Results 151 to 160 of about 381,033 (292)

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source

Suicide-Related Responses From AI Chatbots Through Application Programming Interfaces and Consumer-Facing Apps: Observational Cross-Sectional Comparative Study. [PDF]

J Med Internet Res
Cantor J, Huang E, Zhang LA, Salas A, Zhang F, Burnett A, Lohn A, Pataranutaporn P, Rader B, Yu H, McBain RK.   +10 more
europepmc   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

ИССЛЕДОВАНИЕ ФУНКЦИОНАЛА ПО УПРАВЛЕНИЮ СЕТЬЮ ПОСРЕДСТВОМ ПОДСИСТЕМЫ D-BUS В ОС АЛЬТ

Профессионалитет
В статье исследуются возможности управления сетевыми подключениями в операционной системе Альт с использованием универсальной системной шины D-Bus и сервиса NetworkManager.
В. Ю. Корякин, Э. В. Тищенко   +1 more
doaj  

Apigenin accelerates fracture healing by enhancing endochondral differentiation and inflammation resolution via targeting NF-κB signaling. [PDF]

Front Immunol
Shen H, Zhi G, Li Z, Yan X, Du Z, Zhang S, Yang R, Ma X, Liu H, Geng F, Li B.   +10 more
europepmc   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

In Vitro Comparison of Microenvironmental pH Modulation Approaches for Minzasolmin. [PDF]

Pharmaceutics
Stauffer F, Bouquelle A, Le Meur S, Segregur D, Laredj F, Ates C, Huygens C, Pilcer G.   +7 more
europepmc   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Interpretable Deep Supramolecular Language Modeling for Cocrystal Design: PCA-Augmented <i>DeepCocrystal</i> Screening of Picolinamide, Nicotinamide, and Isonicotinamide Systems. [PDF]

Molecules
Bozkurt B, Yilmaz A, Ogruc Ildiz G, Fausto R.   +3 more
europepmc   +1 more source