Biomolecules, 2019 The phylum Apicomplexa (Alveolates) comprises a group of host-associated protists, predominately intracellular parasites, including devastating parasites like Plasmodium falciparum, the causative agent of malaria.
Eric D. Salomaki, Martin Kolisko
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Selective inhibition of apicoplast tryptophanyl-tRNA synthetase causes delayed death in Plasmodium falciparum [PDF]
, 2016 The malaria parasite Plasmodium falciparum relies on efficient protein translation. An essential component of translation is the tryptophanyl-tRNA synthetase (TrpRS) that charges tRNA(trp).
Cheung, Vanessa +13 more
core +1 more source
Small molecule inhibition of apicomplexan FtsH1 disrupts plastid biogenesis in human pathogens
eLife, 2017 The malaria parasite Plasmodium falciparum and related apicomplexan pathogens contain an essential plastid organelle, the apicoplast, which is a key anti-parasitic target. Derived from secondary endosymbiosis, the apicoplast depends on novel, but largely
Katherine Amberg-Johnson +6 more
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The Algal Past and Parasite Present of the Apicoplast
Annual Review of Microbiology, 2013 Plasmodium and Toxoplasma are genera of apicomplexan parasites that infect millions of people each year. The former causes malaria, and the latter causes neurotropic infections associated with a weakened or developing immune system. These parasites harbor a peculiar organelle, the apicoplast.
van Dooren, Giel, Striepen, Boris
openaire +3 more sources
The apicoplast localized isocitrate dehydrogenase is needed for <i>de novo</i> fatty acid synthesis in the apicoplast of <i>Toxoplasma gondii</i>. [PDF]
Front Cell Infect MicrobiolToxoplasma gondii (T. gondii), an apicomplexan parasite, infects a wide range of warm-blooded animals and poses significant risks to human health. The fatty acid synthesis II (FASII) pathway in the apicoplast, which is the major source of fatty acids in parasites, is considered a potential drug target.
Pan K +6 more
europepmc +4 more sources
Toxoplasma gondii devoid of an apicoplast
Several medically relevant Apicomplexa critically rely on the apicoplast, a remnant plastid organelle derived from secondary endosymbiosis. The apicoplast has lost its photosynthetic function but harbors essential metabolic pathways.
Maco, Bohumil +6 more
core +1 more source
Models for apicoplast evolutionary history and lumenal protein import.
, 2019 (A) Model for apicoplast evolutionary history. Red algae arose following primary endosymbiosis, during which a eukaryotic cell engulfed a photosynthetic cyanobacterium that underwent evolutionary reduction to become a chloroplast.
Ellen Yeh (207853) +1 more
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Autophagy-Related Protein ATG18 Regulates Apicoplast Biogenesis in Apicomplexan Parasites
mBio, 2017 Mechanisms by which 3′-phosphorylated phosphoinositides (3′-PIPs) regulate the development of apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii are poorly understood.
Priyanka Bansal +4 more
doaj +1 more source
Cryo-electron tomography reveals four-membrane architecture of the Plasmodium apicoplast [PDF]
, 2013 The apicoplast is a plastid organelle derived from a secondary endosymbiosis, containing biosynthetic pathways essential for the survival of apicomplexan parasites. The Toxoplasma apicoplast clearly possesses four membranes but in related Plasmodium spp.
Kudryashev, M +37 more
core +1 more source
Disruption of the Suf pathway leads to apicoplast loss.
, 2013 The Isc pathway is located in the mitochondrion while the Suf pathway is located in the apicoplast. The exclusive division of the two pathways between the two endosymbiont organelles suggests that the FeS-dependent proteins the apicoplast rely solely on ...
Krista A. Matthews (463664) +4 more
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