Results 41 to 50 of about 16,726 (193)

GFP-targeting allows visualization of the apicoplast throughout the life cycle of live malaria parasites. [PDF]

, 2009
BACKGROUND INFORMATION The Plasmodium parasite, during its life cycle, undergoes three phases of asexual reproduction, these being repeated rounds of erythrocytic schizogony, sporogony within oocysts on the mosquito midgut wall and exo-erythrocytic ...
Zobiak, Bernd, Aepfelbacher, Martin, Stanway, Rebecca R, Witt, Tina, Heussler, Volker   +4 more
core   +1 more source

Chemical rescue of malaria parasites lacking an apicoplast defines organelle function in blood-stage Plasmodium falciparum.

PLoS Biology, 2011
Plasmodium spp parasites harbor an unusual plastid organelle called the apicoplast. Due to its prokaryotic origin and essential function, the apicoplast is a key target for development of new anti-malarials. Over 500 proteins are predicted to localize to
Ellen Yeh, Joseph L DeRisi
doaj   +1 more source

Integrative proteomics and bioinformatic prediction enable a high-confidence apicoplast proteome in malaria parasites.

PLoS Biology, 2018
Malaria parasites (Plasmodium spp.) and related apicomplexan pathogens contain a nonphotosynthetic plastid called the apicoplast. Derived from an unusual secondary eukaryote-eukaryote endosymbiosis, the apicoplast is a fascinating organelle whose ...
Michael J Boucher, Sreejoyee Ghosh, Lichao Zhang, Avantika Lal, Se Won Jang, An Ju, Shuying Zhang, Xinzi Wang, Stuart A Ralph, James Zou, Joshua E Elias, Ellen Yeh   +11 more
doaj   +1 more source

CaaX-Like Protease of Cyanobacterial Origin Is Required for Complex Plastid Biogenesis in Malaria Parasites

mBio, 2020
Plasmodium parasites and related apicomplexans contain an essential “complex plastid” organelle of secondary endosymbiotic origin, the apicoplast. Biogenesis of this complex plastid poses a unique challenge requiring evolution of new cellular machinery ...
Thomas R. Meister, Yong Tang, Michael J. Pulkoski-Gross, Ellen Yeh   +3 more
doaj   +1 more source

TgVPS15 regulates apicoplast biogenesis.

, 2022
A. IFA was performed on ΔKu80 or TgVPS15-iKD parasites treated with ATc for 1-5d to detect apicoplast using an antibody against Cpn60 and the pellicle was stained using anti-SAG1.
Rahul Singh Rawat (10204056), Pushkar Sharma (168246), Priyanka Bansal (8947484)   +2 more
core   +1 more source

A mevalonate bypass system facilitates elucidation of plastid biology in malaria parasites.

PLoS Pathogens, 2020
Malaria parasites rely on a plastid organelle for survival during the blood stages of infection. However, the entire organelle is dispensable as long as the isoprenoid precursor, isopentenyl pyrophosphate (IPP), is supplemented in the culture medium.
Russell P Swift, Krithika Rajaram, Hans B Liu, Amanda Dziedzic, Anne E Jedlicka, Aleah D Roberts, Krista A Matthews, Hugo Jhun, Namandje N Bumpus, Shivendra G Tewari, Anders Wallqvist, Sean T Prigge   +11 more
doaj   +1 more source

Theileria Apicoplast as a Target for Chemotherapy [PDF]

Antimicrobial Agents and Chemotherapy, 2009
ABSTRACT Theileria parasites cause severe bovine disease and death in a large part of the world. These apicomplexan parasites possess a relic plastid (apicoplast), whose metabolic pathways include several promising drug targets.
Regina, Lizundia, Dirk, Werling, Gordon, Langsley, Stuart A, Ralph   +3 more
openaire   +2 more sources

A Plastid Protein That Evolved from Ubiquitin and Is Required for Apicoplast Protein Import in Toxoplasma gondii

mBio, 2017
Apicomplexan parasites cause a variety of important infectious diseases, including malaria, toxoplasma encephalitis, and severe diarrhea due to Cryptosporidium.
Justin D. Fellows, Michael J. Cipriano, Swati Agrawal, Boris Striepen   +3 more
doaj   +1 more source

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Plasmodium falciparum Apicoplast Transit Peptides are Unstructured in vitro and During Apicoplast Import [PDF]

Traffic, 2011
Trafficking of soluble proteins to the apicoplast in Plasmodium falciparum is determined by an N‐terminal transit peptide (TP) which is necessary and sufficient for apicoplast import. Apicoplast precursor proteins are synthesized at the rough endoplasmic reticulum, but are then specifically sorted from other proteins in the secretory pathway.
John R, Gallagher, Krista A, Matthews, Sean T, Prigge   +2 more
openaire   +2 more sources