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Apicoplast Metabolism: Parasite’s Achilles’ Heel
Current Topics in Medicinal Chemistry, 2019Malaria continues to impinge heavily on mankind, with five continents still under its clasp. Widespread and rapid emergence of drug resistance in the Plasmodium parasite to current therapies accentuate the quest for novel drug targets and antimalarial compounds. Plasmodium parasites, maintain a non-photosynthetic relict organelle known as Apicoplast.
Kavita, Kadian +4 more
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The Apicoplast: A Key Target to Cure Malaria
Current Pharmaceutical Design, 2012Malaria is one of the major global health problems. About 500 million humans are infected each year, and 1 million, mostly African children, die from malaria annually. No vaccine is yet in sight, and those drugs that have previously served us well are now losing ground against the disease as parasites become resistant to our best compounds.
Macrae, James I +3 more
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The Apicoplast: A Parasite’s Symbiont
2014The endosymbiotic capture of a red alga brought photosynthesis to a previously heterotrophic protist, and marked the birth of a now very diverse new branch of the eukaryotic tree of life. Among the many plastid-bearing descendants of this event are the Apicomplexa, a phylum of obligate animal parasites.
Lilach Sheiner, Boris Striepen
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Comment on "A Green Algal Apicoplast Ancestor"
Science, 2003Discovery of a plastid in apicomplexan parasites such as Toxoplasma and Plasmodium ( [1][1], [2][2] ) has prompted intense debate over whether the plastid originates from a red algal or a green algal ancestor ( [3][3]–[5][4] ). Funes et al.
Ross F, Waller +3 more
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Phylogeny and evolution of apicoplasts and apicomplexan parasites
Parasitology International, 2015The phylum Apicomplexa includes many parasitic genera of medical and veterinary importance including Plasmodium (causative agent of malaria), Toxoplasma (toxoplasmosis), and Babesia (babesiosis). Most of the apicomplexan parasites possess a unique, essential organelle, the apicoplast, which is a plastid without photosynthetic ability.
Nobuko Arisue, Tetsuo Hashimoto
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The apicoplast: a new member of the plastid family
Trends in Plant Science, 2001Protozoan parasites of the phylum Apicomplexa include pathogens such as Plasmodium, Toxoplasma and Cryptosporidium. They have been shown to contain a vestigial nonphotosynthetic plastid, the apicoplast, which might have arisen by secondary endosymbiosis.
E, Maréchal, M F, Cesbron-Delauw
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Apicomplexan Protozoonlarda Apicoplast
2017Apicomplexa subphylumunda bulunanprotistan türleri fotosentetik olmayan apicoplast adı verilen ikincil birplastide sahiptirler. Apicoplast; Plasmodium,Eimeria, Toxoplasma, Sarcocystis, Theileriave Babesia gibi bazı apicomplexanprotozoonlarda bulunan buna karşılık Cryptosporidiumspp ve Gregarina niphandrodes’debulunmayan bir plastiddir.
İNCİ, Abdullah +3 more
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