Results 21 to 30 of about 14,891 (174)

Disruption of Apicoplast Biogenesis by Chemical Stabilization of an Imported Protein Evades the Delayed-Death Phenotype in Malaria Parasites

mSphere, 2019
Malaria parasites (Plasmodium spp.) contain a nonphotosynthetic plastid organelle called the apicoplast, which houses essential metabolic pathways and is required throughout the parasite life cycle.
Michael J. Boucher, Ellen Yeh
doaj   +1 more source

Annotation and characterization of Babesia gibsoni apicoplast genome

Parasites & Vectors, 2020
Background Babesia gibsoni is an apicomplexan parasite transmitted by ticks, which can infect canine species and cause babesiosis. The apicoplast is an organelle associated with isoprenoids metabolism, is widely present in apicomplexan parasites, except ...
Qin Liu, Long Yu, Fan Jiang, Muxiao Li, Xueyan Zhan, Yuan Huang, Sen Wang, Xiaoyong Du, Lan He, Junlong Zhao   +9 more
doaj   +1 more source

ATG8 Is Essential Specifically for an Autophagy-Independent Function in Apicoplast Biogenesis in Blood-Stage Malaria Parasites

mBio, 2018
Plasmodium parasites and related pathogens contain an essential nonphotosynthetic plastid organelle, the apicoplast, derived from secondary endosymbiosis.
Marta Walczak, Suresh M. Ganesan, Jacquin C. Niles, Ellen Yeh   +3 more
doaj   +1 more source

Apicoplast Dynamics During Plasmodium Cell Cycle

Frontiers in Cellular and Infection Microbiology, 2022
The deadly malaria parasite, Plasmodium falciparum, contains a unique subcellular organelle termed the apicoplast, which is a clinically-proven antimalarial drug target.
Arwa Elaagip, Sabrina Absalon, Anat Florentin   +2 more
doaj   +1 more source

The interdependence of isoprenoid synthesis and apicoplast biogenesis in malaria parasites.

PLoS Pathogens, 2023
Isoprenoid precursor synthesis is an ancient and fundamental function of plastid organelles and a critical metabolic activity of the apicoplast in Plasmodium malaria parasites [1-3].
Megan Okada, Paul A Sigala
doaj   +1 more source

Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparum.

PLoS Biology, 2011
Plasmodium spp parasites harbor an unusual plastid organelle called the apicoplast. Due to its prokaryotic origin and essential function, the apicoplast is a key target for development of new anti-malarials. Over 500 proteins are predicted to localize to
Ellen Yeh, Joseph L DeRisi
doaj   +1 more source

The Toxoplasma Apicoplast Phosphate Translocator Links Cytosolic and Apicoplast Metabolism and Is Essential for Parasite Survival [PDF]

Cell Host & Microbe, 2010
Apicomplexa are unicellular eukaryotic pathogens that carry a vestigial algal endosymbiont, the apicoplast. The physiological function of the apicoplast and its integration into parasite metabolism remain poorly understood and at times controversial.
Brooks, Carrie F, Johnsen, Hanne, van Dooren, Giel, Muthalagi, Mani, Lin, San San, Bohne, Wolfgang, Fischer, Karsten, Striepen, Boris   +7 more
openaire   +4 more sources

Integrative proteomics and bioinformatic prediction enable a high-confidence apicoplast proteome in malaria parasites.

PLoS Biology, 2018
Malaria parasites (Plasmodium spp.) and related apicomplexan pathogens contain a nonphotosynthetic plastid called the apicoplast. Derived from an unusual secondary eukaryote-eukaryote endosymbiosis, the apicoplast is a fascinating organelle whose ...
Michael J Boucher, Sreejoyee Ghosh, Lichao Zhang, Avantika Lal, Se Won Jang, An Ju, Shuying Zhang, Xinzi Wang, Stuart A Ralph, James Zou, Joshua E Elias, Ellen Yeh   +11 more
doaj   +1 more source

CaaX-Like Protease of Cyanobacterial Origin Is Required for Complex Plastid Biogenesis in Malaria Parasites

mBio, 2020
Plasmodium parasites and related apicomplexans contain an essential “complex plastid” organelle of secondary endosymbiotic origin, the apicoplast. Biogenesis of this complex plastid poses a unique challenge requiring evolution of new cellular machinery ...
Thomas R. Meister, Yong Tang, Michael J. Pulkoski-Gross, Ellen Yeh   +3 more
doaj   +1 more source

Resistance to apicoplast translational inhibitors in Plasmodium. [PDF]

Int J Parasitol Drugs Drug Resist
The spread of drug-resistant Plasmodium threatens malaria control efforts. Thus, understanding the mechanisms of resistance is crucial for implementing effective treatments and prevention strategies. The prokaryote-like translational machinery encoded by the apicoplast is the apparent target of several antibiotics with antimalarial activity. Among them,
Home JL, McFadden GI, Goodman CD.
europepmc   +3 more sources