Results 121 to 130 of about 14,891 (174)

The spatial proteome of the Plasmodium falciparum schizont illuminates the composition and evolutionary trajectories of its organelles

Chisholm SA, Flores V, Kemp A, Breckels LM, Koreny L, Santos Pacheco ND, Barylyuk K, Kuroshchenkova A, Lilley KS, Rayner JC, Waller RF.   +10 more
europepmc   +1 more source

Structural basis of multitasking by the apicoplast DNA polymerase from Plasmodium falciparum

Kumari A, Enache T, Craggs TD, Pata JD, Lahiri I.   +4 more
europepmc   +1 more source

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The apicoplast

Protoplasma, 2010
Parasites like malaria and Toxoplasma possess a vestigial plastid homologous to the chloroplasts of plants. The plastid (known as the apicoplast) is non-photosynthetic but retains many hallmarks of its ancestry including a circular genome that it synthesises proteins from and a suite of biosynthetic pathways of cyanobacterial origin.
Geoff Mcfadden
exaly   +3 more sources

Exploiting the apicoplast: apicoplast-targeting drugs and malaria vaccine development [PDF]

Microbes and Infection, 2018
The apicoplast, a relic plastid found in most Apicomplexan parasites, is a notable drug target. Certain antibiotics elicit a delayed death phenotype by targeting this organelle. Here, we review apicoplast-targeting drugs and their targets, particularly those that cause delayed death, and highlight its potential uses in malaria vaccine development.
Michael Good, Leanne M Low, Danielle Stanisic   +2 more
exaly   +4 more sources

The evolution, metabolism and functions of the apicoplast [PDF]

Philosophical Transactions of the Royal Society B: Biological Sciences, 2010
The malaria parasite, Plasmodium falciparum , harbours a relict plastid known as the ‘apicoplast’. The discovery of the apicoplast ushered in an exciting new prospect for drug development against the parasite.
Geoff Mcfadden
exaly   +4 more sources

Apicoplast: keep it or leave it

Microbes and Infection, 2010
Most Apicomplexans possess a relic plastid named apicoplast, originating from secondary endosymbiosis of a red algae. This non-photosynthetic organelle fulfils important metabolic functions and confers sensitivity to antibiotics. The tasks of this organelle is compared across the phylum of Apicomplexa, highlighting its role in metabolic adaptation to ...
Fleige, Tobias, Limenitakis, Julien, Soldati-Favre, Dominique   +2 more
openaire   +4 more sources

Apicoplast genome of the coccidian Eimeria tenella

Gene, 2003
Unicellular apicomplexans possess an algal-originated plastid referred to as an apicoplast. Although apicomplexan parasites are comprised of highly diverse protists, the complete apicoplast genome sequences have only been determined from the hematozoan Plasmodium falciparum and cyst-forming coccidian Toxoplasma gondii.
Guan Zhu, Xiaomin Cai, Larry R Mcdougald   +2 more
exaly   +3 more sources

New proteins in the apicoplast membranes: time to rethink apicoplast protein targeting

Trends in Parasitology, 2009
Several apicomplexan parasites harbour an essential plastid known as the apicoplast. Apicoplasts import proteins and metabolites for several biological functions, but how import is achieved is largely unknown. Two recent reports have identified novel proteins in the apicoplast membranes, providing new perspectives on how proteins traffic to this ...
Liting, Lim, Ming, Kalanon, Geoffrey I, McFadden   +2 more
openaire   +2 more sources