Results 11 to 20 of about 16,726 (193)

Phosphatidylinositol 3-monophosphate is involved in toxoplasma apicoplast biogenesis. [PDF]

PLoS Pathogens, 2011
Apicomplexan parasites cause devastating diseases including malaria and toxoplasmosis. They harbour a plastid-like, non-photosynthetic organelle of algal origin, the apicoplast, which fulfils critical functions for parasite survival.
Lina Tawk, Jean-François Dubremetz, Philippe Montcourrier, Gaëtan Chicanne, Fabrice Merezegue, Véronique Richard, Bernard Payrastre, Markus Meissner, Henri J Vial, Christian Roy, Kai Wengelnik, Maryse Lebrun   +11 more
doaj   +3 more sources

Targeting the apicoplast in malaria [PDF]

Biochemical Society Transactions, 2019
Abstract Malaria continues to be one of the leading causes of human mortality in the world, and the therapies available are insufficient for eradication. Severe malaria is caused by the apicomplexan parasite Plasmodium falciparum.
Biddau, Marco, Sheiner, Lilach
openaire   +4 more sources

The Toxoplasma Apicoplast Phosphate Translocator Links Cytosolic and Apicoplast Metabolism and Is Essential for Parasite Survival [PDF]

Cell Host & Microbe, 2010
Apicomplexa are unicellular eukaryotic pathogens that carry a vestigial algal endosymbiont, the apicoplast. The physiological function of the apicoplast and its integration into parasite metabolism remain poorly understood and at times controversial.
Brooks, Carrie F, Johnsen, Hanne, van Dooren, Giel, Muthalagi, Mani, Lin, San San, Bohne, Wolfgang, Fischer, Karsten, Striepen, Boris   +7 more
core   +7 more sources

Phenotypical characterization of novel apicoplast membrane proteins in Toxoplasma gondii [PDF]

One Health Advances
As a critical organelle in Toxoplasma gondii, an important zoonotic pathogen, the apicoplast plays a vital role in survival by hosting essential metabolic pathways.
Xiaowei Chen, Huiyong Ding, Hui Dong, De-Hua Lai, Geoff Hide, Xun Suo, Shaojun Long   +6 more
doaj   +2 more sources

Transcription of the apicoplast genome [PDF]

Molecular and Biochemical Parasitology, 2016
Many members of the Apicomplexa contain a remnant chloroplast, known as an apicoplast. The apicoplast encodes numerous genes, and loss of the organelle is lethal. Here, we present a summary of what is known about apicoplast transcription. Unlike plant chloroplasts, there is a single RNA polymerase, and initial transcription is polycistronic.
Nisbet, R.E.R., McKenzie, J.L.
openaire   +5 more sources

Apicoplast Dynamics During Plasmodium Cell Cycle

Frontiers in Cellular and Infection Microbiology, 2022
The deadly malaria parasite, Plasmodium falciparum, contains a unique subcellular organelle termed the apicoplast, which is a clinically-proven antimalarial drug target.
Arwa Elaagip, Sabrina Absalon, Anat Florentin   +2 more
doaj   +2 more sources

An apicoplast-localized deubiquitinase contributes to the cell growth and apicoplast homeostasis of Toxoplasma gondii

Veterinary Research
Toxoplasma gondii is among the most important parasites worldwide. The apicoplast is a unique organelle shared by all Apicomplexan protozoa.
Jie Xia, Yimin Yang, Xueqiu Chen, Kaiyue Song, Guangxu Ma, Yi Yang, Chaoqun Yao, Aifang Du   +7 more
doaj   +3 more sources

Two apicoplast dwelling glycolytic enzymes provide key substrates for metabolic pathways in the apicoplast and are critical for Toxoplasma growth.

PLoS Pathogens, 2022
Many apicomplexan parasites harbor a non-photosynthetic plastid called the apicoplast, which hosts important metabolic pathways like the methylerythritol 4-phosphate (MEP) pathway that synthesizes isoprenoid precursors.
Zhipeng Niu, Shu Ye, Jiaojiao Liu, Mengyu Lyu, Lilan Xue, Muxiao Li, Congcong Lyu, Junlong Zhao, Bang Shen   +8 more
doaj   +2 more sources

Characterization and annotation of Babesia orientalis apicoplast genome [PDF]

Parasites & Vectors, 2015
Background Babesia orientalis is an obligate intraerythrocytic protozoan parasite of the buffalo (Bubalus bubalis, Linnaeus, 1758) transmitted by the tick Rhipicephalus heamaphysaloides.
Yuan Huang, Lan He, Jinfang Hu, Pei He, Junwei He, Long Yu, Ngabu Malobi, Yanqin Zhou, Bang Shen, JunLong Zhao   +9 more
doaj   +2 more sources

Apicoplast-Localized Lysophosphatidic Acid Precursor Assembly Is Required for Bulk Phospholipid Synthesis in Toxoplasma gondii and Relies on an Algal/Plant-Like Glycerol 3-Phosphate Acyltransferase.

PLoS Pathogens, 2016
Most apicomplexan parasites possess a non-photosynthetic plastid (the apicoplast), which harbors enzymes for a number of metabolic pathways, including a prokaryotic type II fatty acid synthesis (FASII) pathway.
Souad Amiar, James I MacRae, Damien L Callahan, David Dubois, Giel G van Dooren, Melanie J Shears, Marie-France Cesbron-Delauw, Eric Maréchal, Malcolm J McConville, Geoffrey I McFadden, Yoshiki Yamaryo-Botté, Cyrille Y Botté   +11 more
doaj   +2 more sources