Results 51 to 60 of about 116,267 (267)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Multitek Indonesia, 2020 Kebakaran merupakan bencana yang tidak dapat diprediksi dan dapat terjadi kapan saja. Ketika kebakaran terjadi, sebelum satuan pemadam kebakaran tiba di lokasi kejadian, biasanya upaya pemadaman dilakukan oleh warga setempat
Rima Riyanti +2 more
doaj +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Emitor: Jurnal Teknik Elektro, 2020 Hujan merupakan faktor penting dalam segala aspek kehidupan, tidak tentunya kedatangan hujan saat ini sangat berpengaruh terhadap kegiatan industri, terutama pada sektor pertanian.
Satrio Setyo Laksono, N Nurgiyatna
doaj +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Governify for APIs: SLA-driven ecosystem for API governance
Proceedings of the 2019 27th ACM Joint Meeting on European Software Engineering Conference and Symposium on the Foundations of Software Engineering, 2019 As software architecture design is evolving to a microservice paradigm, RESTful APIs are being established as the preferred choice to build applications. In such a scenario, there is a shift towards a growing market of APIs where providers offer different service levels with tailored limitations typically based on the cost.
Antonio Gamez-Diaz +2 more
openaire +3 more sources
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Using Simio to automatically create 3D warehouses and compare different storage strategies [PDF]
FME Transactions, 2015 This paper focuses on a simulation based approach to reduce warehouse costs. At an early stage, the tool needs to be able to generate different types of warehouses.
Vieira António +5 more
doaj
Sistem Informasi Akademik untuk Layanan Mahasiswa UMS berbasis Mobile
Emitor: Jurnal Teknik Elektro, 2017 Pemanfaatan teknologi terkait penyampaian informasi dalam dunia akademik kini mulai bergeser dari teknologi web menjadi teknologi mobile yang lebih fleksibel, efektif, dan efisien.Meningkatnya akses informasi secara mobile tanpa diimbangi pengembangan ...
Hanif Amrullah, Bana Handaga
doaj +1 more source