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Aplastic anemia [PDF]

Current Opinion in Internal Medicine, 2008
Most acquired aplastic anemia is the result of immune-mediated destruction of hematopoietic stem cells causing pancytopenia and an empty bone marrow, which can be successfully treated with either immunosuppressive therapy or hematopoietic stem-cell transplantation.In aplastic anemia, oligoclonally expanded cytotoxic T cells induce apoptosis of ...
Neal S, Young, Phillip, Scheinberg, Rodrigo T, Calado   +2 more
openaire   +2 more sources

Experiences and Support Needs of Caregivers of Patients with Higher-Risk Myelodysplastic Syndrome via Online Bulletin Board in the USA, Canada and UK

Oncology and Therapy, 2023
Introduction Patients with higher-risk myelodysplastic syndromes (MDS) face considerable challenges in disease management and often require caregiver support.
Pauline Frank, Anne Olshan, Tracey Iraca, Cindy Anthony, Sophie Wintrich, Emma Sasse   +5 more
doaj   +1 more source

Predicting response of severe aplastic anemia to immunosuppression combined with eltrombopag

Haematologica, 2021
Pretreatment blood counts, particularly an absolute reticulocyte count ≥25×109/L, correlate with response to immunosuppressive therapy in severe aplastic anemia.
Yoshitaka Zaimoku, B. Patel, R. Shalhoub, E. Groarke, Xingmin Feng, Colin O. Wu, N. Young   +6 more
semanticscholar   +1 more source

Diagnostic work‐up for severe aplastic anemia in children: Consensus of the North American Pediatric Aplastic Anemia Consortium

American journal of hematology/oncology, 2021
The North American Pediatric Aplastic Anemia Consortium (NAPAAC) is a group of pediatric hematologist‐oncologists, hematopathologists, and bone marrow transplant physicians from 46 institutions in North America with interest and expertise in aplastic ...
K. Shimano, A. Narla, M. Rose, N. Gloude, S. Allen, Katie Bergstrom, Larisa Broglie, Beth A. Carella, Paul Castillo, Jill L. O. de Jong, Y. Dror, A. Geddis, James N. Huang, B. Lau, C. McGuinn, Taizo A Nakano, K. Overholt, J. Rothman, A. Sharathkumar, E. Shereck, A. Vlachos, T. Olson, A. Bertuch, M. Wlodarski, A. Shimamura, Jessica Boklan   +25 more
semanticscholar   +1 more source

Telomere length of various blood and bone marrow cells in patients with aplastic anemia

Онкогематология, 2023
Background. Aplastic anemia proceeds with bone marrow failure and is associated with immunological suppression of normal blood stem cells’ proliferation, which lead to bone marrow aplasia.
A. V. Luchkin, E. A. Mikhailova, I. V. Galtseva, Z. T. Fidarova, A. V. Abramova, Yu. O. Davydova, N. M. Kapranov, K. A. Nikiforova, S. M. Kulikov, E. N. Parovichnikova   +9 more
doaj   +1 more source

COVID-19-related acute necrotizing encephalopathy with brain stem involvement in a patient with aplastic anemia

Neurology: Neuroimmunology & Neuroinflammation, 2020
Objective To describe a novel case of coronavirus disease 2019 (COVID-19)-associated acute necrotizing encephalopathy (ANE) in a patient with aplastic anemia where there was early brain stem-predominant involvement.
Luke Dixon, J. Varley, A. Gontsarova, D. Mallon, F. Tona, D. Muir, A. Luqmani, I. H. Jenkins, R. Nicholas, B. Jones, A. Everitt   +10 more
semanticscholar   +1 more source

Aplastic Anemia Treated with Eltrombopag during Pregnancy

Case Reports in Obstetrics and Gynecology, 2022
Aplastic anemia is a rare blood disorder characterized by pancytopenia and hypocellular bone marrow. In patients with aplastic anemia, pancytopenia sometimes worsens during pregnancy, and relapse of aplastic anemia in pregnancy is common.
Yuri Suminaga, Yoshitsugu Chigusa, Tadakazu Kondo, Haruko Okamoto, Yosuke Kawamura, Mana Taki, Masaki Mandai, Haruta Mogami   +7 more
doaj   +1 more source

Aplastic anemia in China [PDF]

Journal of Translational Internal Medicine, 2018
Abstract Aplastic anemia (AA) is a hematologic disease characterized by pancytopenia. Up to now, severe aplastic anemia (SAA) has been recognized by international and domestic scholars as an autoimmune disease with bone marrow (BM) failure mediated by the hyperfunctional T lymphocytes.
Chunyan Liu, Zonghong Shao
openaire   +3 more sources

Secondary myelodysplastic syndrome and leukemia in acquired aplastic anemia and paroxysmal nocturnal hemoglobinuria.

Blood, 2020
Acquired aplastic anemia (AA) and paroxysmal nocturnal hemoglobinuria (PNH) are pathogenically related non-malignant bone marrow failure disorders linked to T-cell mediated autoimmunity and associated with an increased risk of secondary myelodysplastic ...
Lova Sun, D. Babushok
semanticscholar   +1 more source

Thrombopoietin Promotes Cell Proliferation and Attenuates Apoptosis of Aplastic Anemia Serum-Treated 32D Cells via Activating STAT3/STAT5 Signaling Pathway and Modulating Apoptosis-Related Mediators

Cell Transplantation, 2021
The present study aimed to investigate the effect and possible mechanism of recombinant human thrombopoietin (rhTPO) on mouse 32D cells (a mouse myeloid progenitor cell line) treated with serum from patients with aplastic anemia and to elucidate the ...
Juan Qian, Xin Cao, Qian Shen, Yi-feng Cai, Wei Lu, Hong Yin, Xue-fen You, Hong Liu   +7 more
doaj   +1 more source