Results 131 to 140 of about 14,922 (172)
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The apicoplast as an antimalarial drug target
Drug Resistance Updates, 2001Resistance to commonly used malaria drugs is spreading and new drugs are required urgently. The recent identification of a relict chloroplast (apicoplast) in malaria and related parasites offers numerous new targets for drug therapy using well-characterized compounds. The apicoplast contains a range of metabolic pathways and housekeeping processes that
S A, Ralph +2 more
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A Green Algal Apicoplast Ancestor
Science, 2002Apicomplexan parasites, including the human pathogens Toxoplasma and Plasmodium , contain a vestigial plastid, the apicoplast. This chloroplast-derived organelle is the remnant of a secondary endosymbiosis between an ancestral apicomplexan and a photosynthetic organism whose origin is moot ([1–4][
Soledad, Funes +6 more
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Metabolic Pathways in the Apicoplast of Apicomplexa
2010Intracellular parasites of the phylum Apicomplexa harbor a plastid-like organelle called apicoplast that is the most reduced organelle of this type known. Due to the medical importance of some members of Apicomplexa, a number of fully sequenced genomes are available that have allowed to assemble metabolic pathways also from the apicoplast and have ...
Seeber, Frank, Soldati-Favre, Dominique
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Isoprenoid Biosynthesis of the Apicoplast as Drug Target
Current Drug Targets, 2007In Plasmodium falciparum the biosynthesis of isoprenoids is achieved by the mevalonate-independent 1-deoxy-d-xylulose 5-phosphate (DOXP) pathway. The enzymes of the DOXP pathway are localised inside the plastid-like organelle (apicoplast). Fosmidomycin inhibits DOXP reductoisomerase, the second enzyme of this pathway.
Jochen, Wiesner, Hassan, Jomaa
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The Apicoplast: A Key Target to Cure Malaria
Current Pharmaceutical Design, 2012Malaria is one of the major global health problems. About 500 million humans are infected each year, and 1 million, mostly African children, die from malaria annually. No vaccine is yet in sight, and those drugs that have previously served us well are now losing ground against the disease as parasites become resistant to our best compounds.
Macrae, James I +3 more
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The Apicoplast: A Parasite’s Symbiont
2014The endosymbiotic capture of a red alga brought photosynthesis to a previously heterotrophic protist, and marked the birth of a now very diverse new branch of the eukaryotic tree of life. Among the many plastid-bearing descendants of this event are the Apicomplexa, a phylum of obligate animal parasites.
Lilach Sheiner, Boris Striepen
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The apicoplast: a new member of the plastid family
Trends in Plant Science, 2001Protozoan parasites of the phylum Apicomplexa include pathogens such as Plasmodium, Toxoplasma and Cryptosporidium. They have been shown to contain a vestigial nonphotosynthetic plastid, the apicoplast, which might have arisen by secondary endosymbiosis.
E, Maréchal, M F, Cesbron-Delauw
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Comment on "A Green Algal Apicoplast Ancestor"
Science, 2003Discovery of a plastid in apicomplexan parasites such as Toxoplasma and Plasmodium ( [1][1], [2][2] ) has prompted intense debate over whether the plastid originates from a red algal or a green algal ancestor ( [3][3]–[5][4] ). Funes et al.
Ross F, Waller +3 more
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Phylogeny and evolution of apicoplasts and apicomplexan parasites
Parasitology International, 2015The phylum Apicomplexa includes many parasitic genera of medical and veterinary importance including Plasmodium (causative agent of malaria), Toxoplasma (toxoplasmosis), and Babesia (babesiosis). Most of the apicomplexan parasites possess a unique, essential organelle, the apicoplast, which is a plastid without photosynthetic ability.
Nobuko Arisue, Tetsuo Hashimoto
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Apicoplast Metabolism: Parasite’s Achilles’ Heel
Current Topics in Medicinal Chemistry, 2019Malaria continues to impinge heavily on mankind, with five continents still under its clasp. Widespread and rapid emergence of drug resistance in the Plasmodium parasite to current therapies accentuate the quest for novel drug targets and antimalarial compounds. Plasmodium parasites, maintain a non-photosynthetic relict organelle known as Apicoplast.
Kavita, Kadian +4 more
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