Results 71 to 80 of about 14,891 (174)
Inheritance of the genome-less apicoplast in the “apicoplast-minus” Plasmodium falciparum
Abstract Most apicomplexan parasites contain a plastid-derived organelle called the apicoplast, which originated through secondary endosymbiosis. As a result of this evolutionary trajectory, the non-photosynthetic apicoplast is surrounded by four membranes and contains many bacterial-like, druggable targets.
Xu, Wei +3 more
openaire +2 more sources
Hybrid Molecules as Efficient Drugs against Multidrug‐Resistant Malaria Parasites
ChemMedChem, Volume 20, Issue 11, June 2, 2025.Among hybrid molecules currently developed as antimalarial drug candidates, emoquine‐1 exhibits high activity against all the multidrug‐resistant Plasmodium strains tested up to now, including artemisinin‐resistant quiescent parasites, critical parameters for promising antimalarial drugs. It is also curative in mouse malaria.
Anne Robert +6 more
wiley +1 more source
PLoS ONE, 2018 The life cycle of Plasmodium falciparum, the agent responsible for malaria, depends on both cytosolic and apicoplast translation fidelity. Apicoplast aminoacyl-tRNA synthetases (aaRS) are bacterial-like enzymes devoted to organellar tRNA aminoacylation ...
Marta Cela +5 more
doaj +1 more source
Biomolecules, 2019 The phylum Apicomplexa (Alveolates) comprises a group of host-associated protists, predominately intracellular parasites, including devastating parasites like Plasmodium falciparum, the causative agent of malaria.
Eric D. Salomaki, Martin Kolisko
doaj +1 more source
PLoS Pathogens, 2016 Most apicomplexan parasites possess a non-photosynthetic plastid (the apicoplast), which harbors enzymes for a number of metabolic pathways, including a prokaryotic type II fatty acid synthesis (FASII) pathway.
Souad Amiar +11 more
doaj +1 more source
The apicoplast: a red alga in human parasites [PDF]
Essays in Biochemistry, 2011 Surprisingly, some of the world's most dangerous parasites appear to have had a benign photosynthetic past in the ocean. The phylum Apicomplexa includes the causative agents of malaria and a number of additional human and animal diseases. These diseases threaten the life and health of hundreds of millions each year and pose a tremendous challenge to ...
openaire +2 more sources
Small molecule inhibition of apicomplexan FtsH1 disrupts plastid biogenesis in human pathogens
eLife, 2017 The malaria parasite Plasmodium falciparum and related apicomplexan pathogens contain an essential plastid organelle, the apicoplast, which is a key anti-parasitic target. Derived from secondary endosymbiosis, the apicoplast depends on novel, but largely
Katherine Amberg-Johnson +6 more
doaj +1 more source
Autophagy-Related Protein ATG18 Regulates Apicoplast Biogenesis in Apicomplexan Parasites
mBio, 2017 Mechanisms by which 3′-phosphorylated phosphoinositides (3′-PIPs) regulate the development of apicomplexan parasites Plasmodium falciparum and Toxoplasma gondii are poorly understood.
Priyanka Bansal +4 more
doaj +1 more source
Apicoplast-Resident Processes: Exploiting the Chink in the Armour of Plasmodium falciparum Parasites
Advances in Pharmacological and Pharmaceutical SciencesThe discovery of a relict plastid, also known as an apicoplast (apicomplexan plastid), that houses housekeeping processes and metabolic pathways critical to Plasmodium parasites’ survival has prompted increased research on identifying potent inhibitors ...
Collins Ojonugwa Mamudu +5 more
doaj +1 more source