Results 61 to 70 of about 14,891 (174)

Antimalarial Potential of Synthetic Geraniol and Nerol Analogs

Journal of Chemistry, Volume 2026, Issue 1, 2026.
Drug resistance is a major threat to malaria control; therefore, new drugs are required to combat this parasitosis. To accelerate drug development, the exploration of natural compounds or the repositioning of drugs already employed for other diseases is of particular interest.
Maurício Mazzine Filho, Isaac Agnelo Da Silva Sobreiro, Gabriel Dos Santos E. Silva, Carlos Alberto De Araújo Silva, Leonardo Vinícius Nogueira Lima, Arthur Vicentini Furtado, João Vitor Da Silveira, Marcus Vinícius Nora De Souza, Matheus Felipe Silva Santos, Gabriela Oliveira Castro, Manoel Aparecido Peres, Marcell Crispim, Alejandro Miguel Katzin, Mauricio Frota Saraiva, Ignasi Bofill Verdaguer, Munmun Bardhan   +15 more
wiley   +1 more source

Surveillance of Zoonotic Pathogens in Small Mammals Across Forests With Different Levels of Anthropization in Eastern France

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
The emergence of infectious diseases associated with land‐use changes is well‐documented. However, the presence and dynamics of zoonotic pathogens in small mammals within European forests, whether from rural development or urban greening, remain underexplored.
Marie Bouilloud, Maxime Galan, Anaïs Bordes, Caroline Tatard, Philippe Gauthier, Julien Pradel, Guillaume Castel, Hussein Alburkat, Lara Dutra, Tarja Sironen, Clémence Galon, Sara Moutailler, Zorée Djelouadji, Benjamin Roche, Nathalie Charbonnel, Javier Millán   +15 more
wiley   +1 more source

Reduced ribosomes of the apicoplast and mitochondrion of Plasmodium spp. and predicted interactions with antibiotics [PDF]

Open Biology, 2014
Apicomplexan protists such as Plasmodium and Toxoplasma contain a mitochondrion and a relic plastid (apicoplast) that are sites of protein translation.
Ankit Gupta, Priyanka Shah, Afreen Haider, Kirti Gupta, Mohammad Imran Siddiqi, Stuart A. Ralph, Saman Habib   +6 more
doaj   +1 more source

The apicoplast transportome of the malaria parasite

Trends in Parasitology
The apicoplast, a peculiar organelle of red algal origin surrounded by four membranes, is important for several metabolic processes in the malaria parasite, including isopentenyl pyrophosphate (IPP) and coenzyme A (CoA) biosynthesis. Transporters are required to provide substrates and export products for these metabolic pathways and are therefore ...
Laura J. Akkerman, Taco W.A. Kooij, Laura E. de Vries   +2 more
openaire   +4 more sources

A Novel Antimalarial Agent that Inhibits Protein Synthesis in Plasmodium falciparum

Angewandte Chemie International Edition, Volume 64, Issue 49, December 1, 2025.
Compound 31 represents a promising avenue for the development as an antimalarial agent with a potent activity profile (PfNF54 IC50 ± s.d. = 3.9 ± 0.4 nM). It has a novel mode of action by binding to cytosolic ribosomal subunits, thereby inhibiting protein synthesis in the parasite.
Patricia Bravo, Eleonora Diamanti, Mostafa M. Hamed, Lorenzo Bizzarri, Natalie Wiedemar, Armin Passecker, Nicolas M. B. Brancucci, Anna Albisetti, Christin Gumpp, Boris Illarionov, Markus Fischer, Matthias Witschel, Tobias Schehl, Hannes Hahne, Pascal Mäser, Matthias Rottmann, Anna K. H. Hirsch   +16 more
wiley   +1 more source

Tandem Mass Spectrometry and Bio‐Guided Isolation of Secondary Metabolites With Antiplasmodial Activity From Dalbergia miscolobium Bark

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
ABSTRACT Strategies have been employed to address antimalarial drug resistance, including the exploration of new therapeutic targets. In this study, the stem bark of Dalbergia miscolobium was investigated using in vitro assays against Plasmodium falciparum and pyruvate kinase II (PyrKII), an essential enzyme for parasite development.
Thais Bertolino Vieira Dantas, Igor M. R. Moura, Romário Pereira da Costa, Guilherme Eduardo de Souza, Richele Priscila Severino, Hélder Nagai Consolaro, Luis Felipe de Oliveira, Vinicius Bonatto, Quezia Bezerra Cass, Rafael V. C. Guido, Lorena Ramos Freitas de Sousa   +10 more
wiley   +1 more source

The Algal Past and Parasite Present of the Apicoplast

Annual Review of Microbiology, 2013
Plasmodium and Toxoplasma are genera of apicomplexan parasites that infect millions of people each year. The former causes malaria, and the latter causes neurotropic infections associated with a weakened or developing immune system. These parasites harbor a peculiar organelle, the apicoplast.
van Dooren, Giel, Striepen, Boris
openaire   +3 more sources

Highly divergent apicomplexan cytoskeletons provide additional models for actin biology

The FEBS Journal, Volume 292, Issue 24, Page 6459-6480, December 2025.
Actin is a highly conserved, abundant and central molecule in eukaryotes. Apicomplexans contain some of the most sequence‐divergent actin cytoskeletons known. This divergence results in overlapping yet different biochemical properties. Here, we highlight the remarkable divergence of the actin cytoskeleton by comparing apicomplexan to classical systems,
Yukino Kobayashi, Ross G. Douglas
wiley   +1 more source

A mutagenesis screen for essential plastid biogenesis genes in human malaria parasites.

PLoS Biology, 2019
Endosymbiosis has driven major molecular and cellular innovations. Plasmodium spp. parasites that cause malaria contain an essential, non-photosynthetic plastid-the apicoplast-which originated from a secondary (eukaryote-eukaryote) endosymbiosis.
Yong Tang, Thomas R Meister, Marta Walczak, Michael J Pulkoski-Gross, Sanjay B Hari, Robert T Sauer, Katherine Amberg-Johnson, Ellen Yeh   +7 more
doaj   +1 more source

Ultrastructure of the Endoplasmic Reticulum in Eukaryotic Microalgae

Journal of Eukaryotic Microbiology, Volume 72, Issue 5, September/October 2025.
ABSTRACT The endoplasmic reticulum (ER) is a large and highly dynamic component of the eukaryotic endomembrane system. In eukaryotic microalgae, it plays six distinct roles: (1) It envelopes the chromatin to form the nucleus. (2) It forms cisternae in the cytoplasm, some of which scaffold the synthesis of proteins destined for incorporation into ...
Ursula Goodenough, Robyn Roth
wiley   +1 more source