Results 71 to 80 of about 16,726 (193)
Integrative Zoology, Volume 21, Issue 1, Page 137-150, January 2026.This study identifies Polychromophilus sp. in blood‐feeding flies (Basilia speiseri and Basilia lindolphoi) from Myotis nigricans bats in Brazil, marking the first molecular detection of the parasite in an insect vector in this country. Two haplotypes were identified, both within the Polychromophilus murinus group.
Bruno S. Mathias +7 more
wiley +1 more source
, 2013 Distribution of the expected apicoplast targets according to their predicted metabolic function in the apicoplast.
Lourival Almeida Silva (394482) +3 more
core +1 more source
Gene Expression, Docking and Machine Learning in Malaria Drug Discovery: A Systematic Review
Biochemistry Research International, Volume 2026, Issue 1, 2026.Background Malaria remains a significant and worldwide health threat with increasing resistance to current treatments, stimulating the demand for innovative approaches in pursuing drug discovery. This systematic review integrates the progress made from 2014 through 2024 regarding molecular methods like gene expression profiling, molecular docking and ...
Reuben Samson Dangana +5 more
wiley +1 more source
A systematic screen to discover and analyze apicoplast proteins identifies a conserved and essential protein import factor. [PDF]
PLoS Pathogens, 2011 Parasites of the phylum Apicomplexa cause diseases that impact global health and economy. These unicellular eukaryotes possess a relict plastid, the apicoplast, which is an essential organelle and a validated drug target.
Lilach Sheiner +7 more
doaj +1 more source
Antimalarial Potential of Synthetic Geraniol and Nerol Analogs
Journal of Chemistry, Volume 2026, Issue 1, 2026.Drug resistance is a major threat to malaria control; therefore, new drugs are required to combat this parasitosis. To accelerate drug development, the exploration of natural compounds or the repositioning of drugs already employed for other diseases is of particular interest.
Maurício Mazzine Filho +15 more
wiley +1 more source
, 2001 The malaria causing protozoan Plasmodium falciparum contains a vestigal, non-photosynthetic plastid, the apicoplast. Numerous proteins encoded by nuclear genes are targeted to the apicoplast courtesy of N-terminal extensions.
Jochen Zuegge +9 more
core +1 more source
Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.The emergence of infectious diseases associated with land‐use changes is well‐documented. However, the presence and dynamics of zoonotic pathogens in small mammals within European forests, whether from rural development or urban greening, remain underexplored.
Marie Bouilloud +15 more
wiley +1 more source
Colocalization of Atg8 and the apicoplast.
, 2014 The indicated stages of P. falciparum D10 parasites expressing the apicoplast marker ACP-GFP were evaluated for colocalization of PfAtg8 with the apicoplast as described in Materials and Methods section.
Atul (113444) +3 more
core +1 more source
A mutagenesis screen for essential plastid biogenesis genes in human malaria parasites.
PLoS Biology, 2019 Endosymbiosis has driven major molecular and cellular innovations. Plasmodium spp. parasites that cause malaria contain an essential, non-photosynthetic plastid-the apicoplast-which originated from a secondary (eukaryote-eukaryote) endosymbiosis.
Yong Tang +7 more
doaj +1 more source
A Novel Antimalarial Agent that Inhibits Protein Synthesis in Plasmodium falciparum
Angewandte Chemie International Edition, Volume 64, Issue 49, December 1, 2025.Compound 31 represents a promising avenue for the development as an antimalarial agent with a potent activity profile (PfNF54 IC50 ± s.d. = 3.9 ± 0.4 nM). It has a novel mode of action by binding to cytosolic ribosomal subunits, thereby inhibiting protein synthesis in the parasite.
Patricia Bravo +16 more
wiley +1 more source