Results 71 to 80 of about 345,333 (344)

Aplastic anemia: Etiology, molecular pathogenesis, and emerging concepts

European Journal of Haematology, 2018
Aplastic anemia (AA) is rare disorder of bone marrow failure which if severe and not appropriately treated is highly fatal. AA is characterized by morphologic marrow features, namely hypocellularity, and resultant peripheral cytopenias.
R. Shallis, R. Ahmad, A. Zeidan
semanticscholar   +1 more source

Scurvy: A treatable forgotten fatal differential diagnosis and potential etiology of leukemia and aplastic anemia in pediatric population

Health Science Reports, 2023
Scurvy is a rare nutritional deficiency disease which is less likely to be suspected and it mostly lead to delayed diagnosis. It can present with features which can mislead clinicians to misdiagnose the condition as leukemia or aplastic anemia.
Harold L. Mashauri
doaj   +1 more source

Показатели обмена глюкозы в эритроцитах при отдельных гематологических заболеваниях [PDF]

, 2013
Установлено, що за еритремії, апластичній анемії та залізодефіцитній анемії в еритроцитах відбувається інтенсифікація гліколітичних реакцій, про що свідчить підвищення активності гексокінази і вмісту метаболіту гліколізу – фосфоенолпірувату, а також ...
Казакова, В.В., Коношенко, С.В., Ёлкина, Н.М.   +2 more
core  

Dysfunctional telomeres in primary cells from Fanconi anemia FANCD2 patients [PDF]

, 2012
© 2012 Joksic et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium ...
Guc-Scekic, M, Joksic, G, Joksic, I, Leskovac, A, Ojani, M, Petrovic, S, Slijepcevic, P, Stankovic, A, Surralles, J, Trujillo, JP, Vujic, D, Zivkovic, M   +11 more
core   +3 more sources

The Evolving Landscape of Immunotoxicity: Charting Mechanisms and Future Strategies for Immune Checkpoint Inhibitor Adverse Events

Med Research, EarlyView.
ABSTRACT The use of immune checkpoint inhibitors (ICIs) has significantly improved the efficacy of cancer therapy, but their associated immune‐related adverse events (irAEs) can severely compromise treatment safety. This review systematically summarizes the core mechanisms underlying irAEs, which include multi‐organ damage resulting from T‐cell ...
Anqi Lin, Keyin Zheng, Aimin Jiang, Xufeng Huang, Qi Wang, András Hajdu, Zhengrui Li, Jian Zhang, Peng Luo   +8 more
wiley   +1 more source

Altered expression of the TCR signaling related genes CD3 and FcεRIγ in patients with aplastic anemia [PDF]

, 2012
Background Aplastic anemia (AA) is characterized by pancytopenia and bone marrow hypoplasia, which results from immune-mediated hematopoiesis suppression.
AM Wegener, B Malissen, Bo Li, C Dufour, E Sloand, ED Zanders, EE Solomou, EJ Enyedy, EN Kersh, F Zhou, H Clevers, H Murata, JM Oliver, JP Maciejewski, K Amemiya, K Kaito, KJ Livak, L Ciszak, L Shiue, LA Pitcher, Lijian Yang, ME Call, ME Call, N Taylor, NC Zoumbos, NC Zoumbos, NS Young, NS Young, S Chen, S Koyasu, S Krishnan, SD Thompson, Shaohua Chen, Sichu Liu, Su Fang, T Kato, Xiuli Wu, Y Li, Yangqiu Li, Yuzhe Niu, Zhi Yu, ZM Sun   +41 more
core   +2 more sources

Pathogenesis of Acquired Aplastic Anemia and the Role of the Bone Marrow Microenvironment

Frontiers in Oncology, 2018
Aplastic anemia (AA) is characterized by bone marrow (BM) hypocellularity, resulting in peripheral cytopenias. An antigen-driven and likely auto-immune dysregulated T-cell homeostasis results in hematopoietic stem cell injury, which ultimately leads to ...
M. Medinger, B. Drexler, C. Lengerke, J. Passweg   +3 more
semanticscholar   +1 more source

A Possible Case of β‐Thalassemia From the Cemetery of Santa Maria Maggiore in Vercelli (Piedmont, Northern Italy,18th Century)

International Journal of Osteoarchaeology, EarlyView.
ABSTRACT In Italy's Piedmont region, the city of Vercelli has a history of malaria transmission due to favorable conditions for Anopheles mosquitoes, which may have influenced the genetic prevalence of thalassemia. This study investigates the skeletal remains of a nonadult individual from the Church of Santa Maria Maggiore in Vercelli, dating to the ...
R. Fusco, C. Tesi, A. Mazzucchi, A. Vanni, M. Licata   +4 more
wiley   +1 more source

Response of Paroxysmal Nocturnal Hemoglobinuria Clone with Aplastic Anemia to Rituximab

Case Reports in Hematology, 2012
Paroxysmal nocturnal hemoglobinuria is caused by expansion of a hematopoietic stem cell clone with an acquired somatic mutation in the PIG-A gene. This mutation aborts the synthesis and expression of the glycosylphosphatidylinositol anchor proteins CD55
Radha Raghupathy, Olga Derman
doaj   +1 more source

Spontaneously resolved severe retinopathy associated with aplastic anemia

Oman Journal of Ophthalmology, 2021
Aplastic anemia is a rare, usually autoimmune disorder of bone marrow stem cells leading to pancytopenia and hypoplastic marrow that presents with anemia, infection or bleeding which can be potentially sight and life-threatening.
Washoo Mal, Mohamed Al-Abri
doaj   +1 more source