Results 31 to 40 of about 17,169 (224)

The Apicoplast as a Drug Target

, 2021
The apicoplast is a rudimentary plastid, non-photosynthetic, present in the majority of the Apicomplexan parasites with the exception of Cryptosporidium spp. and Gregarina spp., that may have lost the apicoplast during their evolution. Apicomplexan parasites are responsible for several life-threatening diseases with high economic importance in humans ...
Pun Pun, Bhabisha
openaire   +2 more sources

The dynamin-related protein PfDyn2 is essential for both apicoplast and mitochondrial fission in Plasmodium falciparum

mBio
Dynamins, or dynamin-related proteins (DRPs), are large mechano-sensitive GTPases that mediate membrane dynamics or organellar fission/fusion events. Plasmodium falciparum encodes three dynamin-like proteins whose functions are poorly understood.
Alexander A. Morano, Wei Xu, Francesca M. Navarro, Neeta Shadija, Jeffrey D. Dvorin, Hangjun Ke   +5 more
doaj   +2 more sources

Autophagy-Related Protein ATG18 Regulates Apicoplast Biogenesis in Apicomplexan Parasites

mBio, 2017
Mechanisms by which 3′-phosphorylated phosphoinositides (3′-PIPs) regulate the development of apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii are poorly understood.
Priyanka Bansal, Anuj Tripathi, Vandana Thakur, Asif Mohmmed, Pushkar Sharma   +4 more
doaj   +2 more sources

The Toxoplasma monocarboxylate transporters are involved in the metabolism within the apicoplast and are linked to parasite survival

eLife, 2023
The apicoplast is a four-membrane plastid found in the apicomplexans, which harbors biosynthesis and organelle housekeeping activities in the matrix. However, the mechanism driving the flux of metabolites, in and out, remains unknown.
Hui Dong, Jiong Yang, Kai He, Wen-Bin Zheng, De-Hua Lai, Jing Liu, Hui-Yong Ding, Rui-Bin Wu, Kevin M Brown, Geoff Hide, Zhao-Rong Lun, Xing-Quan Zhu, Shaojun Long   +12 more
doaj   +2 more sources

The apicoplast and mitochondrion of Toxoplasma gondii

, 2020
Toxoplasma gondii possesses two organelles derived by endosymbiosis, the mitochondrion, and a plastid-derived compartment called the apicoplast. Both organelles house are important metabolic pathways and are essential for the parasite.
Frank Seeber, Jean E. Feagin, Marilyn Parsons, Giel G. van Dooren   +3 more
openaire   +2 more sources

Critical role for isoprenoids in apicoplast biogenesis by malaria parasites

eLife, 2022
Isopentenyl pyrophosphate (IPP) is an essential metabolic output of the apicoplast organelle in Plasmodium falciparum malaria parasites and is required for prenylation-dependent vesicular trafficking and other cellular processes.
Megan Okada, Krithika Rajaram, Russell P Swift, Amanda Mixon, John Alan Maschek, Sean T Prigge, Paul A Sigala   +6 more
doaj   +1 more source

Vesicles bearing Toxoplasma apicoplast membrane proteins persist following loss of the relict plastid or Golgi body disruption. [PDF]

PLoS ONE, 2014
Toxoplasma gondii and malaria parasites contain a unique and essential relict plastid called the apicoplast. Most apicoplast proteins are encoded in the nucleus and are transported to the organelle via the endoplasmic reticulum (ER).
Anne Bouchut, Jennifer A Geiger, Amy E DeRocher, Marilyn Parsons   +3 more
doaj   +1 more source

A Major Facilitator Superfamily Transporter Is Critical for the Metabolism and Biogenesis of the Apicoplast. [PDF]

Pathogens
The apicoplast is a highly specialized organelle in the biosynthesis of essential metabolites in most of the apicomplexan protozoa. This organelle is surrounded by four layers of membranes.
Liang Y, Qi W, Fu J, Jia H.
europepmc   +2 more sources

The apicoplast localized isocitrate dehydrogenase is needed for <i>de novo</i> fatty acid synthesis in the apicoplast of <i>Toxoplasma gondii</i>. [PDF]

Front Cell Infect Microbiol
Toxoplasma gondii (T. gondii), an apicomplexan parasite, infects a wide range of warm-blooded animals and poses significant risks to human health. The fatty acid synthesis II (FASII) pathway in the apicoplast, which is the major source of fatty acids in ...
Pan K, Zeng A, Ruan X, Mo X, Shen B, Zhao J, Zhou Y.   +6 more
europepmc   +2 more sources

Decoding the Minimal Translation System of the Plasmodium falciparum Apicoplast: Essential tRNA-modifying Enzymes and Their Roles in Organelle Maintenance. [PDF]

J Mol Biol
Post-transcriptional tRNA modifications are essential for accurate and efficient protein translation across all organisms. The apicoplast organelle genome of Plasmodium falciparum contains a minimal set of 25 complete tRNA isotypes, making it an ideal ...
Elahi R, Mesones Mancilla S, Sievert ML, Ribeiro Dinis L, Adewale-Fasoro O, Mann A, Zur Y, Prigge ST.   +7 more
europepmc   +2 more sources