Results 191 to 200 of about 116,267 (267)

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Rethink context engineering using an attention-based architecture. [PDF]

Sci Rep
Yin Y.
europepmc   +1 more source

The crystal structure of the Borrelia burgdorferi nicotinamidase BBE22 resolves a long‐standing annotation error

FEBS Open Bio, EarlyView.
The crystal structure of Borrelia burgdorferi nicotinamidase (PncA/BBE22) reveals the correct full‐length protein initiated from a non‐canonical AUU start codon. The structure validates previous biochemical findings and resolves a long‐standing annotation error, demonstrating that the truncated database sequence is structurally incompatible with the ...
Kalvis Brangulis
wiley   +1 more source

Hot-melt extruded ibuprofen ternary solid dispersions using in-line UV-Vis: Impact of an ionizable polymer on thermodynamics and dissolution. [PDF]

Int J Pharm X
de Castro M, Almeida M, Luebbert C, Madu SJ, Khurana J, Evans M, Leivers M, Araujo G, Li M, Schlindwein W.   +9 more
europepmc   +1 more source

API documentation & API basecode

API documentation & API ...
openaire   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Explainable AI in Pharmaceutics: Grad-CAM Analysis of Surface Dissolution Imaging Using Convolutional Neural Networks. [PDF]

Pharmaceutics
Al-Baghdadi A, Pacławski A, Szlęk J, Mendyk A.   +3 more
europepmc   +1 more source

MaaS4EU API of APIs - Final Version

Final implementation and demonstration of Maas4EU API of APIs, integrating the data sources and services of transport and travel service providers available to the project. Report on unified MaaS travel ontology covering urban transport modes.
openaire   +1 more source

Small RNA pathways in mammalian oocytes

FEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

WiNGS-API: a federated genome/phenome data sharing platform enabling gene discovery and variant classification for rare diseases. [PDF]

Genome Med
Sattanathan N, Huremagic B, Vermeesch JR, Moreau Y, Vandeweyer G.   +4 more
europepmc   +1 more source