Results 21 to 30 of about 16,726 (193)

Resistance to apicoplast translational inhibitors in Plasmodium. [PDF]

Int J Parasitol Drugs Drug Resist
The spread of drug-resistant Plasmodium threatens malaria control efforts. Thus, understanding the mechanisms of resistance is crucial for implementing effective treatments and prevention strategies. The prokaryote-like translational machinery encoded by the apicoplast is the apparent target of several antibiotics with antimalarial activity. Among them,
Home JL, McFadden GI, Goodman CD.
europepmc   +4 more sources

The Apicoplast as a Drug Target

, 2021
The apicoplast is a rudimentary plastid, non-photosynthetic, present in the majority of the Apicomplexan parasites with the exception of Cryptosporidium spp. and Gregarina spp., that may have lost the apicoplast during their evolution. Apicomplexan parasites are responsible for several life-threatening diseases with high economic importance in humans ...
Pun Pun, Bhabisha
openaire   +2 more sources

Discovery of Potent Antimalarial Agents Targeting Plasmodium falciparum DNA Gyrase B by Integrating Computational and Experimental Approaches. [PDF]

Chem Biol Drug Des
An integrated computational and experimental drug‐discovery approach identified UNC8153 as a potential novel scaffold active against drug‐sensitive and artemisinin‐resistant P. falciparum strains through inhibition of apicoplast PfGyrB. ABSTRACT The global spread of drug‐resistant Plasmodium falciparum, particularly artemisinin‐resistant strains ...
Naik B, Sahu W, Sethi G, Prashar C, Baldodiya GM, Poswal J, Mandal CC, Hwang JH, Panday KC, Reddy KS, Prusty D.   +10 more
europepmc   +2 more sources

Experimental Approaches for Examining Apicoplast Biology

, 2019
Genetic manipulation is a powerful tool to study gene function but identifying the direct and primary functional outcomes of any gene depletion is crucial for this strategy to be productive. This is a major challenge for the study of apicoplast biology, because, in the absence of an efficient isolation method, apicoplast functions must be assayed in ...
Marco, Biddau, Jana, Ovciarikova, Lilach, Sheiner   +2 more
openaire   +3 more sources

Critical role for isoprenoids in apicoplast biogenesis by malaria parasites

eLife, 2022
Isopentenyl pyrophosphate (IPP) is an essential metabolic output of the apicoplast organelle in Plasmodium falciparum malaria parasites and is required for prenylation-dependent vesicular trafficking and other cellular processes.
Megan Okada, Krithika Rajaram, Russell P Swift, Amanda Mixon, John Alan Maschek, Sean T Prigge, Paul A Sigala   +6 more
doaj   +1 more source

The apicoplast and mitochondrion of Toxoplasma gondii

, 2020
Toxoplasma gondii possesses two organelles derived by endosymbiosis, the mitochondrion, and a plastid-derived compartment called the apicoplast. Both organelles house are important metabolic pathways and are essential for the parasite.
Frank Seeber, Jean E. Feagin, Marilyn Parsons, Giel G. van Dooren   +3 more
openaire   +2 more sources

Maternal inheritance and stage-specific variation of the apicoplast in Toxoplasma gondii during development in the intermediate and definitive host [PDF]

, 2005
The structure and location of Toxoplasma gondii apicoplasts were examined in intermediate and definitive hosts and shown to vary in a stage-specific manner.
Henriquez, F L, Muench, S P, Kirisits, M J, Ferguson, D J P, Prigge, S T, Rice, D W, Roberts, C W, McLeod, R L   +7 more
core   +4 more sources

Vesicles bearing Toxoplasma apicoplast membrane proteins persist following loss of the relict plastid or Golgi body disruption. [PDF]

PLoS ONE, 2014
Toxoplasma gondii and malaria parasites contain a unique and essential relict plastid called the apicoplast. Most apicoplast proteins are encoded in the nucleus and are transported to the organelle via the endoplasmic reticulum (ER).
Anne Bouchut, Jennifer A Geiger, Amy E DeRocher, Marilyn Parsons   +3 more
doaj   +1 more source

The Toxoplasma gondii plastid replication and repair enzyme complex, PREX [PDF]

, 2009
A plastid-like organelle, the apicoplast, is essential to the majority of medically and veterinary important apicomplexan protozoa including Toxoplasma gondii and Plasmodium.
Chen, C-Y., Mukhopadhyay, A, Roberts, C. W., Barrett, M. P., Henriquez, F. L., Doerig, C.   +5 more
core   +2 more sources

Apicoplast lipoic acid protein ligase B is not essential for Plasmodium falciparum [PDF]

, 2007
Lipoic acid (LA) is an essential cofactor of α-keto acid dehydrogenase complexes (KADHs) and the glycine cleavage system. In Plasmodium, LA is attached to the KADHs by organelle-specific lipoylation pathways.
Ryan Bissett, Carsten Wrenger, Gunther, M, Storm Janet, McMillan, Paul, Günther, S, Müller, S, Wallace, L., Muller, S., Patzewitz, Eva-Maria, Paul J McMillan, Lynsey Wallace, Wrenger, C., Günther, S., Bissett Ryan, Wrenger, Carsten, Smith, T.K., Muller, Sylke, McMillan Paul J, Bissett, Ryan, Guenther, Svenja, McMillan, Paul J., Smith, Terry, Sylke Müller, Patzewitz, E.-M., Terry K Smith, Storm, J., Günther Svenja, Storm, Janet, Svenja Günther, Patzewitz, EM, Wallace, Lynsey, Storm, J, McMillan, PJ, Patzewitz Eva-Maria, Mueller, Sylke, McMillan, P.J., Eva-Maria Patzewitz, Wallace Lynsey, Bissett, R, Wrenger, C, Janet Storm, Smith Terry K, Smith, TK, Wrenger Carsten, Smith, Terry K, Wallace, L, Bissett, R., Müller Sylke   +48 more
core   +1 more source