MBio, 2023 Toxoplasma gondii contains an essential plastid organelle called the apicoplast that is necessary for fatty acid, isoprenoid, and heme synthesis. Perturbations affecting apicoplast function or inheritance lead to parasite death.
Aoife Heaslip
exaly +3 more sources
An apicoplast-localized GTPase is essential for Toxoplasma gondii survival [PDF]
mSphereThe apicoplast is an essential organelle found in Apicomplexa, a large phylum of intracellular eukaryotic pathogens. The apicoplast produces metabolites that are utilized for membrane biogenesis and energy production.
Michael B. Griffith +3 more
doaj +2 more sources
An essential adaptor for apicoplast fission and inheritance in malaria parasites [PDF]
Nature CommunicationsBlood-stage Plasmodium falciparum parasites rely on a non-photosynthetic plastid, the apicoplast, for survival, making it an attractive target for antimalarial intervention.
James A. Blauwkamp +9 more
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A novel YGGT family protein is localized in the apicoplast and is essential for the organelle inheritance [PDF]
Frontiers in Cellular and Infection MicrobiologyToxoplasma gondii is an obligate intracellular apicomplexan parasite. Most apicomplexan parasites contain an endosymbiont-derived organelle called the apicoplast. This organelle is critical for the survival of parasites because it plays a role in several
Wenqiang Su +3 more
doaj +2 more sources
Veterinary ResearchToxoplasma gondii is among the most important parasites worldwide. The apicoplast is a unique organelle shared by all Apicomplexan protozoa.
Jie Xia +7 more
doaj +3 more sources
A P5-ATPase, TgFLP12, diverging from plant chloroplast lipid transporters mediates apicoplast fatty export in Toxoplasma [PDF]
Nature CommunicationsToxoplasma gondii, an apicomplexan parasite and agent of the human disease toxoplasmosis, possesses a non-photosynthetic relic plastid, named the apicoplast.
Christophe-Sébastien Arnold +15 more
doaj +2 more sources
RAP proteins regulate apicoplast noncoding RNA processing in Plasmodium falciparum [PDF]
Cell ReportsSummary: The human malaria parasite, Plasmodium falciparum, contains a non-photosynthetic and essential plastid called the apicoplast. This organelle is of major interest for its unique biology and potential as an attractive drug target.
Thomas Hollin +11 more
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Dissecting apicoplast functions through continuous cultivation of Toxoplasma gondii devoid of the organelle [PDF]
Nature CommunicationsThe apicoplast, a relic plastid organelle derived from secondary endosymbiosis, is crucial for many medically relevant Apicomplexa. While it no longer performs photosynthesis, the organelle retains several essential metabolic pathways.
Min Chen +7 more
doaj +2 more sources
A chaperonin complex regulates organelle proteostasis in malaria parasites. [PDF]
PLoS PathogensThe apicoplast of Plasmodium parasites serves as a metabolic hub that synthesize essential biomolecules. Like other endosymbiotic organelles, 90% of the apicoplast proteome is encoded by the cell nucleus and transported to the organelle.
Amanda Tissawak +8 more
doaj +2 more sources
Critical role for isoprenoids in apicoplast biogenesis by malaria parasites
eLife, 2022 Isopentenyl pyrophosphate (IPP) is an essential metabolic output of the apicoplast organelle in Plasmodium falciparum malaria parasites and is required for prenylation-dependent vesicular trafficking and other cellular processes.
Megan Okada +6 more
doaj +1 more source