Results 81 to 90 of about 16,726 (193)

The apicoplast transportome of the malaria parasite

Trends in Parasitology
The apicoplast, a peculiar organelle of red algal origin surrounded by four membranes, is important for several metabolic processes in the malaria parasite, including isopentenyl pyrophosphate (IPP) and coenzyme A (CoA) biosynthesis. Transporters are required to provide substrates and export products for these metabolic pathways and are therefore ...
Laura J. Akkerman, Taco W.A. Kooij, Laura E. de Vries   +2 more
openaire   +4 more sources

Dissecting apicoplast functions through continuous cultivation of Toxoplasma gondii devoid of the organelle

Nature Communications
The apicoplast, a relic plastid organelle derived from secondary endosymbiosis, is crucial for many medically relevant Apicomplexa. While it no longer performs photosynthesis, the organelle retains several essential metabolic pathways.
Min Chen, Szilamér Gyula Koszti, Alessandro Bonavoglia, Bohumil Maco, Olivier von Rohr, Hong-Juan Peng, Dominique Soldati-Favre, Joachim Kloehn   +7 more
doaj   +1 more source

Tandem Mass Spectrometry and Bio‐Guided Isolation of Secondary Metabolites With Antiplasmodial Activity From Dalbergia miscolobium Bark

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
ABSTRACT Strategies have been employed to address antimalarial drug resistance, including the exploration of new therapeutic targets. In this study, the stem bark of Dalbergia miscolobium was investigated using in vitro assays against Plasmodium falciparum and pyruvate kinase II (PyrKII), an essential enzyme for parasite development.
Thais Bertolino Vieira Dantas, Igor M. R. Moura, Romário Pereira da Costa, Guilherme Eduardo de Souza, Richele Priscila Severino, Hélder Nagai Consolaro, Luis Felipe de Oliveira, Vinicius Bonatto, Quezia Bezerra Cass, Rafael V. C. Guido, Lorena Ramos Freitas de Sousa   +10 more
wiley   +1 more source

Generation and characterization of an apicoplast-disrupted PfMev parasite line.

, 2020
A) Attempted detection of nuclear, mitochondrial, and apicoplast genomes by PCR amplification of the genes ldh (nuclear, N), sufB (apicoplast, A), and cox1 (mitochondrial, M) from PfMev parasites treated with 100nM azithromycin and 50μM mevalonate for ...
Hans B. Liu (8452467), Anders Wallqvist (43485), Shivendra G. Tewari (8452482), Amanda Dziedzic (2549350), Russell P. Swift (8452464), Sean T. Prigge (370088), Namandje N. Bumpus (8452479), Krithika Rajaram (3350864), Hugo Jhun (8153199), Krista A. Matthews (8452476), Anne E. Jedlicka (8452470), Aleah D. Roberts (8452473)   +11 more
core   +1 more source

Highly divergent apicomplexan cytoskeletons provide additional models for actin biology

The FEBS Journal, Volume 292, Issue 24, Page 6459-6480, December 2025.
Actin is a highly conserved, abundant and central molecule in eukaryotes. Apicomplexans contain some of the most sequence‐divergent actin cytoskeletons known. This divergence results in overlapping yet different biochemical properties. Here, we highlight the remarkable divergence of the actin cytoskeleton by comparing apicomplexan to classical systems,
Yukino Kobayashi, Ross G. Douglas
wiley   +1 more source

The apicoplast: a red alga in human parasites [PDF]

Essays in Biochemistry, 2011
Surprisingly, some of the world's most dangerous parasites appear to have had a benign photosynthetic past in the ocean. The phylum Apicomplexa includes the causative agents of malaria and a number of additional human and animal diseases. These diseases threaten the life and health of hundreds of millions each year and pose a tremendous challenge to ...
openaire   +2 more sources

Ultrastructure of the Endoplasmic Reticulum in Eukaryotic Microalgae

Journal of Eukaryotic Microbiology, Volume 72, Issue 5, September/October 2025.
ABSTRACT The endoplasmic reticulum (ER) is a large and highly dynamic component of the eukaryotic endomembrane system. In eukaryotic microalgae, it plays six distinct roles: (1) It envelopes the chromatin to form the nucleus. (2) It forms cisternae in the cytoplasm, some of which scaffold the synthesis of proteins destined for incorporation into ...
Ursula Goodenough, Robyn Roth
wiley   +1 more source

Drug targets in the apicoplast of malaria parasites [PDF]

, 2017
© 2017 Dr. Taher UddinHuman malaria is caused by six species of Plasmodium, and despite considerable effort, it remains as one of the deadliest of infectious diseases. African children under the age of five are the most vulnerable population. Drugs are
Uddin, Taher
core   +1 more source

Inheritance of the genome-less apicoplast in the “apicoplast-minus” Plasmodium falciparum

Abstract Most apicomplexan parasites contain a plastid-derived organelle called the apicoplast, which originated through secondary endosymbiosis. As a result of this evolutionary trajectory, the non-photosynthetic apicoplast is surrounded by four membranes and contains many bacterial-like, druggable targets.
Xu, Wei, Nwankwo, Ikechukwu, Prigge, Sean T., Ke, Hangjun   +3 more
openaire   +2 more sources

Plasmodium apicoplast tyrosyl-tRNA synthetase recognizes an unusual, simplified identity set in cognate tRNATyr.

PLoS ONE, 2018
The life cycle of Plasmodium falciparum, the agent responsible for malaria, depends on both cytosolic and apicoplast translation fidelity. Apicoplast aminoacyl-tRNA synthetases (aaRS) are bacterial-like enzymes devoted to organellar tRNA aminoacylation ...
Marta Cela, Caroline Paulus, Manuel A S Santos, Gabriela R Moura, Magali Frugier, Joëlle Rudinger-Thirion   +5 more
doaj   +1 more source