Results 141 to 150 of about 23,711 (313)

RUNX3-activated apelin signaling inhibits cell proliferation and fibrosis in diabetic nephropathy by regulation of the SIRT1/FOXO pathway

Diabetology & Metabolic Syndrome
Background Diabetic nephropathy is a major secondary cause of end-stage renal disease. Apelin plays an important role in the development of DN. Understanding the exact mechanism of Apelin can help expand the means of treating DN.
Xin Zhong, Jun Zhang
doaj   +1 more source

Apelin-13 enhances arcuate POMC neuron activity via inhibiting M-current.

PLoS ONE, 2015
The hypothalamus is a key element of the neural circuits that control energy homeostasis. Specific neuronal populations within the hypothalamus are sensitive to a variety of homeostatic indicators such as circulating nutrient levels and hormones that ...
Dong Kun Lee, Jae Hoon Jeong, Seunghoon Oh, Young-Hwan Jo   +3 more
doaj   +1 more source

The Role of the Apelin/APJ System in the Regulation of Liver Disease

Frontiers in Pharmacology, 2017
Apelin is an endogenous peptide that is a ligand for the APJ receptor (angiotensin II receptor like-1, AT-1). The apelin/APJ system is distributed in diverse periphery organ tissues.
Wei-Dong Chen, Wei-Dong Chen, Yan-Dong Wang, Xinrui Lv, Jing Kong   +4 more
doaj   +1 more source

Apelin ameliorates sepsis-induced myocardial dysfunction via inhibition of NLRP3-mediated pyroptosis of cardiomyocytes

Heliyon
Sepsis-induced myocardial dysfunction (SMD) is the major cause of death in sepsis. Nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3)-mediated pyroptosis contributes to the occurrence and development of SMD ...
Zhi Cao, Weifeng Li, Zhuang Shao, Xinqiang Liu, Yi Zeng, Peijun Lin, Chuangqiang Lin, Yuechu Zhao, Ting Li, Zichao Zhao, Xin Li, Yuelin Zhang, Bei Hu   +12 more
doaj   +1 more source

Apelin protects against NMDA-induced retinal neuronal death via an APJ receptor by activating Akt and ERK1/2, and suppressing TNF-α expression in mice

Journal of Pharmacological Sciences, 2017
Glutamate excitotoxicity mediated by N-methyl-d-aspartate (NMDA) receptors is an important cause of retinal ganglion cell death in glaucoma. To elucidate whether apelin protects against retinal neuronal cell death, we examined protective effects of ...
Yuki Ishimaru, Akihide Sumino, Daiki Kajioka, Fumiya Shibagaki, Akiko Yamamuro, Yasuhiro Yoshioka, Sadaaki Maeda   +6 more
doaj   +1 more source

Apelin-additional marker of insulin resistance [PDF]

, 2015
The purpose of the present study was to determine the correlations between the state of carbohydrate metabolism and concentrations of apelin in blood of patients with type 2 diabetes mellitus with different ...
Shekhovtsova, Y. A., Zhuravlyova, L. V.
core   +1 more source

Phenotypic and functional characterization of corneal endothelial cells during in vitro expansion. [PDF]

, 2020
The advent of cell culture-based methods for the establishment and expansion of human corneal endothelial cells (CEnC) has provided a source of transplantable corneal endothelium, with a significant potential to challenge the one donor-one recipient ...
Aldave, Anthony J, Azimov, Rustam, Boere, Payton M, Chung, Doug D, Frausto, Ricardo F, George, Benjamin L, Hanser, E Maryam, Kao, Liyo, Kurtz, Ira, Mehta, Jodhbir S, Morselli, Marco, Peh, Gary SL, Pellegrini, Matteo, Swamy, Vinay S, Wu, Jessica   +14 more
core  

The impact of apelin-36 on isolated rat hearts as a member of apelin family

Bratislava Medical Journal, 2018
Apelin is an endogenous adipocytokine that plays an important role in the regulation of cardiovascular function. Apelin-36 is a member of apelin family. However cardiac reports related to apelin-36 are very rare. The purpose of this study is to investigate the impact of apelin-36 on hemodynamic variables of the isolated rat hearts.Twenty-eight rats ...
openaire   +4 more sources

Structure–function relationship and physiological role of apelin and its G protein coupled receptor

Biophysical Reviews, 2023
Subhashree Murali, G. K. Aradhyam
semanticscholar   +1 more source

Comparison of serum apelin levels and maximal oxygen consumption in active and inactive obese men [PDF]

, 2018
Backgrounds: Apelin is an adipokine that may play a significant role in regulating energy metabolism. Obesity and physical activity are factors that affect the concentration of apelin, but it is not known which one is more prominent.
Abasi, Salar, Nikseresht, Mahmoud
core