Results 101 to 110 of about 17,169 (224)

Plasmodium apicoplast tyrosyl-tRNA synthetase recognizes an unusual, simplified identity set in cognate tRNATyr.

PLoS ONE, 2018
The life cycle of Plasmodium falciparum, the agent responsible for malaria, depends on both cytosolic and apicoplast translation fidelity. Apicoplast aminoacyl-tRNA synthetases (aaRS) are bacterial-like enzymes devoted to organellar tRNA aminoacylation ...
Marta Cela, Caroline Paulus, Manuel A S Santos, Gabriela R Moura, Magali Frugier, Joëlle Rudinger-Thirion   +5 more
doaj   +1 more source

Malaria parasites require a divergent heme oxygenase for apicoplast gene expression and biogenesis

bioRxiv
Malaria parasites have evolved unusual metabolic adaptations that specialize them for growth within heme-rich human erythrocytes. During blood-stage infection, Plasmodium falciparum parasites internalize and digest abundant host hemoglobin within the ...
A. M. Blackwell, Y. Jami-Alahmadi, Armiyaw S. Nasamu, S. Kudo, A. Senoo, Celine Slam, Kouhei Tsumoto, James A. Wohlschlegel, J. Caaveiro, Daniel E. Goldberg, P. Sigala   +10 more
semanticscholar   +1 more source

There Is Treasure Everywhere: Reductive Plastid Evolution in Apicomplexa in Light of Their Close Relatives

Biomolecules, 2019
The phylum Apicomplexa (Alveolates) comprises a group of host-associated protists, predominately intracellular parasites, including devastating parasites like Plasmodium falciparum, the causative agent of malaria.
Eric D. Salomaki, Martin Kolisko
doaj   +1 more source

Toxoplasma gondii devoid of an apicoplast

Several medically relevant Apicomplexa critically rely on the apicoplast, a remnant plastid organelle derived from secondary endosymbiosis. The apicoplast has lost its photosynthetic function but harbors essential metabolic pathways.
Maco, Bohumil, Bonavoglia, Alessandro, Koszti, Szilamer, Chen, Min, Peng, Hongjuan, Soldati-Favre, Dominique, Kloehn, Joachim   +6 more
core   +1 more source

Mitochondrial and apicoplast genome copy abundances of haemosporidian parasites are explained by host species and parasitic lineage

Frontiers in Ecology and Evolution
Endosymbiotic organelles, such as mitochondria and plastids, contain own remnant genomes (nucleoids), whose variable abundance in cells may be adaptive to the physiological necessities and functions of the cells.
Tim Brandler, N. Chakarov
semanticscholar   +1 more source

Drug targets in the apicoplast of malaria parasites [PDF]

, 2017
© 2017 Dr. Taher UddinHuman malaria is caused by six species of Plasmodium, and despite considerable effort, it remains as one of the deadliest of infectious diseases. African children under the age of five are the most vulnerable population. Drugs are
Uddin, Taher
core  

Cryo-electron tomography reveals four-membrane architecture of the Plasmodium apicoplast [PDF]

, 2013
The apicoplast is a plastid organelle derived from a secondary endosymbiosis, containing biosynthetic pathways essential for the survival of apicomplexan parasites. The Toxoplasma apicoplast clearly possesses four membranes but in related Plasmodium spp.
Kudryashev, M, Riglar, DT, Kudryashev, M., David T Riglar, Baum, J., Riglar, D.T., Frischknecht, F., Riglar, David T, Lemgruber, L., Ralph, S.A., Stahlberg, Henning, Dekiwadia, C., Stahlberg, H, Frischknecht, Friedrich, Baum, Jake, Jake Baum, Dekiwadia, Chaitali, Kudryashev, M. ; https://orcid.org/, Kudryashev, Mikhail, Lemgruber, L, Lemgruber, Leandro, Mikhail Kudryashev, Chaitali Dekiwadia, Riglar, David T., Ralph, Stuart A., Frischknecht, F, Leandro Lemgruber, Lemgruber Soares, Leandro, Ralph, S., Stahlberg, H., Dekiwadia, C, Ralph, Stuart A, Stuart A Ralph, Henning Stahlberg, Riglar, D., Friedrich Frischknecht, Baum, J, Ralph, SA   +37 more
core   +1 more source

tRNA modifying enzymes MnmE and MnmG are essential for Plasmodium falciparum apicoplast maintenance

bioRxiv
The circular genome of the Plasmodium falciparum apicoplast contains a complete minimal set of tRNAs, positioning the apicoplast as an ideal model for studying the fundamental factors required for protein translation.
Rubayet Elahi, Luciana Ribeiro Dinis, Russell P. Swift, Hans B. Liu, S. Prigge   +4 more
semanticscholar   +1 more source

The apicoplast: a red alga in human parasites [PDF]

Essays in Biochemistry, 2011
Surprisingly, some of the world's most dangerous parasites appear to have had a benign photosynthetic past in the ocean. The phylum Apicomplexa includes the causative agents of malaria and a number of additional human and animal diseases. These diseases threaten the life and health of hundreds of millions each year and pose a tremendous challenge to ...
openaire   +2 more sources

Models for apicoplast evolutionary history and lumenal protein import.

, 2019
(A) Model for apicoplast evolutionary history. Red algae arose following primary endosymbiosis, during which a eukaryotic cell engulfed a photosynthetic cyanobacterium that underwent evolutionary reduction to become a chloroplast.
Ellen Yeh (207853), Michael J. Boucher (5745728)   +1 more
core   +1 more source