Results 81 to 90 of about 17,169 (224)
Comparative analysis of apicoplast genomes of Babesia infective to small ruminants in China
Parasites & Vectors, 2019 Background Babesiosis is an economically important disease caused by tick-borne apicomplexan protists of the genus Babesia. Most apicomplexan parasites, including Babesia, have a plastid-derived organelle termed an apicoplast, which is involved in ...
Xiaoxing Wang +11 more
doaj +1 more source
eLife, 2020 The apicoplast of Plasmodium falciparum parasites is believed to rely on the import of three-carbon phosphate compounds for use in organelle anabolic pathways, in addition to the generation of energy and reducing power within the organelle.
Russell P Swift +7 more
doaj +1 more source
Integrative Zoology, Volume 21, Issue 1, Page 137-150, January 2026.This study identifies Polychromophilus sp. in blood‐feeding flies (Basilia speiseri and Basilia lindolphoi) from Myotis nigricans bats in Brazil, marking the first molecular detection of the parasite in an insect vector in this country. Two haplotypes were identified, both within the Polychromophilus murinus group.
Bruno S. Mathias +7 more
wiley +1 more source
Evolutionary Pressures on Apicoplast Transit Peptides [PDF]
Molecular Biology and Evolution, 2004 Malaria parasites (species of the genus Plasmodium) harbor a relict chloroplast (the apicoplast) that is the target of novel antimalarials. Numerous nuclear-encoded proteins are translocated into the apicoplast courtesy of a bipartite N-terminal extension.
Stuart A, Ralph +3 more
openaire +2 more sources
Colocalization of Atg8 and the apicoplast.
, 2014 The indicated stages of P. falciparum D10 parasites expressing the apicoplast marker ACP-GFP were evaluated for colocalization of PfAtg8 with the apicoplast as described in Materials and Methods section.
Atul (113444) +3 more
core +1 more source
Generation and characterization of an apicoplast-disrupted PfMev parasite line.
, 2020 A) Attempted detection of nuclear, mitochondrial, and apicoplast genomes by PCR amplification of the genes ldh (nuclear, N), sufB (apicoplast, A), and cox1 (mitochondrial, M) from PfMev parasites treated with 100nM azithromycin and 50μM mevalonate for ...
Hans B. Liu (8452467) +11 more
core +1 more source
Gene Expression, Docking and Machine Learning in Malaria Drug Discovery: A Systematic Review
Biochemistry Research International, Volume 2026, Issue 1, 2026.Background Malaria remains a significant and worldwide health threat with increasing resistance to current treatments, stimulating the demand for innovative approaches in pursuing drug discovery. This systematic review integrates the progress made from 2014 through 2024 regarding molecular methods like gene expression profiling, molecular docking and ...
Reuben Samson Dangana +5 more
wiley +1 more source
A systematic screen to discover and analyze apicoplast proteins identifies a conserved and essential protein import factor. [PDF]
PLoS Pathogens, 2011 Parasites of the phylum Apicomplexa cause diseases that impact global health and economy. These unicellular eukaryotes possess a relict plastid, the apicoplast, which is an essential organelle and a validated drug target.
Lilach Sheiner +7 more
doaj +1 more source
Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.The emergence of infectious diseases associated with land‐use changes is well‐documented. However, the presence and dynamics of zoonotic pathogens in small mammals within European forests, whether from rural development or urban greening, remain underexplored.
Marie Bouilloud +15 more
wiley +1 more source
Reduced ribosomes of the apicoplast and mitochondrion of Plasmodium spp. and predicted interactions with antibiotics [PDF]
Open Biology, 2014 Apicomplexan protists such as Plasmodium and Toxoplasma contain a mitochondrion and a relic plastid (apicoplast) that are sites of protein translation.
Ankit Gupta +6 more
doaj +1 more source