Results 161 to 170 of about 381,033 (292)

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

Critical Quality Attributes of Acyclovir Topical Creams: Characterization of Quality Attributes with Relevance to Topical Bioavailability. [PDF]

Pharm Res
Angamuthu M, Anegunda S, Rangappa S, Maurya A, Sm H, Kundu S, Maibach H, Ghosh P, Raney SG, Murthy SN.   +9 more
europepmc   +1 more source

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

Measurement of the Turbopause Level and Turbulent Velocity in the Lower Ionosphere Based on the Creation of Artificial Periodic Irregularities in the Ionospheric Plasma. [PDF]

Sensors (Basel)
Bakhmetieva NV, Zhemyakov IN, Kalinina EE.   +2 more
europepmc   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source

Regional micro-computed tomography analysis enables longitudinal detection of compensatory ventilation effects in a mouse model of pulmonary fibrosis. [PDF]

Am J Respir Cell Mol Biol
Buccardi M, Pennati F, Ferrini E, Buseghin D, Polverini E, Sverzellati N, Aliverti A, Stellari FF.   +7 more
europepmc   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Arterial Pulsatility Index in Acute Myocardial Infarction-Related Cardiogenic Shock: Clinical Characteristics and Association With Outcomes. [PDF]

J Am Heart Assoc
Sundermeyer J, Li S, Ton VK, Kataria R, Zweck E, Garan AR, Kanwar MK, Hernandez-Montfort J, Sinha SS, Abraham J, John KJ, Sangal P, Mahr C, Natov PS, Aslam MI, Burkhoff D, CSWG Academic Research Consortium, Kapur NK.   +17 more
europepmc   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

A novel framework for quantifying the clinical impact of substandard and falsified antimicrobials: Application to typhoid fever. [PDF]

PLOS Glob Public Health
Cavany S, Adipo L, van Assche K, Caillet C, Dolecek C, Hauk C, Mendes J, Nanyonga S, Stoesser N, Newton PN, Parry CM, Cooper BS.   +11 more
europepmc   +1 more source