Results 31 to 40 of about 14,891 (174)

Two apicoplast dwelling glycolytic enzymes provide key substrates for metabolic pathways in the apicoplast and are critical for Toxoplasma growth.

PLoS Pathogens, 2022
Many apicomplexan parasites harbor a non-photosynthetic plastid called the apicoplast, which hosts important metabolic pathways like the methylerythritol 4-phosphate (MEP) pathway that synthesizes isoprenoid precursors.
Zhipeng Niu, Shu Ye, Jiaojiao Liu, Mengyu Lyu, Lilan Xue, Muxiao Li, Congcong Lyu, Junlong Zhao, Bang Shen   +8 more
doaj   +1 more source

A Plastid Protein That Evolved from Ubiquitin and Is Required for Apicoplast Protein Import in Toxoplasma gondii

mBio, 2017
Apicomplexan parasites cause a variety of important infectious diseases, including malaria, toxoplasma encephalitis, and severe diarrhea due to Cryptosporidium.
Justin D. Fellows, Michael J. Cipriano, Swati Agrawal, Boris Striepen   +3 more
doaj   +1 more source

A mevalonate bypass system facilitates elucidation of plastid biology in malaria parasites.

PLoS Pathogens, 2020
Malaria parasites rely on a plastid organelle for survival during the blood stages of infection. However, the entire organelle is dispensable as long as the isoprenoid precursor, isopentenyl pyrophosphate (IPP), is supplemented in the culture medium.
Russell P Swift, Krithika Rajaram, Hans B Liu, Amanda Dziedzic, Anne E Jedlicka, Aleah D Roberts, Krista A Matthews, Hugo Jhun, Namandje N Bumpus, Shivendra G Tewari, Anders Wallqvist, Sean T Prigge   +11 more
doaj   +1 more source

Characterization and annotation of Babesia orientalis apicoplast genome

Parasites & Vectors, 2015
Background Babesia orientalis is an obligate intraerythrocytic protozoan parasite of the buffalo (Bubalus bubalis, Linnaeus, 1758) transmitted by the tick Rhipicephalus heamaphysaloides.
Yuan Huang, Lan He, Jinfang Hu, Pei He, Junwei He, Long Yu, Ngabu Malobi, Yanqin Zhou, Bang Shen, JunLong Zhao   +9 more
doaj   +1 more source

The suf iron-sulfur cluster synthesis pathway is required for apicoplast maintenance in malaria parasites. [PDF]

PLoS Pathogens, 2013
The apicoplast organelle of the malaria parasite Plasmodium falciparum contains metabolic pathways critical for liver-stage and blood-stage development.
Jolyn E Gisselberg, Teegan A Dellibovi-Ragheb, Krista A Matthews, Gundula Bosch, Sean T Prigge   +4 more
doaj   +1 more source

Theileria Apicoplast as a Target for Chemotherapy [PDF]

Antimicrobial Agents and Chemotherapy, 2009
ABSTRACT Theileria parasites cause severe bovine disease and death in a large part of the world. These apicomplexan parasites possess a relic plastid (apicoplast), whose metabolic pathways include several promising drug targets.
Regina, Lizundia, Dirk, Werling, Gordon, Langsley, Stuart A, Ralph   +3 more
openaire   +2 more sources

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Phenotypical characterization of novel apicoplast membrane proteins in Toxoplasma gondii

One Health Advances
As a critical organelle in Toxoplasma gondii, an important zoonotic pathogen, the apicoplast plays a vital role in survival by hosting essential metabolic pathways.
Xiaowei Chen, Huiyong Ding, Hui Dong, De-Hua Lai, Geoff Hide, Xun Suo, Shaojun Long   +6 more
doaj   +1 more source

pr2‐Wormifier: A Bioinformatics Pipeline to Create Custom Reference Databases for Improved Metabarcoding of Marine Protists

Molecular Ecology Resources, Volume 26, Issue 5, July 2026.
ABSTRACT Metabarcoding of environmental and ancient environmental DNA (eDNA and sedaDNA) is a powerful approach for studying and monitoring marine communities. However, its effectiveness is limited by the availability of comprehensive and well‐curated reference databases, particularly for protists.
Stefanie Knell, Juliane Romahn, Miklós Bálint   +2 more
wiley   +1 more source

Discovery of Potent Antimalarial Agents Targeting Plasmodium falciparum DNA Gyrase B by Integrating Computational and Experimental Approaches

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
An integrated computational and experimental drug‐discovery approach identified UNC8153 as a potential novel scaffold active against drug‐sensitive and artemisinin‐resistant P. falciparum strains through inhibition of apicoplast PfGyrB. ABSTRACT The global spread of drug‐resistant Plasmodium falciparum, particularly artemisinin‐resistant strains ...
Biswajit Naik, Welka Sahu, Guneswar Sethi, Cherish Prashar, Gajendra Mohan Baldodiya, Jyoti Poswal, Chandi C. Mandal, Jeong Ho Hwang, Kailash C. Panday, K. Sony Reddy, Dhaneswar Prusty   +10 more
wiley   +1 more source