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Peptides, 2022
The apelin/apelin receptor (ApelinR) signal transduction pathway exerts essential biological roles, particularly in the cardiovascular system. Disturbances in the apelin/ApelinR axis are linked to vascular, heart, kidney, and metabolic disorders. Therefore, the apelinergic system has surfaced as a critical therapeutic strategy for cardiovascular ...
Amanda A. de Oliveira +4 more
openaire +2 more sources
The apelin/apelin receptor (ApelinR) signal transduction pathway exerts essential biological roles, particularly in the cardiovascular system. Disturbances in the apelin/ApelinR axis are linked to vascular, heart, kidney, and metabolic disorders. Therefore, the apelinergic system has surfaced as a critical therapeutic strategy for cardiovascular ...
Amanda A. de Oliveira +4 more
openaire +2 more sources
Journal of Cellular Physiology, 2022
Cardiac hypertrophy is a leading cause of cardiac morbidity and mortality worldwide. Apelin is the endogenous ligand for the G protein‐coupled receptor, APJ.
Yiyuan Yang +7 more
semanticscholar +1 more source
Cardiac hypertrophy is a leading cause of cardiac morbidity and mortality worldwide. Apelin is the endogenous ligand for the G protein‐coupled receptor, APJ.
Yiyuan Yang +7 more
semanticscholar +1 more source
Clinica Chimica Acta, 2018
Apelin, a regulatory peptide, is a ligand of the APJ receptor that belongs to the G protein-coupled receptor family. Apelin and APJ are widely distributed in the body and play potential physiological roles in the cytoprotection of many internal organs.
Hanna Antushevich, Maciej Wójcik
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Apelin, a regulatory peptide, is a ligand of the APJ receptor that belongs to the G protein-coupled receptor family. Apelin and APJ are widely distributed in the body and play potential physiological roles in the cytoprotection of many internal organs.
Hanna Antushevich, Maciej Wójcik
openaire +3 more sources
American Journal of Physiology - Cell Physiology
Plasma apelin levels are reduced in aging and muscle wasting conditions. We aimed to investigate the significance of apelin signaling in cardiac and skeletal muscle responses to physiological stress.
Teemu Kilpiö +10 more
semanticscholar +1 more source
Plasma apelin levels are reduced in aging and muscle wasting conditions. We aimed to investigate the significance of apelin signaling in cardiac and skeletal muscle responses to physiological stress.
Teemu Kilpiö +10 more
semanticscholar +1 more source
2016
Over the past decades, obesity became a tremendous socioecological problem, reaching epidemic dimensions and the number of accompanying comorbidities including type 2 diabetes and cardiovascular diseases can be extended by different types of cancer.
Roland E. Kälin, Stefanie Kälin
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Over the past decades, obesity became a tremendous socioecological problem, reaching epidemic dimensions and the number of accompanying comorbidities including type 2 diabetes and cardiovascular diseases can be extended by different types of cancer.
Roland E. Kälin, Stefanie Kälin
openaire +2 more sources
Apelin levels in normal pregnancy
Clinical Endocrinology, 2011Apelin is an adipokine secreted from adipose and other tissues with increased expression in obesity, role in glucose metabolism and atherosclerosis, as well as in oxidative stress. Pregnancy is considered a state of hyperlipidemia, oxidative stress and decreased insulin sensitivity. The aim of the present study is to investigate the levels of apelin in
Konstantinos A Toulis +8 more
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Apelin/Apelin receptor: A new therapeutic target in Polycystic Ovary Syndrome
Life Sciences, 2020Polycystic ovary syndrome (PCOS) is an endocrinopathy, and it accounts for 75% of non-ovulatory infertile in women of childbearing age. It is clear that obesity, insulin resistance, dyslipidaemia coexist in PCOS. Apelin, as an endogenous ligand of the previously orphan receptor, is an adipokine that secreted by adipose tissue.
Qi Liu +5 more
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Evaluation of serum apelin‐13 and apelin‐36 concentrations in preeclamptic pregnancies
Journal of Obstetrics and Gynaecology Research, 2019AbstractAimRecent studies suggest that apelin can be a novel potential therapeutic mediator to improve the diagnosis, and treatment of preeclampsia. This study aimed to investigate the association of serum apelin‐13 and apelin‐36 with preeclampsia and to detect their relationship with preeclampsia‐associated perinatal morbidity.MethodsForty‐four women ...
Beril Gürlek +6 more
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2016
Apelin was isolated and characterized as an endogenous ligand for a G protein-coupled receptor, APJ. Human apelin gene encodes a pre-proprotein of 77 aa residues. After cleavage of the signal peptide, the proprotein of 55 aa residues generates several active fragments, including apelin 36, apelin 17, and apelin 13.
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Apelin was isolated and characterized as an endogenous ligand for a G protein-coupled receptor, APJ. Human apelin gene encodes a pre-proprotein of 77 aa residues. After cleavage of the signal peptide, the proprotein of 55 aa residues generates several active fragments, including apelin 36, apelin 17, and apelin 13.
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Pyroglutamyl apelin-13 identified as the major apelin isoform in human plasma
Analytical Biochemistry, 2013Apelin is emerging as an important hormone regulator of cardiovascular homoeostasis and an important biomarker for heart failure. Apelin concentrations have historically been measured by immunoassays; however, reported apelin concentrations measured in healthy volunteers show a large disparity from a few picograms per milliliter (pg/ml) to several ...
Richard E. Higgs +2 more
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