Results 41 to 50 of about 14,891 (174)

Inheritance of four-membrane-bound structures in the “apicoplast-minus” Plasmodium falciparum

mSphere
Most apicomplexan parasites contain a plastid-derived organelle called the apicoplast, which originated through secondary endosymbiosis. As a result of this evolutionary trajectory, the non-photosynthetic apicoplast is surrounded by four membranes and ...
Wei Xu, Ikechukwu Nwankwo, Sean T. Prigge, Hangjun Ke   +3 more
doaj   +1 more source

Division and Adaptation to Host Environment of Apicomplexan Parasites Depend on Apicoplast Lipid Metabolic Plasticity and Host Organelle Remodeling

Cell Reports, 2020
Summary: Apicomplexan parasites are unicellular eukaryotic pathogens that must obtain and combine lipids from both host cell scavenging and de novo synthesis to maintain parasite propagation and survival within their human host.
Souad Amiar, Nicholas J. Katris, Laurence Berry, Sheena Dass, Samuel Duley, Christophe-Sebastien Arnold, Melanie J. Shears, Camille Brunet, Bastien Touquet, Geoffrey I. McFadden, Yoshiki Yamaryo-Botté, Cyrille Y. Botté   +11 more
doaj   +1 more source

Phytochemical Diversity, Nutritional Values, and Biological Properties of Halopithys incurva (Hudson) Batters, 1902

Food Science &Nutrition, Volume 14, Issue 4, April 2026.
Halopithys incurva is a red macroalga distributed across the Mediterranean Sea and North‐East Atlantic, with occasional reports from the Indian Ocean. It exhibits a rich chemical diversity, including isoflavones, bromophenols, MAAs, pigments, phycobiliproteins, primary metabolites, and neuroactive compounds.
Youssra Aalilou, Abdelhakim Bouyahya, Kaoutar Benrahou, Mustapha Hassoun, Hanaa Moussa, Issam Ameziane El Hassani, Waleed Al Abdulmonem, Learn‐Han Lee, Gokhan Zengin, My El Abbes Faouzi   +9 more
wiley   +1 more source

Sequence and annotation of the apicoplast genome of the human pathogen Babesia microti. [PDF]

PLoS ONE, 2014
The apicomplexan intraerythrocytic parasite Babesia microti is an emerging human pathogen and the primary cause of human babesiosis, a malaria-like illness endemic in the United States.
Aprajita Garg, Anna Stein, William Zhao, Ankit Dwivedi, Roger Frutos, Emmanuel Cornillot, Choukri Ben Mamoun   +6 more
doaj   +1 more source

Characterization of the apicoplast-localized enzyme TgUroD in Toxoplasma gondii reveals a key role of the apicoplast in heme biosynthesis [PDF]

Journal of Biological Chemistry, 2020
Apicomplexan parasites such as Toxoplasma gondii possess an unusual heme biosynthesis pathway whose enzymes localize to the mitochondrion, cytosol, or apicoplast, a nonphotosynthetic plastid present in most apicomplexans. To characterize the involvement of the apicoplast in the T.
Edwin T. Tjhin, Jenni A. Hayward, Geoffrey I. McFadden, Giel G. van Dooren   +3 more
openaire   +3 more sources

Evolutionary divergence and functional insights into the heteromeric cis‐prenyltransferase of Paramecium tetraurelia

The FEBS Journal, Volume 293, Issue 6, Page 1681-1707, March 2026.
Heteromeric cis‐prenyltransferases (CPT) are indispensable for dolichol synthesis and protein N‐glycosylation in most eukaryotes. The catalytic subunits are strongly conserved throughout evolution, in contrast to the evolutionarily variable accessory subunits. The POC1 protein from Paramecium tetraurelia is the smallest identified CPT‐accessory subunit
Agnieszka Onysk, Kamil Steczkiewicz, Mariusz Radkiewicz, Paweł Link‐Lenczowski, Przemysław Surowiecki, Karolina Sztompka, Kariona A. Grabińska, Jacek K. Nowak, Liliana Surmacz   +8 more
wiley   +1 more source

Two essential Thioredoxins mediate apicoplast biogenesis, protein import, and gene expression in Toxoplasma gondii.

PLoS Pathogens, 2018
Apicomplexan parasites are global killers, being the causative agents of diseases like toxoplasmosis and malaria. These parasites are known to be hypersensitive to redox imbalance, yet little is understood about the cellular roles of their various redox ...
Marco Biddau, Anne Bouchut, Jack Major, Tracy Saveria, Julie Tottey, Ojore Oka, Marcel van-Lith, Katherine Elizabeth Jennings, Jana Ovciarikova, Amy DeRocher, Boris Striepen, Ross Frederick Waller, Marilyn Parsons, Lilach Sheiner   +13 more
doaj   +1 more source

Plasmodium falciparum Apicoplast Transit Peptides are Unstructured in vitro and During Apicoplast Import [PDF]

Traffic, 2011
Trafficking of soluble proteins to the apicoplast in Plasmodium falciparum is determined by an N‐terminal transit peptide (TP) which is necessary and sufficient for apicoplast import. Apicoplast precursor proteins are synthesized at the rough endoplasmic reticulum, but are then specifically sorted from other proteins in the secretory pathway.
John R, Gallagher, Krista A, Matthews, Sean T, Prigge   +2 more
openaire   +2 more sources

Functional Interaction Between Toc75 POTRA1 Domain and Tic22‐III in the Intermembrane Space During Chloroplast Protein Import

Plant Direct, Volume 10, Issue 2, February 2026.
ABSTRACT Chaperones are essential for facilitating the import of nuclear‐encoded precursor proteins into chloroplasts. In the intermembrane space (IMS) of the chloroplasts, this process is mediated by the transport‐associated domains (POTRA) of the translocon at the outer envelope membrane (Toc75) and translocon at the inner envelope membrane (Tic22 ...
Rajneesh Singhal, Danny J. Schnell
wiley   +1 more source

Imaging malaria parasites across scales and time

Journal of Microscopy, Volume 301, Issue 2, Page 122-150, February 2026.
Abstract The idea that disease is caused at the cellular level is so fundamental to us that we might forget the critical role microscopy played in generating and developing this insight. Visually identifying diseased or infected cells lays the foundation for any effort to curb human pathology.
Julien Guizetti
wiley   +1 more source