Results 181 to 190 of about 116,267 (267)

Machine Learning-Driven Techno-Economic Uncertainty Analysis in Batch Pharmaceutical Manufacturing. [PDF]

ACS Omega
Ordonez DAR, Costa da Silva Mesquita L, Brandão ALT.   +2 more
europepmc   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Pharmaceutical Pollutants in Urban Rats Are Linked to Zoonotic Infection Risk. [PDF]

Environ Sci Technol Lett
Sundberg AJ, Cerveny D, Costa F, Begon M, Souza FN, Cruz JS, Zeppelini CG, Argibay HD, de Oliveira Carneiro I, Ko AI, Reis MG, McCallum ES, Khalil H.   +12 more
europepmc   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Placement-Dependent Accuracy of a Smartphone-Based Sensor Application Compared to an Accelerometer-Based System for Measuring Physical Activity in Healthy Adults: A Validation Study. [PDF]

Sensors (Basel)
Garval M, Pedersen L, Pedersen LM, Nielsen AKWDJ, Christiansen DH, Lange J, Wagner S.   +6 more
europepmc   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Accounting for Differences in Plasma Protein Binding between Fish and Humans for Supporting Environmental Risk Assessment of Pharmaceuticals Using the Fish Plasma Model. [PDF]

Environ Sci Technol
Brown AR, Trznadel M, Pedersen S, Nimrod Perkins A, Lee M, Mohutsky M, Bell A, Pihlaja TL, Sikanen T, Weil M, Coors A, Wilson RW, Tyler CR.   +12 more
europepmc   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Epidemiological patterns and healthcare utilization among malaria patients in Sorong City, Papua, Indonesia: A cross-sectional analysis of national surveillance data. [PDF]

PLoS One
Susilawati TN, Susanto H, Pham OKN, Kondororik F, Dewi VNL, Ahmar H, Putri NR, Lee R, Duong MC.   +8 more
europepmc   +1 more source