Cellular Hallmarks From Volume Electron Microscopy Reveal Developmental Progression of Plasmodium Ookinetes. [PDF]
Adv Sci (Weinh)This article presents a detailed ultrastructural cell atlas of Plasmodium ookinete development using advanced volume electron microscopy (v) techniques. It defines seven distinct developmental stages, revealing complex organelle interactions and offering new insights into parasite differentiation.
Darif N +12 more
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Vesicles bearing Toxoplasma apicoplast membrane proteins persist following loss of the relict plastid or Golgi body disruption. [PDF]
PLoS ONE, 2014 Toxoplasma gondii and malaria parasites contain a unique and essential relict plastid called the apicoplast. Most apicoplast proteins are encoded in the nucleus and are transported to the organelle via the endoplasmic reticulum (ER).
Anne Bouchut +3 more
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Targeting the apicoplast in malaria [PDF]
Biochemical Society Transactions, 2019 Abstract Malaria continues to be one of the leading causes of human mortality in the world, and the therapies available are insufficient for eradication. Severe malaria is caused by the apicomplexan parasite Plasmodium falciparum.
Biddau, Marco, Sheiner, Lilach
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Phosphatidylinositol 3-monophosphate is involved in toxoplasma apicoplast biogenesis. [PDF]
PLoS Pathogens, 2011 Apicomplexan parasites cause devastating diseases including malaria and toxoplasmosis. They harbour a plastid-like, non-photosynthetic organelle of algal origin, the apicoplast, which fulfils critical functions for parasite survival.
Lina Tawk +11 more
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An apicoplast localized ubiquitylation system is required for the import of nuclear-encoded plastid proteins. [PDF]
PLoS Pathogens, 2013 Apicomplexan parasites are responsible for numerous important human diseases including toxoplasmosis, cryptosporidiosis, and most importantly malaria.
Swati Agrawal +10 more
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Cell Reports, 2017 Summary: The deadly malaria parasite Plasmodium falciparum contains a nonphotosynthetic plastid, known as the apicoplast, that functions to produce essential metabolites, and drugs that target the apicoplast are clinically effective.
Anat Florentin +7 more
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Doxycycline has distinct apicoplast-specific mechanisms of antimalarial activity
eLife, 2020 Doxycycline (DOX) is a key antimalarial drug thought to kill Plasmodium parasites by blocking protein translation in the essential apicoplast organelle. Clinical use is primarily limited to prophylaxis due to delayed second-cycle parasite death at 1–3 µM
Megan Okada +3 more
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Membrane and luminal proteins reach the apicoplast by different trafficking pathways in the malaria parasite Plasmodium falciparum [PDF]
PeerJ, 2017 The secretory pathway in Plasmodium falciparum has evolved to transport proteins to the host cell membrane and to an endosymbiotic organelle, the apicoplast. The latter can occur via the ER or the ER-Golgi route.
Rahul Chaudhari +4 more
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Experimental Genetics of Plasmodium berghei NFU in the Apicoplast Iron-Sulfur Cluster Biogenesis Pathway. [PDF]
PLoS ONE, 2013 Eukaryotic pathogens of the phylum Apicomplexa contain a non-photosynthetic plastid, termed apicoplast. Within this organelle distinct iron-sulfur [Fe-S] cluster proteins are likely central to biosynthesis pathways, including generation of isoprenoids ...
Joana M Haussig +2 more
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Transcription of the apicoplast genome
Molecular and Biochemical Parasitology, 2016 Many members of the Apicomplexa contain a remnant chloroplast, known as an apicoplast. The apicoplast encodes numerous genes, and loss of the organelle is lethal. Here, we present a summary of what is known about apicoplast transcription. Unlike plant chloroplasts, there is a single RNA polymerase, and initial transcription is polycistronic.
Nisbet, R.E.R., McKenzie, J.L.
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