Results 111 to 120 of about 111,354 (312)
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
JISC Good APIs Management Report
, 2009 The JISC funds research and innovation programmes in the use of ICT in teaching, learning and in the building of knowledge and service development.
Guy, Marieke
core
Nosema apis in drone honeybees
, 1972 SummaryDrone honeybees were found to be at least as susceptible as workers to infection by Nosema apis, and the median infective dose was fewer than 100 spores.
Bailey, L.
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Semantic APIs: scaling up towards the Semantic Web
, 2010 Web information retrieval and knowledge discovery are undergoing changes. The size of the Web and the heterogeneity of web pages generate new challenges in meeting user needs.
Dotsika, F.
core +1 more source
Prioritisation of data-poor pharmaceuticals for empirical testing and environmental risk assessment
Environment InternationalThere are more than 3,500 active pharmaceutical ingredients (APIs) on the global market for human and veterinary use. Residues of these APIs eventually reach the aquatic environment.
Cristiana Cannata +7 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Nosema apis and dysentery of the Honeybee
, 1967 SUMMARYSevere winter losses of honeybee colonies and poor growth or dwindling in spring were associated with dysentery. They were not caused simply by an enzootic infection with Nosema apis.
Bailey, L.
core +1 more source
Evolutionary trends in Bombella apis CRISPR-Cas systems
mSystemsBacteria and archaea employ a rudimentary immune system, CRISPR-Cas, to protect against foreign genetic elements such as bacteriophage. CRISPR-Cas systems are found in Bombella apis. B.
Carrie L. Ganote +4 more
doaj +1 more source