Results 41 to 50 of about 117,184 (267)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Calculated oscillator strengths and transition probabilities of singly ionised nickel (Ni II)

Astronomy & Astrophysics
Aims. This work reports calculated transition probabilities for spectral lines of singly ionised nickel (Ni II) incorporating newly determined experimental energy levels, addressing critical gaps in atomic data required for astrophysical spectroscopy and
Clear Christian P., Uylings Peter, Raassen Ton   +2 more
doaj   +1 more source

Deep API Programmer: Learning to Program with APIs

CoRR, 2017
We present DAPIP, a Programming-By-Example system that learns to program with APIs to perform data transformation tasks. We design a domain-specific language (DSL) that allows for arbitrary concatenations of API outputs and constant strings. The DSL consists of three family of APIs: regular expression-based APIs, lookup APIs, and transformation APIs ...
Surya Bhupatiraju, Rishabh Singh, Abdel-rahman Mohamed, Pushmeet Kohli   +3 more
openaire   +2 more sources

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Modul Front-End Sistem Informasi Geospasial Patroli Terpadu Kebakaran Hutan dan Lahan

Jurnal RESTI (Rekayasa Sistem dan Teknologi Informasi), 2021
To prevent and handle forest and land and forest fire (karhutla), the Ministry of Environment and Forestry assembled a patrol team that conducts a daily task to observe directly to the hotspot location as an indication for land fire.
Deny Ramdhany, Imas Sukaesih Sitanggang, Ikhsan Kurniawan, Wulandari Wulandari   +3 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Deep API learning

Proceedings of the 2016 24th ACM SIGSOFT International Symposium on Foundations of Software Engineering, 2016
Developers often wonder how to implement a certain functionality (e.g., how to parse XML files) using APIs. Obtaining an API usage sequence based on an API-related natural language query is very helpful in this regard. Given a query, existing approaches utilize information retrieval models to search for matching API sequences.
Xiaodong Gu 0002, Hongyu Zhang 0002, Dongmei Zhang 0001, Sunghun Kim 0001   +3 more
openaire   +2 more sources

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source