Results 1 to 10 of about 17,169 (224)

An essential adaptor for apicoplast fission and inheritance in malaria parasites [PDF]

Nature Communications
Blood-stage Plasmodium falciparum parasites rely on a non-photosynthetic plastid, the apicoplast, for survival, making it an attractive target for antimalarial intervention.
James A. Blauwkamp, Krithika Rajaram, Sophia R. Staggers, Oliver Harrigan, Emma H. Doud, Wei Xu, Hangjun Ke, Sean T. Prigge, Stella Y. Sun, Sabrina Absalon   +9 more
doaj   +6 more sources

F-actin and myosin F control apicoplast elongation dynamics which drive apicoplast-centrosome association in Toxoplasma gondii

MBio, 2023
Toxoplasma gondii contains an essential plastid organelle called the apicoplast that is necessary for fatty acid, isoprenoid, and heme synthesis. Perturbations affecting apicoplast function or inheritance lead to parasite death.
Aoife T Heaslip
exaly   +5 more sources

An apicoplast-localized GTPase is essential for Toxoplasma gondii survival [PDF]

mSphere
The apicoplast is an essential organelle found in Apicomplexa, a large phylum of intracellular eukaryotic pathogens. The apicoplast produces metabolites that are utilized for membrane biogenesis and energy production.
Michael B. Griffith, Morgan E. Wagner, Victoria L. Robinson, Aoife T. Heaslip   +3 more
doaj   +3 more sources

A novel YGGT family protein is localized in the apicoplast and is essential for the organelle inheritance [PDF]

Frontiers in Cellular and Infection Microbiology
Toxoplasma gondii is an obligate intracellular apicomplexan parasite. Most apicomplexan parasites contain an endosymbiont-derived organelle called the apicoplast. This organelle is critical for the survival of parasites because it plays a role in several
Wenqiang Su, Haorong Gu, Jun Zheng, Honglin Jia   +3 more
doaj   +3 more sources

Dissecting apicoplast functions through continuous cultivation of Toxoplasma gondii devoid of the organelle [PDF]

Nature Communications
The apicoplast, a relic plastid organelle derived from secondary endosymbiosis, is crucial for many medically relevant Apicomplexa. While it no longer performs photosynthesis, the organelle retains several essential metabolic pathways.
Min Chen, Szilamér Gyula Koszti, Alessandro Bonavoglia, Bohumil Maco, Olivier von Rohr, Hong-Juan Peng, Dominique Soldati-Favre, Joachim Kloehn   +7 more
doaj   +3 more sources

RAP proteins regulate apicoplast noncoding RNA processing in Plasmodium falciparum [PDF]

Cell Reports
Summary: The human malaria parasite, Plasmodium falciparum, contains a non-photosynthetic and essential plastid called the apicoplast. This organelle is of major interest for its unique biology and potential as an attractive drug target.
Thomas Hollin, Zeinab Chahine, Steven Abel, Charles Banks, Charisse Flerida A. Pasaje, Todd Lenz, Jacques Prudhomme, Caitlyn Marie Ybanez, Anahita S. Abbaszadeh, Jacquin C. Niles, Laurence Florens, Karine G. Le Roch   +11 more
doaj   +3 more sources

A P5-ATPase, TgFLP12, diverging from plant chloroplast lipid transporters mediates apicoplast fatty export in Toxoplasma [PDF]

Nature Communications
Toxoplasma gondii, an apicomplexan parasite and agent of the human disease toxoplasmosis, possesses a non-photosynthetic relic plastid, named the apicoplast.
Christophe-Sébastien Arnold, Anna-Maria Alazzi, Serena Shunmugam, Jan Janouškovec, Laurence Berry, Sarah Charital, Thierry Gautier, Samuel Duley, Delphine Jublot, Catherine Lemaire-Vieille, Marie-France Cesbron-Delauw, Pierre Cavailles, Jérôme Govin, Nicholas J. Katris, Yoshiki Yamaryo-Botté, Cyrille Y. Botté   +15 more
doaj   +3 more sources

Cellular Hallmarks From Volume Electron Microscopy Reveal Developmental Progression of Plasmodium Ookinetes. [PDF]

Adv Sci (Weinh)
This article presents a detailed ultrastructural cell atlas of Plasmodium ookinete development using advanced volume electron microscopy (v) techniques. It defines seven distinct developmental stages, revealing complex organelle interactions and offering new insights into parasite differentiation.
Darif N, Rheinnecker M, Hildenbrand K, Chookajorn T, Dorner LP, Hériché JK, Henriksson S, Funaya C, Hentzschel F, Sandblad L, Billker O, Schwab Y, Frischknecht F.   +12 more
europepmc   +2 more sources

A chaperonin complex regulates organelle proteostasis in malaria parasites. [PDF]

PLoS Pathogens
The apicoplast of Plasmodium parasites serves as a metabolic hub that synthesize essential biomolecules. Like other endosymbiotic organelles, 90% of the apicoplast proteome is encoded by the cell nucleus and transported to the organelle.
Amanda Tissawak, Yarden Rosin, Shirly Katz Galay, Alia Qasem, Michal Shahar, Nirit Trabelsi, Ora Furman-Schueler, Steven M Johnson, Anat Florentin   +8 more
doaj   +2 more sources

The Sea Cucumber-Infecting Parasite Apostichocystis gudetama gen. nov. sp. nov. Expands Marine-Host-Specific Clade of Apicomplexans. [PDF]

J Eukaryot Microbiol
ABSTRACT Unknown ellipsoid bodies, later classified as apicomplexan cysts, are prevalent in the ovaries of Japanese sea cucumbers (Apostichopus japonicus), where they can lead to lower fecundity in infected individuals and adverse effects on wild populations as well as aquaculture efforts for this endangered species.
Bonacolta AM, Krause-Massaguer J, Unuma T, Del Campo J.   +3 more
europepmc   +2 more sources