Results 41 to 50 of about 17,169 (224)

Apicoplast lipoic acid protein ligase B is not essential for Plasmodium falciparum [PDF]

, 2007
Lipoic acid (LA) is an essential cofactor of α-keto acid dehydrogenase complexes (KADHs) and the glycine cleavage system. In Plasmodium, LA is attached to the KADHs by organelle-specific lipoylation pathways.
Ryan Bissett, Carsten Wrenger, Gunther, M, Storm Janet, McMillan, Paul, Günther, S, Müller, S, Wallace, L., Muller, S., Patzewitz, Eva-Maria, Paul J McMillan, Lynsey Wallace, Wrenger, C., Günther, S., Bissett Ryan, Wrenger, Carsten, Smith, T.K., Muller, Sylke, McMillan Paul J, Bissett, Ryan, Guenther, Svenja, McMillan, Paul J., Smith, Terry, Sylke Müller, Patzewitz, E.-M., Terry K Smith, Storm, J., Günther Svenja, Storm, Janet, Svenja Günther, Patzewitz, EM, Wallace, Lynsey, Storm, J, McMillan, PJ, Patzewitz Eva-Maria, Mueller, Sylke, McMillan, P.J., Eva-Maria Patzewitz, Wallace Lynsey, Bissett, R, Wrenger, C, Janet Storm, Smith Terry K, Smith, TK, Wrenger Carsten, Smith, Terry K, Wallace, L, Bissett, R., Müller Sylke   +48 more
core   +1 more source

An apicoplast localized ubiquitylation system is required for the import of nuclear-encoded plastid proteins. [PDF]

PLoS Pathogens, 2013
Apicomplexan parasites are responsible for numerous important human diseases including toxoplasmosis, cryptosporidiosis, and most importantly malaria.
Swati Agrawal, Duk-Won D Chung, Nadia Ponts, Giel G van Dooren, Jacques Prudhomme, Carrie F Brooks, Elisadra M Rodrigues, John C Tan, Michael T Ferdig, Boris Striepen, Karine G Le Roch   +10 more
doaj   +1 more source

The Toxoplasma gondii Plastid replication and Repair Enzyme complex, PREX [PDF]

, 2009
A plastid-like organelle, the apicoplast, is essential to the majority of medically and veterinary important apicomplexan protozoa including Toxoplasma gondii and Plasmodium.
Chen, C-Y., Henriquez, F L, Roberts, C. W., Chen, C.Y., Barrett, M.P., Chen, C-Y, Barrett, M. P., Roberts, C W, Henriquez, F. L., Doerig, C., Roberts, C.W., Roberts, Craig, Mukhopadhyay, A, Chen, C.-Y., Mukhopadhyay, A., Henriquez, F.L., Barrett, M P, Doerig, C   +17 more
core   +1 more source

tRNA lysidinylation is essential for the minimal translation system in the Plasmodium falciparum apicoplast. [PDF]

EMBO Rep
For decades, researchers have sought to define minimal translation systems to uncover fundamental principles of life and advance biotechnology. tRNAs, essential components of this machinery, decode mRNA codons into amino acids.
Elahi R, Prigge ST.
europepmc   +2 more sources

PfClpC Is an Essential Clp Chaperone Required for Plastid Integrity and Clp Protease Stability in Plasmodium falciparum

Cell Reports, 2017
Summary: The deadly malaria parasite Plasmodium falciparum contains a nonphotosynthetic plastid, known as the apicoplast, that functions to produce essential metabolites, and drugs that target the apicoplast are clinically effective.
Anat Florentin, David W. Cobb, Jillian D. Fishburn, Michael J. Cipriano, Paul S. Kim, Manuel A. Fierro, Boris Striepen, Vasant Muralidharan   +7 more
doaj   +1 more source

Doxycycline has distinct apicoplast-specific mechanisms of antimalarial activity

eLife, 2020
Doxycycline (DOX) is a key antimalarial drug thought to kill Plasmodium parasites by blocking protein translation in the essential apicoplast organelle. Clinical use is primarily limited to prophylaxis due to delayed second-cycle parasite death at 1–3 µM
Megan Okada, Ping Guo, Shai-anne Nalder, Paul A Sigala   +3 more
doaj   +1 more source

Membrane and luminal proteins reach the apicoplast by different trafficking pathways in the malaria parasite Plasmodium falciparum [PDF]

PeerJ, 2017
The secretory pathway in Plasmodium falciparum has evolved to transport proteins to the host cell membrane and to an endosymbiotic organelle, the apicoplast. The latter can occur via the ER or the ER-Golgi route.
Rahul Chaudhari, Vishakha Dey, Aishwarya Narayan, Shobhona Sharma, Swati Patankar   +4 more
doaj   +2 more sources

TgVPS15 regulates apicoplast biogenesis.

, 2022
A. IFA was performed on ΔKu80 or TgVPS15-iKD parasites treated with ATc for 1-5d to detect apicoplast using an antibody against Cpn60 and the pellicle was stained using anti-SAG1.
Rahul Singh Rawat (10204056), Pushkar Sharma (168246), Priyanka Bansal (8947484)   +2 more
core   +1 more source

Experimental Genetics of Plasmodium berghei NFU in the Apicoplast Iron-Sulfur Cluster Biogenesis Pathway. [PDF]

PLoS ONE, 2013
Eukaryotic pathogens of the phylum Apicomplexa contain a non-photosynthetic plastid, termed apicoplast. Within this organelle distinct iron-sulfur [Fe-S] cluster proteins are likely central to biosynthesis pathways, including generation of isoprenoids ...
Joana M Haussig, Kai Matuschewski, Taco W A Kooij   +2 more
doaj   +1 more source

Disruption of Apicoplast Biogenesis by Chemical Stabilization of an Imported Protein Evades the Delayed-Death Phenotype in Malaria Parasites

mSphere, 2019
Malaria parasites (Plasmodium spp.) contain a nonphotosynthetic plastid organelle called the apicoplast, which houses essential metabolic pathways and is required throughout the parasite life cycle.
Michael J. Boucher, Ellen Yeh
doaj   +1 more source