Results 51 to 60 of about 14,891 (174)

Ycf93 (Orf105), a small apicoplast-encoded membrane protein in the relict plastid of the malaria parasite Plasmodium falciparum that is conserved in Apicomplexa.

PLoS ONE, 2014
Malaria parasites retain a relict plastid (apicoplast) from a photosynthetic ancestor shared with dinoflagellate algae. The apicoplast is a useful drug target; blocking housekeeping pathways such as genome replication and translation in the organelle ...
Christopher D Goodman, Geoffrey I McFadden   +1 more
doaj   +1 more source

Roles of Ferredoxin-Dependent Proteins in the Apicoplast of Plasmodium falciparum Parasites

mBio, 2022
Ferredoxin (Fd) and ferredoxin-NADP+ reductase (FNR) form a redox system that is hypothesized to play a central role in the maintenance and function of the apicoplast organelle of malaria parasites.
Russell P. Swift, Krithika Rajaram, Rubayet Elahi, Hans B. Liu, Sean T. Prigge   +4 more
doaj   +1 more source

Optimisation of freeze substitution protocols for the examination of malaria parasite structure by volumetric electron microscopy

Journal of Microscopy, Volume 301, Issue 2, Page 168-186, February 2026.
Abstract Malaria is one of the deadliest infectious diseases in the world, annually responsible for over 400,000 deaths. It is caused by parasites of the genus Plasmodium, which undergo remarkable structural changes during their development within different cells across various hosts.
Rachel Rachid, Camila Wendt, Wanderley de Souza, Kildare Miranda   +3 more
wiley   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, Volume 600, Issue 2, Page 251-266, January 2026.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Evolutionary Pressures on Apicoplast Transit Peptides [PDF]

Molecular Biology and Evolution, 2004
Malaria parasites (species of the genus Plasmodium) harbor a relict chloroplast (the apicoplast) that is the target of novel antimalarials. Numerous nuclear-encoded proteins are translocated into the apicoplast courtesy of a bipartite N-terminal extension.
Stuart A, Ralph, Bernardo J, Foth, Neil, Hall, Geoffrey I, McFadden   +3 more
openaire   +2 more sources

Comparative analysis of apicoplast genomes of Babesia infective to small ruminants in China

Parasites & Vectors, 2019
Background Babesiosis is an economically important disease caused by tick-borne apicomplexan protists of the genus Babesia. Most apicomplexan parasites, including Babesia, have a plastid-derived organelle termed an apicoplast, which is involved in ...
Xiaoxing Wang, Jinming Wang, Junlong Liu, Aihong Liu, Xin He, Jianlin Xu, Zhi Li, Shuaiyang Zhao, Youquan Li, Hong Yin, Jianxun Luo, Guiquan Guan   +11 more
doaj   +1 more source

The NTP generating activity of pyruvate kinase II is critical for apicoplast maintenance in Plasmodium falciparum

eLife, 2020
The apicoplast of Plasmodium falciparum parasites is believed to rely on the import of three-carbon phosphate compounds for use in organelle anabolic pathways, in addition to the generation of energy and reducing power within the organelle.
Russell P Swift, Krithika Rajaram, Cyrianne Keutcha, Hans B Liu, Bobby Kwan, Amanda Dziedzic, Anne E Jedlicka, Sean T Prigge   +7 more
doaj   +1 more source

Polychromophilus spp. (Haemosporida: Plasmodiidae): First Molecular Detection in Bat Flies From Brazilian Bats

Integrative Zoology, Volume 21, Issue 1, Page 137-150, January 2026.
This study identifies Polychromophilus sp. in blood‐feeding flies (Basilia speiseri and Basilia lindolphoi) from Myotis nigricans bats in Brazil, marking the first molecular detection of the parasite in an insect vector in this country. Two haplotypes were identified, both within the Polychromophilus murinus group.
Bruno S. Mathias, Vinicio R. De Lima, Gustavo Graciolli, Nubia R. M. F. Rocha, Jaciara O. J. Costa, Herbert S. Soares, Arlei Marcili, Karin Kirchgatter   +7 more
wiley   +1 more source

Gene Expression, Docking and Machine Learning in Malaria Drug Discovery: A Systematic Review

Biochemistry Research International, Volume 2026, Issue 1, 2026.
Background Malaria remains a significant and worldwide health threat with increasing resistance to current treatments, stimulating the demand for innovative approaches in pursuing drug discovery. This systematic review integrates the progress made from 2014 through 2024 regarding molecular methods like gene expression profiling, molecular docking and ...
Reuben Samson Dangana, Israel Ehizuelen Ebhohimen, Samson Anjikwi Malgwi, Samuel Chima Ugbaja, Moses Okpeku, Harleen Khatra   +5 more
wiley   +1 more source

A systematic screen to discover and analyze apicoplast proteins identifies a conserved and essential protein import factor. [PDF]

PLoS Pathogens, 2011
Parasites of the phylum Apicomplexa cause diseases that impact global health and economy. These unicellular eukaryotes possess a relict plastid, the apicoplast, which is an essential organelle and a validated drug target.
Lilach Sheiner, Jessica L Demerly, Nicole Poulsen, Wandy L Beatty, Olivier Lucas, Michael S Behnke, Michael W White, Boris Striepen   +7 more
doaj   +1 more source