Results 1 to 10 of about 16,726 (193)

F-actin and myosin F control apicoplast elongation dynamics which drive apicoplast-centrosome association in Toxoplasma gondii

MBio, 2023
Toxoplasma gondii contains an essential plastid organelle called the apicoplast that is necessary for fatty acid, isoprenoid, and heme synthesis. Perturbations affecting apicoplast function or inheritance lead to parasite death.
Aoife Heaslip
exaly   +4 more sources

An essential adaptor for apicoplast fission and inheritance in malaria parasites [PDF]

Nature Communications
Blood-stage Plasmodium falciparum parasites rely on a non-photosynthetic plastid, the apicoplast, for survival, making it an attractive target for antimalarial intervention.
James A. Blauwkamp, Krithika Rajaram, Sophia R. Staggers, Oliver Harrigan, Emma H. Doud, Wei Xu, Hangjun Ke, Sean T. Prigge, Stella Y. Sun, Sabrina Absalon   +9 more
doaj   +3 more sources

Inheritance of four-membrane-bound structures in the “apicoplast-minus” Plasmodium falciparum [PDF]

mSphere
Most apicomplexan parasites contain a plastid-derived organelle called the apicoplast, which originated through secondary endosymbiosis. As a result of this evolutionary trajectory, the non-photosynthetic apicoplast is surrounded by four membranes and ...
Wei Xu, Ikechukwu Nwankwo, Sean T. Prigge, Hangjun Ke   +3 more
doaj   +2 more sources

An apicoplast-localized GTPase is essential for Toxoplasma gondii survival [PDF]

mSphere
The apicoplast is an essential organelle found in Apicomplexa, a large phylum of intracellular eukaryotic pathogens. The apicoplast produces metabolites that are utilized for membrane biogenesis and energy production.
Michael B. Griffith, Morgan E. Wagner, Victoria L. Robinson, Aoife T. Heaslip   +3 more
doaj   +2 more sources

Acyl carrier protein is essential for apicoplast biogenesis in malaria parasites independent of fatty acid synthesis [PDF]

eLife
Acyl carrier protein (ACP) and its 4-phosphopantetheine prosthetic group canonically function as the soluble scaffold for acyl chain assembly and elongation during type II fatty acid biosynthesis (FASII).
Sage WR Geher, Seyi Falekun, Jessica N Pita-Aquino, Russell P Swift, Megan Okada, Yasaman Jami-Alahmadi, James A Wohlschlegel, Sean T Prigge, Paul A Sigala   +8 more
doaj   +2 more sources

A novel YGGT family protein is localized in the apicoplast and is essential for the organelle inheritance [PDF]

Frontiers in Cellular and Infection Microbiology
Toxoplasma gondii is an obligate intracellular apicomplexan parasite. Most apicomplexan parasites contain an endosymbiont-derived organelle called the apicoplast. This organelle is critical for the survival of parasites because it plays a role in several
Wenqiang Su, Haorong Gu, Jun Zheng, Honglin Jia   +3 more
doaj   +2 more sources

ATG8 Is Essential Specifically for an Autophagy-Independent Function in Apicoplast Biogenesis in Blood-Stage Malaria Parasites

MBio, 2018
Plasmodium parasites and related pathogens contain an essential nonphotosynthetic plastid organelle, the apicoplast, derived from secondary endosymbiosis.
Jacquin Niles, Marta Walczak, Ellen Yeh   +2 more
exaly   +3 more sources

A P5-ATPase, TgFLP12, diverging from plant chloroplast lipid transporters mediates apicoplast fatty export in Toxoplasma [PDF]

Nature Communications
Toxoplasma gondii, an apicomplexan parasite and agent of the human disease toxoplasmosis, possesses a non-photosynthetic relic plastid, named the apicoplast.
Christophe-Sébastien Arnold, Anna-Maria Alazzi, Serena Shunmugam, Jan Janouškovec, Laurence Berry, Sarah Charital, Thierry Gautier, Samuel Duley, Delphine Jublot, Catherine Lemaire-Vieille, Marie-France Cesbron-Delauw, Pierre Cavailles, Jérôme Govin, Nicholas J. Katris, Yoshiki Yamaryo-Botté, Cyrille Y. Botté   +15 more
doaj   +2 more sources

RAP proteins regulate apicoplast noncoding RNA processing in Plasmodium falciparum [PDF]

Cell Reports
Summary: The human malaria parasite, Plasmodium falciparum, contains a non-photosynthetic and essential plastid called the apicoplast. This organelle is of major interest for its unique biology and potential as an attractive drug target.
Thomas Hollin, Zeinab Chahine, Steven Abel, Charles Banks, Charisse Flerida A. Pasaje, Todd Lenz, Jacques Prudhomme, Caitlyn Marie Ybanez, Anahita S. Abbaszadeh, Jacquin C. Niles, Laurence Florens, Karine G. Le Roch   +11 more
doaj   +2 more sources

A chaperonin complex regulates organelle proteostasis in malaria parasites. [PDF]

PLoS Pathogens
The apicoplast of Plasmodium parasites serves as a metabolic hub that synthesize essential biomolecules. Like other endosymbiotic organelles, 90% of the apicoplast proteome is encoded by the cell nucleus and transported to the organelle.
Amanda Tissawak, Yarden Rosin, Shirly Katz Galay, Alia Qasem, Michal Shahar, Nirit Trabelsi, Ora Furman-Schueler, Steven M Johnson, Anat Florentin   +8 more
doaj   +2 more sources