An apicoplast localized ubiquitylation system is required for the import of nuclear-encoded plastid proteins. [PDF]
PLoS Pathogens, 2013 Apicomplexan parasites are responsible for numerous important human diseases including toxoplasmosis, cryptosporidiosis, and most importantly malaria.
Swati Agrawal +10 more
doaj +1 more source
Cellular Hallmarks From Volume Electron Microscopy Reveal Developmental Progression of Plasmodium Ookinetes. [PDF]
Adv Sci (Weinh)This article presents a detailed ultrastructural cell atlas of Plasmodium ookinete development using advanced volume electron microscopy (v) techniques. It defines seven distinct developmental stages, revealing complex organelle interactions and offering new insights into parasite differentiation.
Darif N +12 more
europepmc +2 more sources
Cell Reports, 2017 Summary: The deadly malaria parasite Plasmodium falciparum contains a nonphotosynthetic plastid, known as the apicoplast, that functions to produce essential metabolites, and drugs that target the apicoplast are clinically effective.
Anat Florentin +7 more
doaj +1 more source
The Toxoplasma gondii Plastid replication and Repair Enzyme complex, PREX [PDF]
, 2009 A plastid-like organelle, the apicoplast, is essential to the majority of medically and veterinary important apicomplexan protozoa including Toxoplasma gondii and Plasmodium.
Chen, C-Y. +17 more
core +2 more sources
Doxycycline has distinct apicoplast-specific mechanisms of antimalarial activity
eLife, 2020 Doxycycline (DOX) is a key antimalarial drug thought to kill Plasmodium parasites by blocking protein translation in the essential apicoplast organelle. Clinical use is primarily limited to prophylaxis due to delayed second-cycle parasite death at 1–3 µM
Megan Okada +3 more
doaj +1 more source
Membrane and luminal proteins reach the apicoplast by different trafficking pathways in the malaria parasite Plasmodium falciparum [PDF]
PeerJ, 2017 The secretory pathway in Plasmodium falciparum has evolved to transport proteins to the host cell membrane and to an endosymbiotic organelle, the apicoplast. The latter can occur via the ER or the ER-Golgi route.
Rahul Chaudhari +4 more
doaj +2 more sources
Experimental Genetics of Plasmodium berghei NFU in the Apicoplast Iron-Sulfur Cluster Biogenesis Pathway. [PDF]
PLoS ONE, 2013 Eukaryotic pathogens of the phylum Apicomplexa contain a non-photosynthetic plastid, termed apicoplast. Within this organelle distinct iron-sulfur [Fe-S] cluster proteins are likely central to biosynthesis pathways, including generation of isoprenoids ...
Joana M Haussig +2 more
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mSphere, 2019 Malaria parasites (Plasmodium spp.) contain a nonphotosynthetic plastid organelle called the apicoplast, which houses essential metabolic pathways and is required throughout the parasite life cycle.
Michael J. Boucher, Ellen Yeh
doaj +1 more source
Annotation and characterization of Babesia gibsoni apicoplast genome
Parasites & Vectors, 2020 Background Babesia gibsoni is an apicomplexan parasite transmitted by ticks, which can infect canine species and cause babesiosis. The apicoplast is an organelle associated with isoprenoids metabolism, is widely present in apicomplexan parasites, except ...
Qin Liu +9 more
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The interdependence of isoprenoid synthesis and apicoplast biogenesis in malaria parasites.
PLoS Pathogens, 2023 Isoprenoid precursor synthesis is an ancient and fundamental function of plastid organelles and a critical metabolic activity of the apicoplast in Plasmodium malaria parasites [1-3].
Megan Okada, Paul A Sigala
doaj +1 more source