Results 101 to 110 of about 16,726 (193)

Toxoplasma gondii devoid of an apicoplast - Addition

This is an addition to a previously published dataset termed 'Toxoplasma gondii devoid of an apicoplast', accessible under 10.26037/yareta:kc446nwxifbvtb5z7l2f6tayga This dataset is associated with a study describing the investigation of Toxoplasma ...
von Rohr, Olivier, Bonavoglia, Alessandro, Koszti, Szilamer, Chen, Min, Peng, Hongjuan, Soldati-Favre, Dominique, Kloehn, Joachim   +6 more
core   +1 more source

The apicoplast of Plasmodium falciparum is translationally active

, 2005
Summary: Apicoplast, the plastid-like organelle of apicomplexan parasites, has generated interest as a putative drug target. Although transcripts for genes encoded by the 35 kb circular plastid DNA have been detected, the actual presence of their protein
Chaubey, Sushma, Singh, Divya, Kumar, Ambrish, Habib, Saman   +3 more
core   +1 more source

A pyruvate transporter in the apicoplast of apicomplexan parasites

Proceedings of the National Academy of Sciences
Pyruvate lies at a pivotal node of carbon metabolism in eukaryotes. It is involved in diverse metabolic pathways in multiple organelles, and its interorganelle shuttling is crucial for cell fitness. Many apicomplexan parasites harbor a unique organelle called the apicoplast that houses metabolic pathways like fatty acid and ...
Pu Chen, Yukun Chen, Ningbo Xia, Bolin Fan, Zhipeng Niu, Zhengming He, Xu Wang, Jing Yuan, Nishith Gupta, Bang Shen   +9 more
openaire   +2 more sources

Apicoplast [PDF]

Current Biology, 2014
openaire   +2 more sources

Apicoplast-Resident Processes: Exploiting the Chink in the Armour of Plasmodium falciparum Parasites

Advances in Pharmacological and Pharmaceutical Sciences
The discovery of a relict plastid, also known as an apicoplast (apicomplexan plastid), that houses housekeeping processes and metabolic pathways critical to Plasmodium parasites’ survival has prompted increased research on identifying potent inhibitors ...
Collins Ojonugwa Mamudu, Mercy Eyitomi Tebamifor, Mary Ohunene Sule, Titilope Modupe Dokunmu, Olubanke Olujoke Ogunlana, Franklyn Nonso Iheagwam   +5 more
doaj   +1 more source

The Toxoplasma monocarboxylate transporters are involved in the metabolism within the apicoplast and are linked to parasite survival

eLife
The apicoplast is a four-membrane plastid found in the apicomplexans, which harbors biosynthesis and organelle housekeeping activities in the matrix. However, the mechanism driving the flux of metabolites, in and out, remains unknown.
Hui Dong, Jiong Yang, Kai He, Wen-Bin Zheng, De-Hua Lai, Jing Liu, Hui-Yong Ding, Rui-Bin Wu, Kevin M Brown, Geoff Hide, Zhao-Rong Lun, Xing-Quan Zhu, Shaojun Long   +12 more
doaj   +1 more source

Validation of Putative Apicoplast-Targeting Drugs Using a Chemical Supplementation Assay in Cultured Human Malaria Parasites

, 2018
Malaria parasites contain a relict plastid, the apicoplast, which is considered an excellent drug target due to its bacterial-like ancestry. Numerous parasiticidals have been proposed to target the apicoplast, but few have had their actual targets ...
Christopher Dean Goodman, Taher Uddin, Geoffrey Ian McFadden   +2 more
core   +1 more source

The dynamin-related protein PfDyn2 is essential for both apicoplast and mitochondrial fission in Plasmodium falciparum

mBio
Dynamins, or dynamin-related proteins (DRPs), are large mechano-sensitive GTPases that mediate membrane dynamics or organellar fission/fusion events. Plasmodium falciparum encodes three dynamin-like proteins whose functions are poorly understood.
Alexander A. Morano, Wei Xu, Francesca M. Navarro, Neeta Shadija, Jeffrey D. Dvorin, Hangjun Ke   +5 more
doaj   +1 more source

Dissecting apicoplast targeting in plasmodium falciparum and toxoplasma gondii

, 2004
Typescript (photocopy)Thesis (PhD) -- University of Melbourne, Faculty of Science, 2004Includes bibliographical references (leaves 190-206)CD-ROM content not included in digitised versionThe phylum Apicomplexa is a group of obligate intracellular ...
Tonkin, Christopher J. (Christopher John)
core   +1 more source

The Function of the apicoplast in the malaria parasite, plasmodium falciparum

, 2003
Typescript (photocopy)Thesis (PhD) -- University of Melbourne, Faculty of Science, 2003Includes bibliographical references (leaves 167-195)Apicomplexan parasites such as Plasmodium falciparum and Toxoplasma gondii contain a relict plastid (the apicoplast)
Ralph, Stuart Alexander.
core   +1 more source