Results 281 to 290 of about 23,711 (313)

New structural insights into the apelin receptor: identification of key residues for apelin binding

The FASEB Journal, 2014
Apelin is the endogenous ligand of the orphan 7-transmembrane domain GPCR APJ, now named the apelin receptor (ApelinR). Apelin plays a prominent role in body fluid and cardiovascular homeostasis. To better understand the structural organization of the ApelinR, we built 3 homology 3-dimensional (3D) models of the human ApelinR using the validated ...
Gerbier, Romain, Leroux, Vincent, Couvineau, Pierre, Alvear-Perez, Rodrigo, Maigret, Bernard, Llorens-Cortes, Catherine, Iturrioz, Xavier   +6 more
openaire   +4 more sources

Neuroprotective Roles of Apelin-13 in Neurological Diseases

Neurochemical Research, 2023
Yang Zhang, Weiwei Jiang, Wenjie Sun, Weiming Guo, Beibei Xia, Xiangru Shen, Mingyuan Fu, Teng Wan, Mei Yuan   +8 more
semanticscholar   +1 more source

Neuroprotective effect of apelin-13 and other apelin forms—a review

Pharmacological Reports
Neurodegenerative diseases, which occur when neurons begin to deteriorate, affect millions of people worldwide. These age-related disorders are becoming more common partly because the elderly population has increased in recent years. While no treatments are accessible, every year an increasing number of therapeutic and supportive options become ...
Katarzyna Kamińska, Hubert Borzuta, Kasper Buczma, Agnieszka Cudnoch-Jędrzejewska   +3 more
openaire   +2 more sources

Apelin-13 protects against cisplatin-induced ototoxicity by inhibiting apoptosis and regulating STAT1 and STAT3

Archives of Toxicology, 2023
Haiyan Yin, Yinuo Sun, Bailiu Ya, Yan‐jun Guo, Hao Zhao, Lili Zhang, Fan Wang, Weiwei Zhang, Qianqian Yang   +8 more
semanticscholar   +1 more source

The Role of Apelins in the Physiology of the Heart

Protein & Peptide Letters, 2013
Apelins are a peptide hormone known as the ligand for the G protein-coupled APJ receptor. There are many different forms of apelin in the circulation. Apelins and their receptors are expressed in the central nervous system, including the hypothalamus, and in numerous other peripheral tissues. These peptides are also synthesized in and secreted from the
Mehmet Nesimi Eren, Suleyman Aydin, Suna Aydin, İbrahim Sahin   +3 more
openaire   +3 more sources

Apelin

2013
Heikki Ruskoaho, István Szokodi, Klára Farkasfalvi, Ábel Perjés   +3 more
  +9 more sources

Apelin/APJ system and cancer

Clinica Chimica Acta, 2016
Apelin is an endogenous ligand of the apelin receptor (APJ), a seven-transmembrane G protein-coupled receptor. Apelin/APJ system has a wide tissue distribution in the brain as well as in peripheral organs including heart, lung, vessels, and adipose tissue.
Ye Wenling, Shuangyu Lv, Liang Zhang, Yanjie Yang   +3 more
openaire   +3 more sources

Apelin cells in the rat stomach

Regulatory Peptides, 2005
Apelin is a recently discovered peptide that is the endogenous ligand for the APJ receptor. Apelin is produced in the central nervous system, heart, lung, mammary gland and gastrointestinal (GI) tract. The aim of this study was to identify by immunohistochemistry (IHC) cell types in the rat stomach that produce apelin peptide.
Hui Quin Wang, Ella W. Englander, George H. Greeley, Gan Cao, Guiyun Wang, Etsuko Susaki   +5 more
openaire   +3 more sources

Structural insight into apelin receptor-G protein stoichiometry

Nature Structural & Molecular Biology, 2022
Y. Yue, Lier Liu, Lijie Wu, Yiran Wu, Lingling Wang, Fei Li, Junlin Liu, G. Han, Bo Chen, Xi Lin, R. Brouillette, Émile Breault, Jean-Michel Longpré, S. Shi, Hui Lei, P. Sarret, R. Stevens, M. Hanson, Fei Xu   +18 more
semanticscholar   +1 more source

Apelin/APJ system in inflammation.

International Immunopharmacology, 2022
Xu Wang, Lu Zhang, Peisen Li, Yafei Zheng, Yanjie Yang, Shaoping Ji   +5 more
semanticscholar   +1 more source