Results 181 to 190 of about 17,169 (224)

The apicoplast biogenesis and metabolism: current progress and questions.

Trends in Parasitology
Many apicomplexan parasites have a chloroplast-derived apicoplast containing several metabolic pathways. Recent studies have greatly expanded our understanding of apicoplast biogenesis and metabolism while also raising new questions.
Xiaowei Chen, Xun Suo, Guan Zhu, Bang Shen   +3 more
semanticscholar   +1 more source

Plasmodium falciparum ZIP1 Is a Zinc-Selective Transporter with Stage-Dependent Targeting to the Apicoplast and Plasma Membrane in Erythrocytic Parasites.

ACS Infectious Diseases
Replication of the malarial parasite in human erythrocytes requires massive zinc fluxes, necessitating the action of zinc transporters across the parasite plasma and organellar membranes.
D. Shrivastava, Akanksha Jha, Rajlakshmi Kabrambam, Jyoti Vishwakarma, Kalyan Mitra, Ravishankar Ramachandran, Saman Habib   +6 more
semanticscholar   +1 more source

Comment on "A Green Algal Apicoplast Ancestor"

Science, 2003
Discovery of a plastid in apicomplexan parasites such as Toxoplasma and Plasmodium ( [1][1], [2][2] ) has prompted intense debate over whether the plastid originates from a red algal or a green algal ancestor ( [3][3]–[5][4] ). Funes et al.
Ross F, Waller, Patrick J, Keeling, Giel G, van Dooren, Geoffrey I, McFadden   +3 more
openaire   +2 more sources

Cryo-EM Structures of the Plasmodium falciparum Apicoplast DNA Polymerase

Journal of Molecular Biology
The apicoplast DNA polymerase (apPol) from Plasmodium falciparum is essential for the parasite’s survival, making it a prime target for antimalarial therapies.
Chen-Yu Lo, Adron R. Ung, Tirthankar Koley, Scott W. Nelson, Yang Gao   +4 more
semanticscholar   +1 more source

The Apicoplast: A Parasite’s Symbiont

2014
The endosymbiotic capture of a red alga brought photosynthesis to a previously heterotrophic protist, and marked the birth of a now very diverse new branch of the eukaryotic tree of life. Among the many plastid-bearing descendants of this event are the Apicomplexa, a phylum of obligate animal parasites.
Lilach Sheiner, Boris Striepen
openaire   +1 more source

Phylogeny and evolution of apicoplasts and apicomplexan parasites

Parasitology International, 2015
The phylum Apicomplexa includes many parasitic genera of medical and veterinary importance including Plasmodium (causative agent of malaria), Toxoplasma (toxoplasmosis), and Babesia (babesiosis). Most of the apicomplexan parasites possess a unique, essential organelle, the apicoplast, which is a plastid without photosynthetic ability.
Nobuko Arisue, Tetsuo Hashimoto
openaire   +2 more sources

Apicoplast Metabolism: Parasite’s Achilles’ Heel

Current Topics in Medicinal Chemistry, 2019
Malaria continues to impinge heavily on mankind, with five continents still under its clasp. Widespread and rapid emergence of drug resistance in the Plasmodium parasite to current therapies accentuate the quest for novel drug targets and antimalarial compounds. Plasmodium parasites, maintain a non-photosynthetic relict organelle known as Apicoplast.
Kavita, Kadian, Yash, Gupta, Harsh Vardhan, Singh, Prakasha, Kempaiah, Manmeet, Rawat   +4 more
openaire   +2 more sources

In artemisinin-resistant falciparum malaria parasites, mitochondrial metabolic pathways are essential for survival but not those of apicoplast

International Journal for Parasitology: Drugs and Drug Resistance
Emergence and spread of parasite resistance to artemisinins, the first-line antimalarial therapy, threaten the malaria eradication policy. To identify therapeutic targets to eliminate artemisinin-resistant parasites, the functioning of the apicoplast and
M. Ouji, Thibaud Reyser, Yoshiki Yamaryo-Botté, Michel Nguyen, D. Rengel, Axelle Dutreuil, M. Marcellin, O. Burlet-Schiltz, J. Augereau, M. Riscoe, L. Paloque, Cyrille Y. Botté, F. Benoit‐Vical   +12 more
semanticscholar   +1 more source

3-Benzylmenadiones and their Heteroaromatic Analogues Target the Apicoplast of Apicomplexa Parasites: Synthesis and Bioimaging Studies.

ACS Infectious Diseases
The apicoplast is an essential organelle for the viability of apicomplexan parasites Plasmodium falciparum or Toxoplasma gondii, which has been proposed as a suitable drug target for the development of new antiplasmodial drug-candidates.
Baptiste Dupouy, M. Donzel, Matthieu Roignant, Sarah Charital, Rodrigue Keumoe, Yoshiki Yamaryo-Botté, A. Feckler, M. Bundschuh, Yann Bordat, Matthias Rottmann, Pascal Mäser, Cyrille Y. Botté, Stéphanie A Blandin, Sébastien Besteiro, E. Davioud‐Charvet   +14 more
semanticscholar   +1 more source

N-terminal targeting sequences and coding sequences act in concert to determine the localization and trafficking pathway of apicoplast proteins in Toxoplasma gondii

bioRxiv
Toxoplasma gondii has a relict plastid, the apicoplast, to which proteins are targeted after synthesis in the cytosol. Proteins exclusively found in the apicoplast use a Golgi-independent route for trafficking, while dually targeted proteins found in ...
Sofia Anjum, Aparna Prasad, Pragati Mastud, S. Patankar   +3 more
semanticscholar   +1 more source