Results 11 to 20 of about 17,951 (220)

Dichloroacetate and Pyruvate Metabolism: Pyruvate Dehydrogenase Kinases as Targets Worth Investigating for Effective Therapy of Toxoplasmosis

open access: yesmSphere, 2021
Currently, the drugs used for toxoplasmosis have severe toxicity to human cells, and the treatment still lacks effective and safer alternatives. The search for novel drug targets is timely.
Mariana Galvão Ferrarini   +12 more
doaj   +1 more source

Extrachromosomal DNA in the Apicomplexa. [PDF]

open access: yesMicrobiology and molecular biology reviews : MMBR, 1997
Malaria and related apicomplexan parasites have two highly conserved organellar genomes: one is of plastid (pl) origin, and the other is mitochondrial (mt). The organization of both organellar DNA molecules from the human malaria parasite Plasmodium falciparum has been determined, and they have been shown to be tightly packed with genes.
R J, Wilson, D H, Williamson
openaire   +3 more sources

Secondary Structure and X-ray Crystallographic Analysis of the Glideosome-Associated Connector (GAC) from Toxoplasma gondii

open access: yesCrystals, 2022
A model for parasitic motility has been proposed in which parasite filamentous actin (F-actin) is attached to surface adhesins by a large component of the glideosome, known as the glideosome-associated connector protein (GAC).
Amit Kumar   +8 more
doaj   +1 more source

Identification and Validation of Toxoplasma gondii Mitoribosomal Large Subunit Components

open access: yesMicroorganisms, 2022
Mitochondrial ribosomes are fundamental to mitochondrial function, and thus survival, of nearly all eukaryotes. Despite their common ancestry, mitoribosomes have evolved divergent features in different eukaryotic lineages.
Shikha Shikha   +2 more
doaj   +1 more source

Circadian rhythms and circadian clock gene homologs of complex alga Chromera velia

open access: yesFrontiers in Plant Science, 2023
Most organisms on Earth are affected by periodic changes in their environment. The circadian clock is an endogenous device that synchronizes behavior, physiology, or biochemical processes to an approximately 24-hour cycle, allowing organisms to ...
Jitka Richtová   +10 more
doaj   +1 more source

Case report: Sarcocystis speeri, Aspergillus fumigatus, and novel Treponema sp. infections in an adult Atlantic spotted dolphin (Stenella frontalis)

open access: yesFrontiers in Veterinary Science, 2023
A complete postmortem examination, including a computed tomography scan “virtopsy” (virtual necropsy), gross necropsy, cytology, histology, and molecular diagnostics were performed to investigate the cause of death of a deceased adult male Atlantic ...
Sarah Emily Balik   +10 more
doaj   +1 more source

Immunotherapy With Egg Yolk Eimeria sp.-Specific Immunoglobulins in SPF Leghorn Chicks Elicits Successful Protection Against Eimeria tenella Infection

open access: yesFrontiers in Veterinary Science, 2021
Avian coccidiosis is the first to most economically important parasite disease affecting poultry industries worldwide. Current prevention measures are largely based upon prophylactic chemotherapy supplemented by the application of live attenuated or wild-
Marco A. Juárez-Estrada   +4 more
doaj   +1 more source

Rosettes integrity protects Plasmodium vivax of being phagocytized

open access: yesScientific Reports, 2020
Plasmodium vivax is the most prevalent cause of malaria outside of Africa. P. vivax biology and pathogenesis are still poorly understood. The role of one highly occurring phenotype in particular where infected reticulocytes cytoadhere to noninfected ...
Letusa Albrecht   +16 more
doaj   +1 more source

The Long and Short of Next Generation Sequencing for Cryptosporidium Research

open access: yesFrontiers in Cellular and Infection Microbiology, 2022
The intestinal parasite Cryptosporidium is a significant cause of severe diarrhoeal disease that can have long term effects. Therapeutic options remain limited despite a significant impact on public health, partly due to various challenges in the field ...
Tapoka T. Mkandawire, Adam Sateriale
doaj   +1 more source

Colpodella sp. (ATCC 50594) Life Cycle: Myzocytosis and Possible Links to the Origin of Intracellular Parasitism

open access: yesTropical Medicine and Infectious Disease, 2021
Colpodella species are free living bi-flagellated protists that prey on algae and bodonids in a process known as myzocytosis. Colpodella species are phylogenetically related to Apicomplexa. We investigated the life cycle of Colpodella sp. (ATCC 50594) to
Troy A. Getty   +4 more
doaj   +1 more source

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