Results 11 to 20 of about 17,169 (224)

Phenotypical characterization of novel apicoplast membrane proteins in Toxoplasma gondii

One Health Advances
As a critical organelle in Toxoplasma gondii, an important zoonotic pathogen, the apicoplast plays a vital role in survival by hosting essential metabolic pathways.
Xiaowei Chen, Huiyong Ding, Hui Dong, De-Hua Lai, Geoff Hide, Xun Suo, Shaojun Long   +6 more
doaj   +3 more sources

Resistance to apicoplast translational inhibitors in Plasmodium. [PDF]

Int J Parasitol Drugs Drug Resist
The spread of drug-resistant Plasmodium threatens malaria control efforts. Thus, understanding the mechanisms of resistance is crucial for implementing effective treatments and prevention strategies. The prokaryote-like translational machinery encoded by the apicoplast is the apparent target of several antibiotics with antimalarial activity. Among them,
Home JL, McFadden GI, Goodman CD.
europepmc   +5 more sources

An apicoplast-localized deubiquitinase contributes to the cell growth and apicoplast homeostasis of Toxoplasma gondii

Veterinary Research
Toxoplasma gondii is among the most important parasites worldwide. The apicoplast is a unique organelle shared by all Apicomplexan protozoa.
Jie Xia, Yimin Yang, Xueqiu Chen, Kaiyue Song, Guangxu Ma, Yi Yang, Chaoqun Yao, Aifang Du   +7 more
doaj   +4 more sources

Phosphatidylinositol 3-monophosphate is involved in toxoplasma apicoplast biogenesis. [PDF]

PLoS Pathogens, 2011
Apicomplexan parasites cause devastating diseases including malaria and toxoplasmosis. They harbour a plastid-like, non-photosynthetic organelle of algal origin, the apicoplast, which fulfils critical functions for parasite survival.
Lina Tawk, Jean-François Dubremetz, Philippe Montcourrier, Gaëtan Chicanne, Fabrice Merezegue, Véronique Richard, Bernard Payrastre, Markus Meissner, Henri J Vial, Christian Roy, Kai Wengelnik, Maryse Lebrun   +11 more
doaj   +3 more sources

Targeting the apicoplast in malaria [PDF]

Biochemical Society Transactions, 2019
Abstract Malaria continues to be one of the leading causes of human mortality in the world, and the therapies available are insufficient for eradication. Severe malaria is caused by the apicomplexan parasite Plasmodium falciparum.
Biddau, Marco, Sheiner, Lilach
openaire   +3 more sources

The Toxoplasma Apicoplast Phosphate Translocator Links Cytosolic and Apicoplast Metabolism and Is Essential for Parasite Survival [PDF]

Cell Host & Microbe, 2010
Apicomplexa are unicellular eukaryotic pathogens that carry a vestigial algal endosymbiont, the apicoplast. The physiological function of the apicoplast and its integration into parasite metabolism remain poorly understood and at times controversial.
Brooks, Carrie F, Johnsen, Hanne, van Dooren, Giel, Muthalagi, Mani, Lin, San San, Bohne, Wolfgang, Fischer, Karsten, Striepen, Boris   +7 more
core   +6 more sources

Inheritance of the genome-less apicoplast in the “apicoplast-minus” Plasmodium falciparum

bioRxiv
Abstract Most apicomplexan parasites contain a plastid-derived organelle called the apicoplast, which originated through secondary endosymbiosis. As a result of this evolutionary trajectory, the non-photosynthetic apicoplast is surrounded by four membranes and contains many bacterial-like, druggable targets.
Xu, Wei, Nwankwo, Ikechukwu, Prigge, Sean T., Ke, Hangjun   +3 more
openaire   +3 more sources

Apicoplast Dynamics During Plasmodium Cell Cycle

Frontiers in Cellular and Infection Microbiology, 2022
The deadly malaria parasite, Plasmodium falciparum, contains a unique subcellular organelle termed the apicoplast, which is a clinically-proven antimalarial drug target.
Arwa Elaagip, Sabrina Absalon, Anat Florentin   +2 more
doaj   +2 more sources

Transcription of the apicoplast genome

Molecular and Biochemical Parasitology, 2016
Many members of the Apicomplexa contain a remnant chloroplast, known as an apicoplast. The apicoplast encodes numerous genes, and loss of the organelle is lethal. Here, we present a summary of what is known about apicoplast transcription. Unlike plant chloroplasts, there is a single RNA polymerase, and initial transcription is polycistronic.
Nisbet, R.E.R., McKenzie, J.L.
openaire   +5 more sources

Two apicoplast dwelling glycolytic enzymes provide key substrates for metabolic pathways in the apicoplast and are critical for Toxoplasma growth.

PLoS Pathogens, 2022
Many apicomplexan parasites harbor a non-photosynthetic plastid called the apicoplast, which hosts important metabolic pathways like the methylerythritol 4-phosphate (MEP) pathway that synthesizes isoprenoid precursors.
Zhipeng Niu, Shu Ye, Jiaojiao Liu, Mengyu Lyu, Lilan Xue, Muxiao Li, Congcong Lyu, Junlong Zhao, Bang Shen   +8 more
doaj   +2 more sources