Results 31 to 40 of about 117,184 (267)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Malware detection based on visualization of recombined API instruction sequence

open access: yesConnection Science, 2022
This paper introduces a malware detection method based on the reorganisation of API instruction sequence and image representation in an effort to address the challenges posed by current methods of malware detection in terms of feature extraction and ...
Hongyu Yang   +3 more
doaj   +1 more source

auto{API} – A Web-Based Tool for Specification of an API Endpoint to Return JSON Data From an XML Source

open access: yesJournal of Open Research Software, 2021
auto{API} is a web-based tool for the specification and management of API endpoints to online XML data sources. The APIs generated return the data in JSON format. The tool allows users to specify the field names to be used in the JSON data and to control
Adrian Moore
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

A Study of Malaria in Bangladesh

open access: yesAssam Journal of Internal Medicine, 2022
Background: Malaria still occurs in Bangladesh which is one of the countries of the South-east Asia region. Materials and Methods: The study design included an online search of all data pertaining to Malaria in Bangladesh from the year 2020 onwards ...
Arvind Nath
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

A security analysis of authentication and authorization implemented in web applications based on the REST architecture

open access: yesJournal of Computer Sciences Institute, 2020
The purpose of this article is to prepare a security analysis of authentication and authorization mechanisms in web applications based on the REST architecture. The article analyzes the problems encountered during the implementation of the JSON Web Token
Tomasz Muszyński, Grzegorz Koziel
doaj   +1 more source

APIE DENOTACIJĄ

open access: yesProblemos, 2012
Bertrando Russello "On Denoting" vertimas į lietuvių kalbą. Vertė Jonas Dagys. 
openaire   +4 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

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