Results 171 to 180 of about 17,169 (224)

New proteins in the apicoplast membranes: time to rethink apicoplast protein targeting

Trends in Parasitology, 2009
Several apicomplexan parasites harbour an essential plastid known as the apicoplast. Apicoplasts import proteins and metabolites for several biological functions, but how import is achieved is largely unknown. Two recent reports have identified novel proteins in the apicoplast membranes, providing new perspectives on how proteins traffic to this ...
Liting, Lim, Ming, Kalanon, Geoffrey I, McFadden   +2 more
openaire   +2 more sources

Targeting apicoplasts in malaria parasites

Expert Opinion on Therapeutic Targets, 2012
The relict plastid, or apicoplast, is a characteristic feature of Plasmodium spp. and reflects the unusual evolutionary origins of these parasites. The essential role this organelle plays in the life of the parasite, and its unusual, non-mammalian metabolism, make the apicoplast an excellent drug target.This review focuses on the biological role of the
Christopher D, Goodman, Geoffrey I, McFadden   +1 more
openaire   +2 more sources

The apicoplast as an antimalarial drug target

Drug Resistance Updates, 2001
Resistance to commonly used malaria drugs is spreading and new drugs are required urgently. The recent identification of a relict chloroplast (apicoplast) in malaria and related parasites offers numerous new targets for drug therapy using well-characterized compounds. The apicoplast contains a range of metabolic pathways and housekeeping processes that
S A, Ralph, M C, D'Ombrain, G I, McFadden   +2 more
openaire   +2 more sources

A Green Algal Apicoplast Ancestor

Science, 2002
Apicomplexan parasites, including the human pathogens Toxoplasma and Plasmodium , contain a vestigial plastid, the apicoplast. This chloroplast-derived organelle is the remnant of a secondary endosymbiosis between an ancestral apicomplexan and a photosynthetic organism whose origin is moot ([1–4][
Soledad, Funes, Edgar, Davidson, Adrián, Reyes-Prieto, Susana, Magallón, Pascal, Herion, Michael P, King, Diego, González-Halphen   +6 more
openaire   +2 more sources

Metabolic Pathways in the Apicoplast of Apicomplexa

2010
Intracellular parasites of the phylum Apicomplexa harbor a plastid-like organelle called apicoplast that is the most reduced organelle of this type known. Due to the medical importance of some members of Apicomplexa, a number of fully sequenced genomes are available that have allowed to assemble metabolic pathways also from the apicoplast and have ...
Seeber, Frank, Soldati-Favre, Dominique
openaire   +3 more sources

Toxoplasma gondii autophagy-related protein ATG7 maintains apicoplast inheritance by stabilizing and lipidating ATG8.

Biochimica et Biophysica Acta - Molecular Basis of Disease, 2023
ATG8/LC3-mediated autophagosome formation is a key rate-limiting step in the process of autophagy. The parasitic protist Toxoplasma gondii possesses a single ATG8 homolog (TgATG8), which can localize to either cytosolic autophagosome involved in delivery
Mimi Wu, Jiaqi Ying, Xuejing Lin, Chao Xu, Xiaozi Zheng, Yipeng Zheng, Zhouxi Fang, Baolong Yan, Nu Zhang, Ya-ni Mou, Feng Tan   +10 more
semanticscholar   +1 more source

Isoprenoid Biosynthesis of the Apicoplast as Drug Target

Current Drug Targets, 2007
In Plasmodium falciparum the biosynthesis of isoprenoids is achieved by the mevalonate-independent 1-deoxy-d-xylulose 5-phosphate (DOXP) pathway. The enzymes of the DOXP pathway are localised inside the plastid-like organelle (apicoplast). Fosmidomycin inhibits DOXP reductoisomerase, the second enzyme of this pathway.
Jochen, Wiesner, Hassan, Jomaa
openaire   +2 more sources

The Apicoplast: A Key Target to Cure Malaria

Current Pharmaceutical Design, 2012
Malaria is one of the major global health problems. About 500 million humans are infected each year, and 1 million, mostly African children, die from malaria annually. No vaccine is yet in sight, and those drugs that have previously served us well are now losing ground against the disease as parasites become resistant to our best compounds.
Macrae, James I, Maréchal, Eric, Biot, Christophe, Botté, Cyrille y   +3 more
openaire   +3 more sources

A kalihinol analog disrupts apicoplast function and vesicular trafficking in P. falciparum malaria

Science
We report the discovery of MED6-189, an analog of the kalihinol family of isocyanoterpene natural products that is effective against drug-sensitive and drug-resistant Plasmodium falciparum strains, blocking both asexual replication and sexual ...
Z. Chahine, S. Abel, T. Hollin, G. Barnes, J. Chung, M. Daub, I. Renard, J. Choi, P. Vydyam, A. Pal, M. Alba-Argomaniz, C. Banks, J. Kirkwood, A. Saraf, I. Camino, P. Castaneda, M. Cuevas, J. De Mercado-Arnanz, E. Fernandez-Alvaro, A. Garcia-Perez, N. Ibarz, S. Viera-Morilla, J. Prudhomme, C. Joyner, A. Bei, L. Florens, C. Ben Mamoun, C. Vanderwal, K. L. Le Roch   +28 more
semanticscholar   +1 more source

The apicoplast: a new member of the plastid family

Trends in Plant Science, 2001
Protozoan parasites of the phylum Apicomplexa include pathogens such as Plasmodium, Toxoplasma and Cryptosporidium. They have been shown to contain a vestigial nonphotosynthetic plastid, the apicoplast, which might have arisen by secondary endosymbiosis.
E, Maréchal, M F, Cesbron-Delauw
openaire   +2 more sources