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Protoplasma, 2010
Parasites like malaria and Toxoplasma possess a vestigial plastid homologous to the chloroplasts of plants. The plastid (known as the apicoplast) is non-photosynthetic but retains many hallmarks of its ancestry including a circular genome that it synthesises proteins from and a suite of biosynthetic pathways of cyanobacterial origin.
Geoff McFadden
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Parasites like malaria and Toxoplasma possess a vestigial plastid homologous to the chloroplasts of plants. The plastid (known as the apicoplast) is non-photosynthetic but retains many hallmarks of its ancestry including a circular genome that it synthesises proteins from and a suite of biosynthetic pathways of cyanobacterial origin.
Geoff McFadden
exaly +3 more sources
TgKDAC4: A Unique Deacetylase of Toxoplasma’s Apicoplast
Microorganisms, 2023 Toxoplasma gondii is an obligate intracellular parasite of the phylum Apicomplexa and causes toxoplasmosis infections, a disease that affects a quarter of the world’s population and has no effective cure.
Andrea Rodrigues Avila +2 more
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Apicoplast: keep it or leave it
Microbes and Infection, 2010Most Apicomplexans possess a relic plastid named apicoplast, originating from secondary endosymbiosis of a red algae. This non-photosynthetic organelle fulfils important metabolic functions and confers sensitivity to antibiotics. The tasks of this organelle is compared across the phylum of Apicomplexa, highlighting its role in metabolic adaptation to ...
Fleige, Tobias +2 more
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New proteins in the apicoplast membranes: time to rethink apicoplast protein targeting
Trends in Parasitology, 2009Several apicomplexan parasites harbour an essential plastid known as the apicoplast. Apicoplasts import proteins and metabolites for several biological functions, but how import is achieved is largely unknown. Two recent reports have identified novel proteins in the apicoplast membranes, providing new perspectives on how proteins traffic to this ...
Liting, Lim +2 more
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The apicoplast as an antimalarial drug target
Drug Resistance Updates, 2001Resistance to commonly used malaria drugs is spreading and new drugs are required urgently. The recent identification of a relict chloroplast (apicoplast) in malaria and related parasites offers numerous new targets for drug therapy using well-characterized compounds. The apicoplast contains a range of metabolic pathways and housekeeping processes that
S A, Ralph +2 more
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Targeting apicoplasts in malaria parasites
Expert Opinion on Therapeutic Targets, 2012The relict plastid, or apicoplast, is a characteristic feature of Plasmodium spp. and reflects the unusual evolutionary origins of these parasites. The essential role this organelle plays in the life of the parasite, and its unusual, non-mammalian metabolism, make the apicoplast an excellent drug target.This review focuses on the biological role of the
Christopher D, Goodman +1 more
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A Green Algal Apicoplast Ancestor
Science, 2002Apicomplexan parasites, including the human pathogens Toxoplasma and Plasmodium , contain a vestigial plastid, the apicoplast. This chloroplast-derived organelle is the remnant of a secondary endosymbiosis between an ancestral apicomplexan and a photosynthetic organism whose origin is moot ([1–4][
Soledad, Funes +6 more
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Apicoplast genome of the coccidian Eimeria tenella
Gene, 2003Unicellular apicomplexans possess an algal-originated plastid referred to as an apicoplast. Although apicomplexan parasites are comprised of highly diverse protists, the complete apicoplast genome sequences have only been determined from the hematozoan Plasmodium falciparum and cyst-forming coccidian Toxoplasma gondii.
Guan Zhu +2 more
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Metabolic Pathways in the Apicoplast of Apicomplexa
2010Intracellular parasites of the phylum Apicomplexa harbor a plastid-like organelle called apicoplast that is the most reduced organelle of this type known. Due to the medical importance of some members of Apicomplexa, a number of fully sequenced genomes are available that have allowed to assemble metabolic pathways also from the apicoplast and have ...
Seeber, Frank, Soldati-Favre, Dominique
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Isoprenoid Biosynthesis of the Apicoplast as Drug Target
Current Drug Targets, 2007In Plasmodium falciparum the biosynthesis of isoprenoids is achieved by the mevalonate-independent 1-deoxy-d-xylulose 5-phosphate (DOXP) pathway. The enzymes of the DOXP pathway are localised inside the plastid-like organelle (apicoplast). Fosmidomycin inhibits DOXP reductoisomerase, the second enzyme of this pathway.
Jochen, Wiesner, Hassan, Jomaa
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