Results 61 to 70 of about 16,726 (193)
Plant Direct, Volume 10, Issue 2, February 2026.ABSTRACT Chaperones are essential for facilitating the import of nuclear‐encoded precursor proteins into chloroplasts. In the intermembrane space (IMS) of the chloroplasts, this process is mediated by the transport‐associated domains (POTRA) of the translocon at the outer envelope membrane (Toc75) and translocon at the inner envelope membrane (Tic22 ...
Rajneesh Singhal, Danny J. Schnell
wiley +1 more source
PLoS ONE, 2014 Malaria parasites retain a relict plastid (apicoplast) from a photosynthetic ancestor shared with dinoflagellate algae. The apicoplast is a useful drug target; blocking housekeeping pathways such as genome replication and translation in the organelle ...
Christopher D Goodman +1 more
doaj +1 more source
Roles of Ferredoxin-Dependent Proteins in the Apicoplast of Plasmodium falciparum Parasites
mBio, 2022 Ferredoxin (Fd) and ferredoxin-NADP+ reductase (FNR) form a redox system that is hypothesized to play a central role in the maintenance and function of the apicoplast organelle of malaria parasites.
Russell P. Swift +4 more
doaj +1 more source
Imaging malaria parasites across scales and time
Journal of Microscopy, Volume 301, Issue 2, Page 122-150, February 2026.Abstract The idea that disease is caused at the cellular level is so fundamental to us that we might forget the critical role microscopy played in generating and developing this insight. Visually identifying diseased or infected cells lays the foundation for any effort to curb human pathology.
Julien Guizetti
wiley +1 more source
Journal of Microscopy, Volume 301, Issue 2, Page 168-186, February 2026.Abstract Malaria is one of the deadliest infectious diseases in the world, annually responsible for over 400,000 deaths. It is caused by parasites of the genus Plasmodium, which undergo remarkable structural changes during their development within different cells across various hosts.
Rachel Rachid +3 more
wiley +1 more source
Transcriptomic analysis of apicoplast-disrupted parasites.
, 2020 A) Hierarchical clustering of apicoplast genome expression from control and apicoplast-disrupted parasites during the IDC. The apicoplast gene expression data were normalized by the median expression of 5851 genes from corresponding parasites at each ...
Hans B. Liu (8452467) +11 more
core +1 more source
FEBS Letters, Volume 600, Issue 2, Page 251-266, January 2026.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
Evolutionary Pressures on Apicoplast Transit Peptides [PDF]
Molecular Biology and Evolution, 2004 Malaria parasites (species of the genus Plasmodium) harbor a relict chloroplast (the apicoplast) that is the target of novel antimalarials. Numerous nuclear-encoded proteins are translocated into the apicoplast courtesy of a bipartite N-terminal extension.
Stuart A, Ralph +3 more
openaire +2 more sources
Comparative analysis of apicoplast genomes of Babesia infective to small ruminants in China
Parasites & Vectors, 2019 Background Babesiosis is an economically important disease caused by tick-borne apicomplexan protists of the genus Babesia. Most apicomplexan parasites, including Babesia, have a plastid-derived organelle termed an apicoplast, which is involved in ...
Xiaoxing Wang +11 more
doaj +1 more source
eLife, 2020 The apicoplast of Plasmodium falciparum parasites is believed to rely on the import of three-carbon phosphate compounds for use in organelle anabolic pathways, in addition to the generation of energy and reducing power within the organelle.
Russell P Swift +7 more
doaj +1 more source