Results 71 to 80 of about 17,169 (224)

Functional Interaction Between Toc75 POTRA1 Domain and Tic22‐III in the Intermembrane Space During Chloroplast Protein Import

Plant Direct, Volume 10, Issue 2, February 2026.
ABSTRACT Chaperones are essential for facilitating the import of nuclear‐encoded precursor proteins into chloroplasts. In the intermembrane space (IMS) of the chloroplasts, this process is mediated by the transport‐associated domains (POTRA) of the translocon at the outer envelope membrane (Toc75) and translocon at the inner envelope membrane (Tic22 ...
Rajneesh Singhal, Danny J. Schnell
wiley   +1 more source

Ycf93 (Orf105), a small apicoplast-encoded membrane protein in the relict plastid of the malaria parasite Plasmodium falciparum that is conserved in Apicomplexa.

PLoS ONE, 2014
Malaria parasites retain a relict plastid (apicoplast) from a photosynthetic ancestor shared with dinoflagellate algae. The apicoplast is a useful drug target; blocking housekeeping pathways such as genome replication and translation in the organelle ...
Christopher D Goodman, Geoffrey I McFadden   +1 more
doaj   +1 more source

Roles of Ferredoxin-Dependent Proteins in the Apicoplast of Plasmodium falciparum Parasites

mBio, 2022
Ferredoxin (Fd) and ferredoxin-NADP+ reductase (FNR) form a redox system that is hypothesized to play a central role in the maintenance and function of the apicoplast organelle of malaria parasites.
Russell P. Swift, Krithika Rajaram, Rubayet Elahi, Hans B. Liu, Sean T. Prigge   +4 more
doaj   +1 more source

Imaging malaria parasites across scales and time

Journal of Microscopy, Volume 301, Issue 2, Page 122-150, February 2026.
Abstract The idea that disease is caused at the cellular level is so fundamental to us that we might forget the critical role microscopy played in generating and developing this insight. Visually identifying diseased or infected cells lays the foundation for any effort to curb human pathology.
Julien Guizetti
wiley   +1 more source

Plasmodium falciparum Apicoplast Transit Peptides are Unstructured in vitro and During Apicoplast Import [PDF]

Traffic, 2011
Trafficking of soluble proteins to the apicoplast in Plasmodium falciparum is determined by an N‐terminal transit peptide (TP) which is necessary and sufficient for apicoplast import. Apicoplast precursor proteins are synthesized at the rough endoplasmic reticulum, but are then specifically sorted from other proteins in the secretory pathway.
John R, Gallagher, Krista A, Matthews, Sean T, Prigge   +2 more
openaire   +2 more sources

Optimisation of freeze substitution protocols for the examination of malaria parasite structure by volumetric electron microscopy

Journal of Microscopy, Volume 301, Issue 2, Page 168-186, February 2026.
Abstract Malaria is one of the deadliest infectious diseases in the world, annually responsible for over 400,000 deaths. It is caused by parasites of the genus Plasmodium, which undergo remarkable structural changes during their development within different cells across various hosts.
Rachel Rachid, Camila Wendt, Wanderley de Souza, Kildare Miranda   +3 more
wiley   +1 more source

Deciphering apicoplast targeting signals – feature extraction from nuclear-encoded precursors of Plasmodium falciparum apicoplast proteins

, 2001
The malaria causing protozoan Plasmodium falciparum contains a vestigal, non-photosynthetic plastid, the apicoplast. Numerous proteins encoded by nuclear genes are targeted to the apicoplast courtesy of N-terminal extensions.
Jochen Zuegge, Geoffrey I McFadden, Stuart Ralph (7117511), Michael Schmuker (4736406), Stuart Ralph, Michael Schmuker, Gisbert Schneider, Gisbert Schneider (17096), Jochen Zuegge (16193990), Geoffrey I McFadden (9540920)   +9 more
core   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, Volume 600, Issue 2, Page 251-266, January 2026.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Distribution of the expected apicoplast targets according to their predicted metabolic function in the apicoplast.

, 2013
Distribution of the expected apicoplast targets according to their predicted metabolic function in the apicoplast.
Lourival Almeida Silva (394482), Nadlla Alves Bispo (394481), Pedro Cravo (192117), Richard Culleton (115275)   +3 more
core   +1 more source

Antimalarial activity of Mangifera indica aqueous extract in Plasmodium berghei’s apicoplast

Tropical Journal of Pharmaceutical Research, 2023
Purpose: To investigate the in vivo antiplasmodial effect of Mangifera indica aqueous extract in Plasmodium berghei-infected mice, and to characterize  its phytochemical constituents and their mechanism of action.
E. Asanga, H. Okoroiwu, U. Edet, Dennis Amaechi, Promise E Nelson, M. Uchenwa, O. Eseyin, Goodnews Samuel, Lordswill A. Ettah, Osuake A. Obongha   +9 more
semanticscholar   +1 more source