through Activation of BDNF-TrkB Signaling Pathway

Frontiers in Pharmacology, 2019
Alzheimer’s disease (AD), a progressive neurodegenerative disease characterized by impairments of cognitive function as a result of synaptic deficits and neuronal loss, is associated with inflammation.
Huaiqing Luo, Y. Xiang, X. Qu, Hui-jun Liu, Chi Liu, Guang-yi Li, Liping Han, X. Qin   +7 more
semanticscholar   +1 more source

Integrated Multi‐Omics Analysis and Cross‐Model Validation Reveal Mitochondrial Signatures in Alzheimer's Disease

CNS Neuroscience &Therapeutics, Volume 31, Issue 10, October 2025.
This study's framework begins with large‐scale data integration, leveraging the ROSMAP cohort for multi‐omics discovery (genotyping, DNA methylation, transcriptomics, miRNA) and the ADNI cohort for validation. This data feeds into a comprehensive analytical pipeline where differential expression analysis and an ensemble of 10 machine learning ...
Xuan Xu, Sha‐Sha Fan, Jiang Li, Hao Wu, Junwen He, Yang He, Xiang‐Yu Meng, Yin Shen   +7 more
wiley   +1 more source

Az apelin/APJ receptor rendszer szerepe humán endotheliális progenitor sejtekben = Role of the apelin/angiotensin receptor-like 1 receptor system in human endothelial progenitor cells [PDF]

, 2010
Az angiotenzin receptor-szerű 1 (APJ) receptor és endogén ligandja, az apelin szerepet játszanak a szív és érrendszeri betegségek kifejlődésében. Klinikai és állatkísérletes vizsgálataink során kimutattuk, hogy apelin és APJ expressziók alacsonyabbak ...
Földes, Gábor
core  

Neuroprotective effect of Apelin 13 on ischemic stroke by activating AMPK/GSK-3β/Nrf2 signaling

Journal of Neuroinflammation, 2019
Previous studies had showed that Apelin 13 could protect against apoptosis induced by ischemic/reperfusion (I/R). However, the mechanisms whereby Apelin 13 protected brain I/R remained to be elucidated. The present study was designed to determine whether
Jialin Duan, J. Cui, Zhifu Yang, Chao Guo, Jinyi Cao, Miaomiao Xi, Y. Weng, Ying Yin, Yanhua Wang, G. Wei, Boling Qiao, A. Wen   +11 more
semanticscholar   +1 more source

Metabolic and Inflammatory Stimuli Impact Vascular Circulation and Cell Proliferation Processes in the Amygdala

Genes, Brain and Behavior, Volume 24, Issue 5, October 2025.
Sex‐specific differential expression of the genes in the synaptic vesicle cycle pathway of the amygdala in response to stimuli. In the pathway network depiction, the edges connecting the nodes (genes) represent known molecular interactions. More intense red and blue hues indicate gene under‐expression and over‐expression in response to fasting relative
Sreelaya Bhamidi, Gloria R. Sunderland, Bruce R. Southey, Maria B. Villamil, Rodney W. Johnson, Sandra L. Rodriguez‐Zas   +5 more
wiley   +1 more source

Immunocytochemical localisation of the apelin receptor, APJ, to human cardiomyocytes, vascular smooth muscle and endothelial cells [PDF]

, 2004
Matthias J. Kleinz, Jeremy N. Skepper, Anthony P. Davenport   +2 more
openalex   +2 more sources