Results 151 to 160 of about 5,264 (176)
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Antiviral Research, 2015
HIV-1 Vif protein is one of the most crucial accessory proteins for viral replication. It efficiently counteracts the important host restriction factor APOBEC3G (apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G, A3G) which is lethal to HIV-1 by causing G to A mutation of viral genome.
Shaoyang Zhang, Ting Pan, Hui Chen
exaly +3 more sources
HIV-1 Vif protein is one of the most crucial accessory proteins for viral replication. It efficiently counteracts the important host restriction factor APOBEC3G (apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G, A3G) which is lethal to HIV-1 by causing G to A mutation of viral genome.
Shaoyang Zhang, Ting Pan, Hui Chen
exaly +3 more sources
APOBEC3G and HIV-1: Strike and counterstrike
Current HIV/AIDS Reports, 2006APOBEC3G (A3G), a deoxycytidine deaminase, is a powerful host antiretroviral factor that can restrict HIV-1 infection. This restriction is counteracted by the HIV-1 virion infectivity factor (Vif) protein, whose activity culminates in depletion of A3G from infected cells.
Vanessa B, Soros, Warner C, Greene
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Apobec3G-Based Strategies to Defeat HIV Infection
Current HIV Research, 2016To suppress HIV infection, host cells have evolved numerous defenses that generally belong to the innate and adaptive immune responses. Over the last decade, extensive efforts have been focused on understanding HIV restriction factors and mechanisms of evasion.
Xiaozhuo, Ran, Zhujun, Ao, Xiaojian, Yao
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Functional domains of APOBEC3G required for antiviral activity
Journal of Cellular Biochemistry, 2004AbstractThe viral protein, Vif, is essential for the production of infectious progeny virions in natural target cells of human immunodeficiency virus type 1 (HIV‐1). Several recent reports indicate that Vif acts by antagonizing the activity of an endogenous human antiviral protein, APOBEC3G.
Jinliang, Li +2 more
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Inhibition of Hepatitis B Virus Replication by APOBEC3G
Science, 2004To replicate efficiently, viruses must overcome innate defense mechanisms. Human APOBEC3G is a cytidine deaminase that represents one such barrier, conferring broad intracellular antiretroviral protection.
Priscilla, Turelli +4 more
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APOBEC3G cytidine deaminase inhibits retrotransposition of endogenous retroviruses
Nature, 2005Endogenous retroviruses are multicopy retroelements accounting for nearly 10% of murine or human genomes. These retroelements spread into our ancestral genome millions of years ago and have acted as a driving force for genome evolution. Endogenous retroviruses may also be deleterious for their host, and have been implicated in cancers and autoimmune ...
Esnault, Cécile +7 more
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Unedited inhibition of HBV replication by APOBEC3G
Journal of Hepatology, 2004Inhibition of hepatitis B virus replication by APOBEC3G. Turelli P, Mangeat B, Jost S, Vianin S, Trono D. [Science 2004; 303: 1829]
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Hypermutation by intersegmental transfer of APOBEC3G cytidine deaminase
Nature Structural & Molecular Biology, 2008Deamination of cytidine residues in single-stranded DNA (ssDNA) is an important mechanism by which apolipoprotein B mRNA-editing, catalytic polypeptide-like (APOBEC) enzymes restrict endogenous and exogenous viruses. The dynamic process underlying APOBEC-induced hypermutation is not fully understood.
Roni, Nowarski +3 more
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