Results 21 to 30 of about 17,169 (224)

The apicoplast transportome of the malaria parasite

Trends in Parasitology
The apicoplast, a peculiar organelle of red algal origin surrounded by four membranes, is important for several metabolic processes in the malaria parasite, including isopentenyl pyrophosphate (IPP) and coenzyme A (CoA) biosynthesis. Transporters are required to provide substrates and export products for these metabolic pathways and are therefore ...
Laura J. Akkerman, Taco W.A. Kooij, Laura E. de Vries   +2 more
openaire   +5 more sources

Integrative proteomics and bioinformatic prediction enable a high-confidence apicoplast proteome in malaria parasites. [PDF]

PLoS Biology, 2018
Malaria parasites (Plasmodium spp.) and related apicomplexan pathogens contain a nonphotosynthetic plastid called the apicoplast. Derived from an unusual secondary eukaryote-eukaryote endosymbiosis, the apicoplast is a fascinating organelle whose ...
Michael J Boucher, Sreejoyee Ghosh, Lichao Zhang, Avantika Lal, Se Won Jang, An Ju, Shuying Zhang, Xinzi Wang, Stuart A Ralph, James Zou, Joshua E Elias, Ellen Yeh   +11 more
doaj   +3 more sources

Apicoplast-Localized Lysophosphatidic Acid Precursor Assembly Is Required for Bulk Phospholipid Synthesis in Toxoplasma gondii and Relies on an Algal/Plant-Like Glycerol 3-Phosphate Acyltransferase.

PLoS Pathogens, 2016
Most apicomplexan parasites possess a non-photosynthetic plastid (the apicoplast), which harbors enzymes for a number of metabolic pathways, including a prokaryotic type II fatty acid synthesis (FASII) pathway.
Souad Amiar, James I MacRae, Damien L Callahan, David Dubois, Giel G van Dooren, Melanie J Shears, Marie-France Cesbron-Delauw, Eric Maréchal, Malcolm J McConville, Geoffrey I McFadden, Yoshiki Yamaryo-Botté, Cyrille Y Botté   +11 more
doaj   +3 more sources

Characterization and annotation of Babesia orientalis apicoplast genome [PDF]

Parasites & Vectors, 2015
Background Babesia orientalis is an obligate intraerythrocytic protozoan parasite of the buffalo (Bubalus bubalis, Linnaeus, 1758) transmitted by the tick Rhipicephalus heamaphysaloides.
Yuan Huang, Lan He, Jinfang Hu, Pei He, Junwei He, Long Yu, Ngabu Malobi, Yanqin Zhou, Bang Shen, JunLong Zhao   +9 more
doaj   +2 more sources

Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparum. [PDF]

PLoS Biology, 2011
Plasmodium spp parasites harbor an unusual plastid organelle called the apicoplast. Due to its prokaryotic origin and essential function, the apicoplast is a key target for development of new anti-malarials. Over 500 proteins are predicted to localize to
Ellen Yeh, Joseph L DeRisi
doaj   +2 more sources

TgKDAC4: A Unique Deacetylase of Toxoplasma’s Apicoplast

Microorganisms, 2023
Toxoplasma gondii is an obligate intracellular parasite of the phylum Apicomplexa and causes toxoplasmosis infections, a disease that affects a quarter of the world’s population and has no effective cure.
Mariana Sayuri Ishikawa Fragoso, Caroline Moraes de Siqueira, Francisca Nathália Luna Vitorino, Alexandre Zanatta Vieira, Érica Santos Martins-Duarte, Helisson Faoro, Júlia Pinheiro Chagas da Cunha, Andréa Rodrigues Ávila, Sheila Cristina Nardelli   +8 more
doaj   +2 more sources

Two essential Thioredoxins mediate apicoplast biogenesis, protein import, and gene expression in Toxoplasma gondii. [PDF]

PLoS Pathogens, 2018
Apicomplexan parasites are global killers, being the causative agents of diseases like toxoplasmosis and malaria. These parasites are known to be hypersensitive to redox imbalance, yet little is understood about the cellular roles of their various redox ...
Marco Biddau, Anne Bouchut, Jack Major, Tracy Saveria, Julie Tottey, Ojore Oka, Marcel van-Lith, Katherine Elizabeth Jennings, Jana Ovciarikova, Amy DeRocher, Boris Striepen, Ross Frederick Waller, Marilyn Parsons, Lilach Sheiner   +13 more
doaj   +2 more sources

A pyruvate transporter in the apicoplast of apicomplexan parasites

Proceedings of the National Academy of Sciences
Pyruvate lies at a pivotal node of carbon metabolism in eukaryotes. It is involved in diverse metabolic pathways in multiple organelles, and its interorganelle shuttling is crucial for cell fitness. Many apicomplexan parasites harbor a unique organelle called the apicoplast that houses metabolic pathways like fatty acid and isoprenoid ...
Pu Chen, Yukun Chen, Ningbo Xia, Bolin Fan, Zhipeng Niu, Zhengming He, Xu Wang, Jing Yuan, Nishith Gupta, Bang Shen   +9 more
openaire   +3 more sources

Apicoplast-Resident Processes: Exploiting the Chink in the Armour of Plasmodium falciparum Parasites

Advances in Pharmacological and Pharmaceutical Sciences
The discovery of a relict plastid, also known as an apicoplast (apicomplexan plastid), that houses housekeeping processes and metabolic pathways critical to Plasmodium parasites’ survival has prompted increased research on identifying potent inhibitors ...
Collins Ojonugwa Mamudu, Mercy Eyitomi Tebamifor, Mary Ohunene Sule, Titilope Modupe Dokunmu, Olubanke Olujoke Ogunlana, Franklyn Nonso Iheagwam   +5 more
doaj   +2 more sources

Experimental Approaches for Examining Apicoplast Biology

, 2019
Genetic manipulation is a powerful tool to study gene function but identifying the direct and primary functional outcomes of any gene depletion is crucial for this strategy to be productive. This is a major challenge for the study of apicoplast biology, because, in the absence of an efficient isolation method, apicoplast functions must be assayed in ...
Marco, Biddau, Jana, Ovciarikova, Lilach, Sheiner   +2 more
openaire   +3 more sources