Results 161 to 170 of about 17,169 (224)

Genome assembly and annotation of Babesia rossi, a protozoan parasite for canine babesiosis. [PDF]

BMC Genomics
Redekar N, Wang X, Neves L, Brooks S, Lack J, Leisewitz A, Ackerman H.   +6 more
europepmc   +1 more source

Structural basis of multitasking by the apicoplast DNA polymerase from Plasmodium falciparum

Kumari A, Enache T, Craggs TD, Pata JD, Lahiri I.   +4 more
europepmc   +1 more source

Exploiting the apicoplast: apicoplast-targeting drugs and malaria vaccine development [PDF]

Microbes and Infection, 2018
The apicoplast, a relic plastid found in most Apicomplexan parasites, is a notable drug target. Certain antibiotics elicit a delayed death phenotype by targeting this organelle. Here, we review apicoplast-targeting drugs and their targets, particularly those that cause delayed death, and highlight its potential uses in malaria vaccine development.
Leanne M Low, Danielle I． Stanisic, Michael F Good   +2 more
exaly   +5 more sources

The evolution, metabolism and functions of the apicoplast [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2010
The malaria parasite,Plasmodium falciparum, harbours a relict plastid known as the ‘apicoplast’. The discovery of the apicoplast ushered in an exciting new prospect for drug development against the parasite. The eubacterial ancestry of the organelle offers a wealth of opportunities for the development of therapeutic interventions.
Geoffrey I Mcfadden
exaly   +6 more sources

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The apicoplast

Protoplasma, 2010
Parasites like malaria and Toxoplasma possess a vestigial plastid homologous to the chloroplasts of plants. The plastid (known as the apicoplast) is non-photosynthetic but retains many hallmarks of its ancestry including a circular genome that it synthesises proteins from and a suite of biosynthetic pathways of cyanobacterial origin.
Geoffrey I Mcfadden
exaly   +3 more sources

Validation of Putative Apicoplast-Targeting Drugs Using a Chemical Supplementation Assay in Cultured Human Malaria Parasites

Antimicrobial Agents and Chemotherapy, 2018
Malaria parasites contain a relict plastid, the apicoplast, which is considered an excellent drug target due to its bacterial-like ancestry. Numerous parasiticidals have been proposed to target the apicoplast, but few have had their actual targets ...
Geoffrey I Mcfadden, Christopher D Goodman   +1 more
exaly   +2 more sources

Apicoplast: keep it or leave it

Microbes and Infection, 2010
Most Apicomplexans possess a relic plastid named apicoplast, originating from secondary endosymbiosis of a red algae. This non-photosynthetic organelle fulfils important metabolic functions and confers sensitivity to antibiotics. The tasks of this organelle is compared across the phylum of Apicomplexa, highlighting its role in metabolic adaptation to ...
Fleige, Tobias, Limenitakis, Julien, Soldati-Favre, Dominique   +2 more
openaire   +4 more sources

Apicoplast genome of the coccidian Eimeria tenella

Gene, 2003
Unicellular apicomplexans possess an algal-originated plastid referred to as an apicoplast. Although apicomplexan parasites are comprised of highly diverse protists, the complete apicoplast genome sequences have only been determined from the hematozoan Plasmodium falciparum and cyst-forming coccidian Toxoplasma gondii.
Xiaomin Cai, Larry R Mcdougald, Guan Zhu   +2 more
exaly   +3 more sources